Results 21 to 30 of about 103,402 (150)

Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation

mSphere, 2019
Copper (Cu) is an essential trace element in all organisms, and Cu acquisition during periods of starvation is important for cell survival and proliferation.
Zhendong Cai, Wenlong Du, Lianhong Liu, Daodong Pan, Ling Lu   +4 more
doaj   +1 more source

Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters

Frontiers in Pharmacology, 2020
High-affinity monoamine transporters are targets for prescribed medications and stimulant drugs of abuse. Therefore, assessing monoamine transporter activity for candidate medications and newly-emerging drugs of abuse provides essential information for ...
Marija Ilic, Marija Ilic, Marija Ilic, Marion Holy, Kathrin Jaentsch, Matthias E. Liechti, Gert Lubec, Michael H. Baumann, Harald H. Sitte, Dino Luethi, Dino Luethi   +10 more
doaj   +1 more source

Transport Dynamics in a Glutamate Transporter Homologue [PDF]

Biophysical Journal, 2013
Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate binding sites become accessible to ...
Roger B. Altman, Nurunisa Akyuz, Olga Boudker, Scott C. Blanchard   +3 more
openaire   +4 more sources

Structural basis for mammalian nucleotide sugar transport

eLife, 2019
Nucleotide-sugar transporters (NSTs) are critical components of the cellular glycosylation machinery. They transport nucleotide-sugar conjugates into the Golgi lumen, where they are used for the glycosylation of proteins and lipids, and they then ...
Shivani Ahuja, Matthew R Whorton
doaj   +1 more source

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

eLife, 2023
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits.
Maurice A Petroccione, Lianna Y D'Brant, Nurat Affinnih, Patrick H Wehrle, Gabrielle C Todd, Shergil Zahid, Haley E Chesbro, Ian L Tschang, Annalisa Scimemi   +8 more
doaj   +1 more source

Response and Tolerance of Macleaya cordata to Excess Zinc Based on Transcriptome and Proteome Patterns

Plants, 2023
Macleaya cordata is a dominant plant of mine tailings and a zinc (Zn) accumulator with high Zn tolerance. In this study, M. cordata seedlings cultured in Hoagland solution were treated with 200 μmol·L−1 of Zn for 1 day or 7 days, and then, their leaves ...
Hongxiao Zhang, Linfeng Hu, Xinlong Du, Assar Ali Shah, Baseer Ahmad, Liming Yang, Zhiying Mu   +6 more
doaj   +1 more source

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Frontiers in Cell and Developmental Biology, 2023
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa, Koichiro Susa, Koichiro Susa, Kenichi Kobayashi, Kenichi Kobayashi, Pierre Galichon, Pierre Galichon, Takuya Matsumoto, Takuya Matsumoto, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Navin R. Gupta, Navin R. Gupta, Navin R. Gupta, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane   +30 more
doaj   +1 more source

Tracking multiple conformations occurring on angstrom-and-millisecond scales in single amino-acid-transporter molecules

eLife, 2023
Most membrane protein molecules undergo conformational changes as they transition from one functional state to another one. An understanding of the mechanism underlying these changes requires the ability to resolve individual conformational states, whose
Yufeng Zhou, John H Lewis, Zhe Lu
doaj   +1 more source

An international questionnaire highlights and supports the case for including girls in Creatine Transporter Deficiency research

Frontiers in Neuroscience
Over the last 15 years, significant progress has been made for Creatine Transporter Deficiency (CTD) patients, with increased awareness and visibility, better diagnosis, and improved care.
Carole Chehowah, Carole Chehowah, Audrey Mittelman, Vincent des Portes   +3 more
doaj   +1 more source

Synthesis of borate cross-linked rhamnogalacturonan II

Frontiers in Plant Science, 2015
In the present review, we describe current knowledge about synthesis of borate crosslinked rhamnogalacturonan II (RG-II) and it physiological roles. RG-II is a portion of pectic polysaccharide with high complexity, present in primary cell wall.
Hiroya eFunakawa, Kyoko eMiwa, Kyoko eMiwa   +2 more
doaj   +1 more source