Results 91 to 100 of about 552,532 (299)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The homo/heterodimers of plasma membrane sugar transporters CsSWEET1a and CsSWEET17 mediate growth and cold stress tolerance

, 2020
Lina Yao, Changqing Ding, Xinyuan Hao, Jianming Zeng, Yajun Yang, Xinchao Wang, Lu Wang   +6 more
openalex   +1 more source

Regulation of Rat Dopamine Transporter mRNA and Protein by Chronic Cocaine Administration [PDF]

, 1999
Sharon R. Letchworth, Tom Sexton, Steven R. Childers, Kent E. Vrana, Roxanne A. Vaughan, Huw M. L. Davies, Linda J. Porrino   +6 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function [PDF]

, 2010
Malek El Muayed, Liana K. Billings, Meera R. Raja, Xiaomin Zhang, Paul Park, Marsha Newman, Dixon B. Kaufman, Thomas V. O’Halloran, William L. Lowe   +8 more
openalex   +1 more source

Detection of proton-dependent peptide uptake into liposomes by bacterial peptide transporter DtpB using pyranine assay

, 2023
Vadim Kotov, Katharina E. J. Jungnickel, Josi Steinke   +2 more
openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease

, 2023
D. J. Vidyadhara, Somayaji Mahalakshmi, Wade Nigel, Yucel Betul, Zhao Helen, N Shashaank, Ribaudo Joseph, Gupta Jyoti, T. Lam Tukiet, Sames Dalibor, E. Greene Lois, L. Sulzer David, S. Chandra Sreeganga   +12 more
openalex   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source