Results 131 to 140 of about 45,139 (271)

Genetic Structures and Conditions of their Expression, which Allow Receiving Native Recombinant Proteins with High Output [PDF]

International Journal of Biomedicine, 2012
We investigated the possibility of obtaining native recombinant amyloidogenic proteins by creating genetic constructs encoding fusion proteins of target proteins with Super Folder Green Fluorescent Protein (sfGFP).
Michael M. Shavlovsky, PhD, ScD¹, Irina V. Morozova¹, Dmitry S. Polyakov, PhD¹, Tatyana D. Aleynikova, PhD¹, Anna M. Kern², Natalya A. Grudinina, PhD¹, Kirill V. Solovyov, PhD¹   +6 more
doaj  

Biochemical marker in familial amyloidotic polyneuropathy, Portuguese type. Family studies on the transthyretin (prealbumin)-methionine-30 variant. [PDF]

, 1985
Maria João Saraiva, Paulo Costa, D S Goodman   +2 more
openalex   +1 more source

A functional role for spontaneously occurring natural anti‐transthyretin antibodies from patients with transthyretin cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Ortal Tuvali, Michael Fassler, Sorel Goland, Clara Benaim, Sara Shimoni, Jacob George   +5 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Tegsedi-Induced Warm Antibody Autoimmune Hemolytic Anemia

Annals of Internal Medicine: Clinical Cases
Autoimmune hemolytic anemia is a hemolytic disorder in which antibodies attack erythrocytes, causing their destruction. Many medications have been linked to autoimmune hemolytic anemia, such as antibiotics, chemotherapy agents, and nonsteroidal anti ...
Mariela Di Vanna, Nawal Aamir, Cristina Rodriguez Andujar, Adam Kaplan   +3 more
doaj   +1 more source

Simplified method for screening populations at risk for transthyretin Met30-associated familial amyloidotic polyneuropathy. [PDF]

, 1989
Maria João Saraiva, Isabel L. Alves, Paulo Costa   +2 more
openalex   +1 more source

Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences

Aging Cell, EarlyView.
The connections between epigenetic age acceleration (EAA) and the multi‐ome, as well as the extent to which these connections are driven by genetic and environmental factors, remain underexplored. We identified blood proteins, metabolites, and exposures associated with EAA in young adults and, using twin study designs, show that these associations are ...
Gabin Drouard, Sannimari Suhonen, Aino Heikkinen, Zhiyang Wang, Jaakko Kaprio, Miina Ollikainen   +5 more
wiley   +1 more source

Cloning and nucleotide sequencing of transthyretin (prealbumln) cDNA from rat choroid plexus and liver [PDF]

, 1989
Wei Duan, Timothy Cole, Gerhard Scheriber   +2 more
openalex   +1 more source

Fish and amphibians as test organisms for evaluation of effects caused by chemicals [PDF]

, 2007
A large number of chemicals can contaminate aquatic environments and therefore be exposed to fish and amphibians during their sensitive stages of development.
Carlsson, Gunnar
core  

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells

, 2017
Familial amyloid polyneuropathy (FAP) is caused by mutations of the transthyretin (TTR) gene, predominantly expressed in the liver. Two compounds that knockdown TTR, comprising a small interfering RNA (siRNA; ALN-TTR-02) and an antisense oligonucleotide (
Ackermann, E.J. (Elisabeth), Avsar, Y. (Yesim), Chandhok, G. (Gursimran), Fleischhauer, L. (Lutz), Gollob, J. (Jared), Guo, S. (Shuling), Guttmann, S. (Sarah), Monia, B.P. (Brett), Niemietz, C. (Christoph), Sauer, V.D. (Vanessa), Schmidt, H. (Hartmut), Stella, J. (Jaqueline), Zibert, A. (Andree)   +12 more
core   +1 more source