Results 41 to 50 of about 61,872 (307)

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Evaluation of Albumin, Transferrin and Transthyretin in Inflammatory Bowel Disease Patients as Disease Activity and Nutritional Status Biomarkers

Nutrients, 2023
Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), is often accompanied by malnutrition that manifests itself as nutrient deficiencies and body mass loss or deficit. The purpose of this study is to evaluate
M. Godala, E. Gaszyńska, K. Walczak, E. Małecka-Wojciesko   +3 more
semanticscholar   +1 more source

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine, 2015
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti   +17 more
doaj   +1 more source

Specific Therapy for Transthyretin Cardiac Amyloidosis: A Systematic Literature Review and Evidence‐Based Recommendations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The emergence of specific therapies for transthyretin cardiac amyloidosis (CA) warrants the need for a systematic review of the literature.
Nuno Marques, Olga Azevedo, Ana Rita Almeida, Dina Bento, Inês Cruz, Emanuel Correia, Carolina Lourenço, Luís Rocha Lopes   +7 more
doaj   +1 more source

Klotho controls the brain-immune system interface in the choroid plexus. [PDF]

, 2018
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn, Kim, Daniel, Larsson, Tobias E, Mucke, Lennart, Stein, Liana R, Yu, Gui-Qiu, Zhan, Lihong, Zhu, Lei   +7 more
core   +1 more source

The Extracellular Protein, Transthyretin Is an Oxidative Stress Biomarker

Frontiers in Physiology, 2019
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol binding protein complex to the various parts of the body.
Meesha Sharma, Sheeza Khan, Safikur Rahman, Laishram Rajendrakumar Singh   +3 more
doaj   +1 more source

Hereditary transthyretin-related amyloidosis is frequent in polyneuropathy and cardiomyopathy of no obvious aetiology

Annals of Medicine, 2021
Background Hereditary Transthyretin-Related Amyloidosis, a clinically heterogeneous autosomal dominant disease caused by pathogenic variants in the TTR gene, is characterized by the deposition of insoluble misfolded protein fibrils.
Volha Skrahina, Ulrike Grittner, Christian Beetz, Thomas Skripuletz, Martin Juenemann, Heidrun H. Krämer, Katrin Hahn, Andreas Rieth, Volker Schaechinger, Monica Patten, Christian Tanislav, Stephan Achenbach, Birgit Assmus, Fabian Knebel, Stefan Gingele, Aliaksandr Skrahin, Jörg Hartkamp, Toni M. Förster, Sabine Roesner, Catarina Pereira, Arndt Rolfs   +20 more
doaj   +1 more source

Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]

, 2012
Peer reviewedPublisher ...
Agouni, Abdelali, Delibegovic, Mirela, Hoggard, Nigel, Mody, Nimesh   +3 more
core   +3 more sources

Proteomic analysis of plasma proteins of high-flux haemodialysis and on-line haemodiafiltration patients reveals differences in transthyretin levels related with anaemia

Scientific Reports, 2020
A large proportion of end-stage renal disease (ESRD) patients under long-term haemodialysis, have persistent anaemia and require high doses of recombinant human erythropoietin (rhEPO).
Emma Martínez-Alonso, Paula Alcázar, Emilio Camafeita, Milagros Fernández-Lucas, Gloria Ruíz-Roso, Alberto Alcázar   +5 more
doaj   +1 more source

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources