Results 41 to 50 of about 45,139 (271)

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Differences in transcription between free-living and CO_2-activated third-stage larvae of Haemonchus contortus [PDF]

, 2010
Background: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide. The infective third-stage larva (L3) of this gastric nematode is enclosed in a cuticle (sheath) and, once
Aleman-Meza, Boanerges, Campbell, Bronwyn E., Cantacessi, Cinzia, Gasser, Robin B., Hall, Ross S., Jex, Aaron R., Loukas, Alex, Presidente, Paul J. A., Sternberg, Paul W., Young, Neil D., Zawadzki, Jodi L., Zhong, Weiwei   +11 more
core   +6 more sources

Transthyretin Stabilizers and Seeding Inhibitors as Therapies for Amyloid Transthyretin Cardiomyopathy

Pharmaceutics, 2023
Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a progressive and increasingly recognized cause of heart failure which is associated with high mortality and morbidity. ATTR-CM is characterized by the misfolding of TTR monomers and their deposition within the myocardium as amyloid fibrils.
Paolo Morfino, Alberto Aimo, Giuseppe Vergaro, Chiara Sanguinetti, Vincenzo Castiglione, Maria Franzini, Marco Alfonso Perrone, Michele Emdin   +7 more
openaire   +7 more sources

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources

Klotho controls the brain-immune system interface in the choroid plexus. [PDF]

, 2018
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn, Kim, Daniel, Larsson, Tobias E, Mucke, Lennart, Stein, Liana R, Yu, Gui-Qiu, Zhan, Lihong, Zhu, Lei   +7 more
core   +1 more source

Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC

Fluids and Barriers of the CNS, 2018
Background Choroid plexus epithelial cells express high levels of transthyretin, produce cerebrospinal fluid and many of its proteins, and make up the blood-cerebrospinal fluid barrier. Choroid plexus epithelial cells are vital to brain health and may be
Brett A. Johnson, Margaret Coutts, Hillary M. Vo, Xinya Hao, Nida Fatima, Maria J. Rivera, Robert J. Sims, Michael J. Neel, Young-Jin Kang, Edwin S. Monuki   +9 more
doaj   +1 more source

Cerebellar and Cerebral Amyloid Visualized by [18F]flutemetamol PET in Long-Term Hereditary V30M (p.V50M) Transthyretin Amyloidosis Survivors

Frontiers in Neurology, 2022
IntroductionHereditary transthyretin (ATTRv) amyloidosis caused by the V30M (p. V50M) mutation is a fatal, neuropathic systemic amyloidosis. Liver transplantation has prolonged the survival of patients and central nervous system (CNS) complications ...
Erica Irene Uneus, Christer Wilhelmsson, David Bäckström, Intissar Anan, Intissar Anan, Jonas Wixner, Björn Pilebro, Katrine Riklund, Mattias Ögren, Margareta Ögreen, Jan Axelsson, Ole B. Suhr, Torbjörn Sundström   +12 more
doaj   +1 more source

Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune, and Endothelial Cells [PDF]

, 2019
Early detection of lung cancer offers an important opportunity to decrease mortality while it is still treatable and curable. Thirteen secretory proteins that are Stat3 downstream gene products were identified as a panel of biomarkers for lung cancer ...
Ding, Xinchun, Du, Hong, Lee, Chih-Chun, Perkins, Susan, Wu, Lingyan, Yan, Cong, Zhao, Ting   +6 more
core   +1 more source

Familial amyloid polyneuropathy TTR Cys 114 in monozygotic twin brothers (clinical case)

Нервно-мышечные болезни, 2017
Transthyretin amyloidosis (ATTR) is a hereditary autosomal dominant disease. Its symptoms depend on polymorphisms of the transthyretin gene and include disorders of the peripheral nervous system and internal organs.
M. O. Kovalchuk, I. A. Strokov
doaj   +1 more source

Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide [PDF]

, 2011
Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register $\beta$-sheets, the primary structural component of amyloid fibrils, is a first step towards describing \emph{in vivo} protein aggregation and ...
Allen M. P., Asakura S., Auer S., Batra J., Behe M., Bernard R. Brooks, Brooks B. R., Chan J. C. C., Cheung M. S., Chiti F., Colvin V. L., Colvin V. L., Cotter M. A., Cunha S., D. Thirumalai, del Álamao M., Dhar A., Dima R. I., Edward P. O’Brien, Elcock A. H., Fleer G. J., Flory P. J., Hall D., Hofrichter J., Jaroniec C. P., Jaroniec C. P., John. E. Straub, Lazaridis T., Lindner R. A., Linse S., Magno A., McGuffee S. R., Nelson R., Nelson R., Nguyen P. H., Petty S. A., Pierotti R. A., Rohrig U. F., Ross P. D., Sacchettini J. C., Schreiber G., Shaw M. R., Stagg L., Straub J. E., Tarus B., Tellam R. L., Tycko R., Walter H., Wu C., Zhou H. X., Zimmerman S. B.   +50 more
core   +1 more source