Results 111 to 120 of about 111,214 (295)

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Giant transposons promote strain heterogeneity in a major fungal pathogen

mBio
Fungal infections are difficult to prevent and treat in large part due to strain heterogeneity, which confounds diagnostic predictability. Yet, the genetic mechanisms driving strain-to-strain variation remain poorly understood.
Emile Gluck-Thaler, Adrian Forsythe, Charles Puerner, Cecilia Gutierrez-Perez, Jason E. Stajich, Daniel Croll, Robert A. Cramer, Aaron A. Vogan   +7 more
doaj   +1 more source

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

An Enterobacter plasmid as a new genetic background for the transposon Tn1331

, 2011
Mohammad R Alavi1,2, Vlado Antonic2, Adrien Ravizee1, Peter J Weina3, Mina Izadjoo1,2, Alexander Stojadinovic21Division of Wound Biology and Translational Research, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC ...
Stojadinovic A, Ravizee A, Antonic V, Alavi MR, Izadjoo M, Weina PJ   +5 more
core  

Transposon mutagenesis in streptomycetes [PDF]

, 2014
Recent whole genome sequencing programs have revealed that the biosynthetic potential of Actinomycetales has been even underexplored with traditional approaches.
Bilyk, Bohdan
core  

In Vitro Characterization of Technological and Health‐Promoting Properties of Enterocin Producing Lactic Acid Bacteria From Camel Milk and Its Suitability as a Dairy Starter

Food Chemistry International, EarlyView.
Enterocin‐producing Enterococcus faecium RSCUDR7 from camel milk exhibited strong probiotic and antimicrobial properties, along with stability in skim milk. Its suitability as a safe and effective dairy starter highlights its potential for developing functional probiotic dairy products.
Rahul Singhal, Kamalesh Kumar Meena, Manvik Joshi, Lokesh Gupta, Sunil Meena   +4 more
wiley   +1 more source

Footprinting analysis of the transposon mutant library.

, 2012
(A) Schematic overview of the transposon footprinting strategy. PCR is performed using a gene specific primer and a primer corresponding to the transposon sequence.
Xinglin Zhang (146553), Fernanda L. Paganelli (155325), Damien Bierschenk (155334), Annemarie Kuipers (155345), Marc J. M. Bonten (109524), Willem van Schaik (146514), Rob J. L. Willems (146563)   +6 more
core   +1 more source

Structure-function analysis of the inverted terminal repeats of the Sleeping Beauty transposon

, 2002
Translocation of Sleeping Beauty (SB) transposon requires specific binding of SB transposase to inverted terminal repeats (ITRs) of about 230 bp at each end of the transposon, which is followed by a cut-and-paste transfer of the transposon into a target ...
Christopher D.Kaufman, Aron M.Geurts, Hackett, PB, Discovery Genom Inc, 614 McKinley Pl, Minneapolis, MN 55413 USA, Zongbin Cui, Geyi Liu, Perry B.Hackett   +5 more
core  

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Manure Composting as a Strategy to Mitigate Antibiotic Resistance Dissemination in Agricultural Systems

Land Degradation &Development, EarlyView.
ABSTRACT Livestock manure is a valuable agricultural resource but may introduce antibiotic residues and antibiotic resistance genes (ARGs) into the environment. This review critically evaluates the fate of antibiotics and ARGs during manure composting and identifies the principal factors controlling their attenuation.
Magdalena Urbaniak
wiley   +1 more source