Results 131 to 140 of about 61,872 (307)

SGLT2 inhibitors for the prevention and treatment of heart failure: A scientific statement of the HFA and the HFAI

ESC Heart Failure, EarlyView.
Abstract In the 2021 European Society of Cardiology (ESC) heart failure (HF) guidelines, sodium–glucose cotransporter 2 (SGLT2) inhibitors were recommended for the prevention of HF in patients with type 2 diabetes mellitus (T2DM) and for the treatment of HF with reduced ejection fraction (HFrEF).
Marco Metra, Daniela Tomasoni, Marianna Adamo, Offer Amir, Stefan D. Anker, Antoni Bayes‐Genis, Michael Boehm, Javed Butler, Ovidiu Chioncel, Gerasimos Filippatos, Finn Gustafsson, Ewa A. Jankowska, Juan Carlos Kaski, Brenda Moura, Mark C. Petrie, Piotr Ponikowski, Amina Rakisheva, Arsen Ristic, Francois Roubille, Gianluigi Savarese, Petar Seferovic, Peter van der Meer, Maurizio Volterrani, Andrew J. Coats, Vijay K. Chopra, Giuseppe Rosano   +25 more
wiley   +1 more source

Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India. [PDF]

, 2011
BackgroundIngested inorganic arsenic (InAs) is methylated to monomethylated (MMA) and dimethylated metabolites (DMA). Methylation may have an important role in arsenic toxicity, because the monomethylated trivalent metabolite [MMA(III)] is highly toxic ...
Basu, Arin, Chung, Joyce, Ghosh, Nilima, Guha Mazumder, DN, Kalman, David, Liaw, Jane, Mitra, Soma, Smith, Allan H, Steinmaus, Craig, von Ehrenstein, Ondine S   +9 more
core   +2 more sources

A new staging system for hereditary transthyretin amyloidosis in the era of specific amyloidosis therapies

ESC Heart Failure, EarlyView.
The aim of our study was to develop a more accurate staging system for hereditary ATTR patients currently receiving specific treatment. A staging system was created using as criteria: GLS ≤ −11%, NT‐proBNP ≤ 2,000 ng/L, and eGFR ≤ 65 mL/min. We managed to accurately stratify patients into three disease stages, significantly different in terms of ...
Gabriela Neculae, Amira Zaroui, Robert Adam, Mounira Kharoubi, Benoit Funalot, Daniel Coriu, Ruxandra Jurcut, Thibaud Damy   +7 more
wiley   +1 more source

The two shapes of the Tau protein

eLife, 2018
Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
Jeffery W Kelly
doaj   +1 more source

Misdiagnosis of hereditary amyloidosis as AL (Primary) amyloidosis [PDF]

, 2002
Background: Hereditary, autosomal dominant amyloidosis, caused by mutations in the genes encoding transthyretin, fibrinogen A -chain, lysozyme, or apolipoprotein A-I, is thought to be extremely rare and is not routinely included in the differential ...
Booth, D.R., Booth, S.E., Bybee, A., Gilbertson, J.A., Gillmore, J.D., Hawkins, P.N., Lachmann, H.J., Pepys, M.B.   +7 more
core  

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay [PDF]

, 2015
BACKGROUND: Currently there are no effective treatments for many neurodegenerative diseases. Reliable biomarkers for identifying and stratifying these diseases will be important in the development of future novel therapies.
Bahtia, K, Bliss, E, Carecchio, M, Fenoglio, C, Fox, NC, Galimberti, D, Hardy, J, Heales, S, Heslegrave, A, Heywood, WE, Magdalinou, NK, Mills, K, Paterson, RW, Reid, E, Scarpini, E, Schott, JM, Sebire, NJ, Sirka, E, Zetterburg, H   +18 more
core   +1 more source

Diagnostic accuracy of amyloid scintigraphy for the histopathological diagnosis of cardiac transthyretin amyloidosis – a retrospective Austrian multicenter study [PDF]

, 2022
Nicolas Verheyen, Maria Ungericht, Lisa Paar, Kathrin Danninger, Stephanie Schneiderbauer‐Porod, F Duca, V Hoeller, Klemens Ablasser, Daniel Kiblboeck, Matthias Frick, D Bonderman, Josef Dierneder, Christian Ebner, Thomas Weber, Gerhard Poelzl   +14 more
openalex   +1 more source

A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Transthyretin Amyloidosis

Neurological Therapeutics, 2020
Hereditary variant transthyretin amyloidosis (ATTRv) is a rare genetic defect that affects about 5000–10,000 people worldwide, causing amyloidosis secondary to misfolding of mutant transthyretin (TTR) protein fibrils.
Ivan Urits, Daniel Swanson, Michael C Swett, Anjana Patel, Kevin Berardino, Ariunzaya Amgalan, A. Berger, Hisham Kassem, A. Kaye, Omar Viswanath   +9 more
semanticscholar   +1 more source

Nuclear imaging and echocardiographic findings in hypertrophic cardiomyopathy with and without ATTR‐CM

ESC Heart Failure, EarlyView.
Abstract Aims Patients with transthyretin amyloid cardiomyopathy (ATTR‐CM) often experience delayed diagnosis, which may detrimentally impact clinical outcomes. This study aimed to assess the frequency of use of planar scintigraphy with and without single‐photon emission computed tomography (SPECT) in patients with hypertrophic cardiomyopathy (HCM ...
Pablo Garcia‐Pavia, Francisco Javier Haro del Moral, Francesco Cappelli, Nicolas Piriou, Roberto Barriales‐Villa, Carmen Munteanu, Catherine Bahus, Denis Keohane, Pablo Mallaina, Emmanuel Itti, Thibaud Damy, Perry Elliott   +11 more
wiley   +1 more source

Piscine (Sparus aurata) transthyretin cDNA cloning and characterization [PDF]

, 1997
Transthyretin (TTR) is one of the three plasma proteins that participate in the transport of thyroid hormones, thyroxine (T4) and triiodothyronine (T3); it is also involved in the carriage of retinol through the mediation of retinol-binding protein.1 ...
Achen M. G., Duan W., Duan W., Richardson S.   +3 more
core   +1 more source