Results 121 to 130 of about 111,214 (295)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

PCR screening of transposon-containing plasmid clones.

, 2013
(A) Cdh22 locus. The first transposon insertion was screened using the primer pair 1B5′/1B3′. The second transposon insertion was screened using the primer pair 2B5′/HSP430. (B) Drapc1 locus.
Hilkka Turakainen (374710), Harri Savilahti (17531), Jonna Saarimäki-Vire (364258), Juha Partanen (152574), Natalia Sinjushina (364257)   +4 more
core   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Amplification and detection of transposon insertion flanking sequences using fluorescent MuAFLP

, 2002
The amplification of transposon insertion-flanking sequences is the basis of a variety of techniques used for the detection and characterization of specific transposon insertion events.
Batley, J, Coghill, J., Holdsworth, M., Edwards, KJ, Edwards, D, Holdsworth, M. J., Holdsworth, M, Edwards, D., Coghill, J, Batley, J., Edwards, K. J.   +10 more
core  

The sleeping beauty transposon toolbox

, 2012
The mobility of class II transposable elements (DNA transposons) can be experimentally controlled by separating the two functional components of the transposon: the terminal inverted repeat sequences that flank a gene of interest to be mobilized and the ...
Ivics, Z., Ammar, I., Zsuzsanna Izsvák, Ismahen Ammar, Izsvak, Z., Zoltán Ivics   +5 more
core   +1 more source

Near‐T2T genome assembly of Erigeron sumatrensis provides insights into polyploid evolution and the herbicidal efficiency of HPPD inhibitors

New Plant Protection, EarlyView.
The near‐T2T genome assembly of Erigeron sumatrensis reveals an allohexaploid origin, evolution, and the interaction between the herbicidal target of the HPPD family and mesotrione. Abstract Species of Erigeron, members of the family Asteraceae, have invaded and adapted to agricultural fields and uncultivated habitats worldwide. Erigeron sumatrensis is
Yingying Wang, Jian Zhao, Jiao Zhang, Yaliang Shi, Xin Zhang, Feng Luo, Lianyang Bai, Meiliang Zhou, Zuren Li   +8 more
wiley   +1 more source

A Naturally Active Spy Transposon Discovered from the Insect Genome of Colletes gigas as a Promising Novel Gene Transfer Tool

Advanced Science
Novel active DNA transposons, such as Spy transposons from the PHIS superfamily, are identified through bioinformatics in this study. The native transposases cgSpy and cvSpy displayed transposition activities of approximately 85% and 35% compared to the ...
Mohamed Diaby, Han Wu, Bo Gao, Shasha Shi, Bingqing Wang, Saisai Wang, Yali Wang, Zherui Wu, Cai Chen, Xiaoyan Wang, Chengyi Song   +10 more
doaj   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

piggyBacTransposon

Microbiology Spectrum, 2015
ABSTRACTThepiggyBactransposon was originally isolated from the cabbage looper moth,Trichoplusia ni, in the 1980s. Despite its early discovery and dissimilarity to the other DNA transposon families, thepiggyBactransposon was not recognized as a member of a large transposon superfamily for a long time. Initially, thepiggyBactransposon was thought to be a
openaire   +2 more sources