Results 61 to 70 of about 61,872 (307)

Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC

Fluids and Barriers of the CNS, 2018
Background Choroid plexus epithelial cells express high levels of transthyretin, produce cerebrospinal fluid and many of its proteins, and make up the blood-cerebrospinal fluid barrier. Choroid plexus epithelial cells are vital to brain health and may be
Brett A. Johnson, Margaret Coutts, Hillary M. Vo, Xinya Hao, Nida Fatima, Maria J. Rivera, Robert J. Sims, Michael J. Neel, Young-Jin Kang, Edwin S. Monuki   +9 more
doaj   +1 more source

Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy [PDF]

, 2009
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated ...
De Letter, Els, Delanghe, Joris, Delanghe, S, Derycke, Lara, Geers, I, Van Aken, Elisabeth, van Enschot, T, Veckeneer, M   +7 more
core   +3 more sources

Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy.

New England Journal of Medicine
BACKGROUND Transthyretin amyloid cardiomyopathy is characterized by the deposition of misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR stabilizer that acts to inhibit dissociation of tetrameric TTR and leads to more
J. Gillmore, D. Judge, F. Cappelli, M. Fontana, Pablo Garcia-Pavia, S. Gibbs, M. Grogan, Mazen Hanna, James Hoffman, Ahmad Masri, M. Maurer, Jose Nativi-Nicolau, L. Obici, S. Poulsen, Frank W. Rockhold, Keyur B. Shah, Prem Soman, Jyotsna Garg, Karen Chiswell, Haolin Xu, Xiaofan Cao, Ted Lystig, Uma Sinha, Jonathan C. Fox   +23 more
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Familial amyloid polyneuropathy TTR Cys 114 in monozygotic twin brothers (clinical case)

Нервно-мышечные болезни, 2017
Transthyretin amyloidosis (ATTR) is a hereditary autosomal dominant disease. Its symptoms depend on polymorphisms of the transthyretin gene and include disorders of the peripheral nervous system and internal organs.
M. O. Kovalchuk, I. A. Strokov
doaj   +1 more source

Structure of human transthyretin complexed with bromophenols: a new mode of binding [PDF]

, 2000
The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography ...
Bergman, A, Brouwer, A, Cook, Atlanta, Ghosh, M, Johnson, L N, Meerts, I A   +5 more
core   +2 more sources

Progression of echocardiographic parameters and prognosis in transthyretin cardiac amyloidosis

European Journal of Heart Failure, 2022
Transthyretin amyloid cardiomyopathy (ATTR‐CM) is an increasingly diagnosed disease. Echocardiography is widely utilized, but studies to confirm the value of echocardiography for tracking changes over time are not available.
L. Chacko, N. Karia, L. Venneri, F. Bandera, Beatrice Dal Passo, Lodovico Buonamici, J. Lazari, A. Ioannou, A. Porcari, R. Patel, Y. Razvi, James T Brown, D. Knight, A. Martinez-Naharro, C. Whelan, C. Quarta, C. Manisty, J. Moon, D. Rowczenio, J. Gilbertson, H. Lachmann, A. Wechelakar, A. Petrie, W. Moody, R. Steeds, L. Potena, Mattia Riefolo, O. Leone, C. Rapezzi, P. Hawkins, J. Gillmore, M. Fontana   +31 more
semanticscholar   +1 more source

Stroke volume and myocardial contraction fraction in transthyretin amyloidosis cardiomyopathy: A systematic review

Frontiers in Cardiovascular Medicine, 2023
BackgroundCardiac amyloidosis (CA) is primarily a restrictive cardiomyopathy in which the impairment of diastolic function is dominant. Despite this, the left ventricular ejection fraction (LVEF) may be depressed in the late stage of the disease, but it ...
Serenelli Matteo, Cantone Anna, Sanguettoli Federico, Maio Daniele, Fabbri Gioele, Dal Passo Beatrice, Pavasini Rita, Tonet Elisabetta, Passarini Giulia, Rapezzi Claudio, Campo Gianluca   +10 more
doaj   +1 more source

Metabolic interactions between vitamin A and conjugated linoleic acid [PDF]

, 2014
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner.
BANNI, SEBASTIANO, Belury, MA, CARTA, GIANFRANCA, Cordeddu, L, Giordano, E, MURRU, MARIA ELISABETTA, Ortiz, B, Quadro, L   +7 more
core   +2 more sources

Expert consensus on the monitoring of transthyretin amyloid cardiomyopathy

European Journal of Heart Failure, 2021
Transthyretin amyloid cardiomyopathy (ATTR‐CM) is a life‐threatening condition with a heterogeneous clinical presentation. The recent availability of treatment for ATTR‐CM has stimulated increased awareness of the disease and patient identification ...
P. García-Pavía, Frank Bengel, Dulce Brito, Thibaud Damy, F. Duca, S. Dorbala, J. Nativi-Nicolau, L. Obici, Claudio Rapezzi, Yoshiki Sekijima, Perry M. Elliott   +10 more
semanticscholar   +1 more source