This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen +7 more
wiley +1 more source
The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell. [PDF]
Chen X +12 more
europepmc +1 more source
A Statistical Mechanics Model to Decode Tissue Crosstalk During Graft Formation
We introduce a statistical mechanics framework to decode the genomic crosstalk governing plant grafting. By integrating evolutionary game theory with transcriptomics, we reconstruct idopNetworks (informative, dynamic, omnidirectional, and personalized networks) that map scion–rootstock interactions.
Ang Dong +4 more
wiley +1 more source
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements. [PDF]
You JS, Pierce S, Liang G, Jones PA.
europepmc +1 more source
Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan +8 more
wiley +1 more source
Genomic characterization of repetitive DNA and transposable elements in Dyckia (Pitcairnioideae) species. [PDF]
Silva Rabelo-Araujo JVD +6 more
europepmc +1 more source
Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang +13 more
wiley +1 more source
Comprehensive Annotation of Olfactory and Gustatory Receptor Genes and Transposable Elements Revealed Their Evolutionary Dynamics in Aphids. [PDF]
Olvera-Vazquez SG +26 more
europepmc +1 more source

