Results 261 to 270 of about 153,753 (318)

The Right to Cultural Connection for Children in Out‐of‐Home Care: Does Australian Policy and Practice Adequately Support Cultural Identity for Culturally and Linguistically Diverse Children?

open access: yesAustralian Journal of Social Issues, EarlyView.
ABSTRACT Development of cultural identity is understood to be central to well‐being; however, it is not always prioritised for children in out‐of‐home care (OOHC). This paper examines current policy and practice designed to support the cultural identity and connection of non‐Indigenous culturally and linguistically diverse children (CALD) in OOHC, who ...
Rebekah Grace   +8 more
wiley   +1 more source

GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration

open access: yesAlzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION We examined how abnormal prefrontal neurophysiology and changes in gamma‐aminobutyric acid‐ergic (GABAergic) neurotransmission contribute to behavioral impairments in disorders associated with frontotemporal lobar degeneration (FTLD). METHODS We recorded magnetoencephalography during an adaptive visuomotor task from 11 people with
Laura E. Hughes   +11 more
wiley   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

open access: yesAnnals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa   +11 more
wiley   +1 more source

Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK‐FA Study

open access: yesAnnals of Neurology, EarlyView.
Objective We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. Methods TRACK‐FA is the largest prospective, longitudinal, multi‐modal neuroimaging study in Friedreich ataxia to date.
Nellie Georgiou‐Karistianis   +33 more
wiley   +1 more source

Continuous Flow Synthesis of Nitrofuran Pharmaceuticals Using Acetyl Nitrate

open access: yesAngewandte Chemie, EarlyView.
A robust, automated continuous flow system enables safe, high‐yield nitration of furfural to key nitrofuran intermediates using in situ acetyl nitrate generation. Demonstrated on representative essential World Health Organization (WHO) active pharmaceutical ingredients (API), this innovative open‐source platform ensures rapid synthesis, enhanced safety,
Hubert Hellwig   +8 more
wiley   +1 more source

Iridium‐Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands

open access: yesAngewandte Chemie, EarlyView.
The first kinetic resolution of allenylic alcohols by asymmetric allenylic substitution has been achieved, which was enabled by the design of a new chiral ligand that altered the energetic profiles of the previously established pathways. Both secondary and tertiary alcohols were suitable substrates.
Youshao Tu   +4 more
wiley   +1 more source

The Mechanism of Ruthenium‐Catalyzed Directed C─H Arylation of Arenes: The Key Role of Bis‐Cyclometalated Intermediates

open access: yesAngewandte Chemie, EarlyView.
The mechanism of Ru‐catalyzed N‐directed C─H ortho‐arylation with haloarenes is addressed through experimental stoichiometric, catalytic kinetic, and DFT studies. These reveal a key role for bis‐cyclometallated ruthenium species and show bromoarene activation proceeds via a concerted oxidative addition.
Pablo Domingo‐Legarda   +6 more
wiley   +1 more source

Transposable elements

Current Biology, 2022
Transposable elements are known by many names, including 'transposons', 'interspersed repeats', 'selfish genetic elements', 'jumping genes', and 'parasitic DNA', but here we will refer to them simply as transposable elements. Many biologists will have heard of transposable elements and their ability to transpose (change position) within the genome. But
Alexander, Hayward, Clément, Gilbert
openaire   +3 more sources

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