Results 31 to 40 of about 60,909 (346)
Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy
JAMA cardiology, 2023 Key Points Question Does tafamidis, 80 mg, affect cardiac function in patients with transthyretin amyloid cardiomyopathy? Findings In this post hoc analysis of the randomized Tafamidis in Transthyretin Cardiomyopathy Clinical Trial including 441 patients,
Sanjiv J. Shah +10 more
semanticscholar +1 more source
Transthyretin Amyloidosis and the Kidney [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary The amyloidoses are protein-misfolding disorders associated with progressive organ dysfunction. Immunoglobulin light chain is the most common, amyloid A the longest recognized, and transthyretin-associated amyloidosis (ATTR) the most frequent inherited systemic form.
Luísa Lobato, Ana Rocha
openaire +2 more sources
The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig [PDF]
, 2005 Peer reviewedPublisher ...
Andresen, L O +5 more
core +3 more sources
Decreased transthyretin predicts a poor prognosis in primary myelodysplastic syndrome
Frontiers in Nutrition, 2023 BackgroundThis study aims to investigate the prognostic significance of transthyretin in newly diagnosed myelodysplastic syndromes (MDS).MethodsThe clinical, laboratory, and follow-up data of 280 newly diagnosed patients with MDS were collected.
Ying Chen +29 more
doaj +1 more source
European Journal of Neurology, 2023 Hereditary transthyretin amyloidosis (ATTRv) is a life‐threatening disease caused by mutations in the gene encoding transthyretin (TTR). The recent therapeutic advances have underlined the importance of easily accessible, objective biomarkers of both ...
A. Romano +15 more
semanticscholar +1 more source
Cardiology Journal, 2022 BACKGROUND: Transthyretin amyloidosis (ATTR) is a rare, life-threatening systemic disorder. We present first findings on the cardiac hereditary ATTR in Poland.
Monika Gawor +11 more
doaj +1 more source
The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa [PDF]
, 2016 Transthyretin (TTR) pV142I (rs76992529-A) is one of the 113 variants in the human TTR gene associated with systemic amyloidosis. It results from a G to A transition at a CG dinucleotide in the codon for amino acid 122 of the mature protein (TTR V122I ...
Alexander, Alice A +10 more
core +1 more source
Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis [PDF]
The FEBS Journal, 2009 Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins.
openaire +3 more sources
Hereditary transthyretin amyloidosis
Нервно-мышечные болезни, 2020 Hereditary transthyretin amyloidosis is described in this review, including the TTR gene structure and mutation spectrum, the transthyretin protein structure and functions, the main clinical manifestations of transthyretin amyloidosis.
T. A. Adyan, A. V. Polyakov
doaj +1 more source
Uncovering the Mechanism of Aggregation of Human Transthyretin. [PDF]
, 2015 The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis.
Cascio, Duilio +9 more
core +2 more sources