Results 61 to 70 of about 29,341 (237)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Navigating the Lead Paradox: Successful Co‐Implantation of Cardiac Contractility Modulation Device and a Micra Leadless Pacemaker

Journal of Cardiovascular Electrophysiology, EarlyView.
This central illustration visually summarizes the first co‐implantation of a Cardiac Contractility Modulation (CCM) system and a Micra leadless pacemaker in a 78‐year‐old male with wild‐type transthyretin cardiac amyloidosis and NYHA Class III heart failure.
Gabriele Pavani, Paolo Garrone, Gianpaolo Varalda, Antonino Previti, Matteo Bianco, Alessandra Chinaglia   +5 more
wiley   +1 more source

Low transthyretin concentration linked to adverse prognosis in elderly inpatients

BMC Geriatrics
Background To investigate the association between low transthyretin (prealbumin) concentration and mortality or readmission for all causes in elderly inpatients.
Ting Wang, Zhi-kai Yang, Yu-hao Wan, Ke Chai, Ying-ying Li, Yao Luo, Min Zeng, Ning Sun, Song Zou, Hua Wang   +9 more
doaj   +1 more source

Screening and Diagnosis of Malnutrition in Individuals With Obesity: A Scoping Review of Current Methods

Obesity Reviews, EarlyView.
ABSTRACT Rationale The global rise in obesity presents a major public health challenge, commonly associated with an increased risk of noncommunicable diseases. Paradoxically, individuals with obesity, particularly older adults and those with comorbidities, are also at risk of malnutrition.
Natasha Nalucha Mwala, Jos W. Borkent, Carliene van Dronkelaar, Jeanne J. F. A. in 't Hulst, Barbara S. van der Meij, Maarten R. Soeters, Marian A. E. de van der Schueren   +6 more
wiley   +1 more source

EE526 Cost-Effectiveness Analysis of Transthyretin-Associated Amyloid Cardiomyopathy from the Brazilian Public Healthcare System Perspective [PDF]

, 2023
Maria João Sebastião, Pedro Antônio Muniz Ferreira, T. Senna, R.F. Alexandre, Pedro Almeida   +4 more
openalex   +1 more source

In vitro muscle contraction: A technical review on electrical pulse stimulation in C2C12 cells

Experimental Physiology, EarlyView.
Abstract Electrical pulse stimulation (EPS) of skeletal muscle cells is increasingly used to model exercise In vitro. The murine C2C12 myotube system has become a common platform for such studies, yet wide variability in EPS protocols hampers reproducibility and cross‐study comparisons.
Mark R. C. van de Meene, Anita M. van den Hoek, Roeland Hanemaaijer, Lars Verschuren, Jelle C. B. C. de Jong   +4 more
wiley   +1 more source

Transthyretin is a promising prognostic marker of non-developing pregnancy in hypothyroidism

Фундаментальная и клиническая медицина
Non-developing pregnancy is one of the most important problems in the practice of an obstetrician-gynecologist. Transthyretin is a transplacental transport protein of T3, T4 and is expressed in cyto- and syncytiotrophoblast cells.
A. A. Orazmuradov, J. D. Suleymanova, E. A. Kuzmina, E. V. Mukovnikova, Kh. Haddad, A. N. Akhmatova   +5 more
doaj   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, Andrew F. James, Svetlana Mastitskaya   +2 more
wiley   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Hereditary Transthyretin Amyloidosis Polyneuropathy

Journal of the Peripheral Nervous System, Volume 31, Issue 1, March 2026.
ABSTRACT Background and Aims In individuals with hereditary transthyretin amyloidosis (ATTRv) polyneuropathy, monitoring of disease progression and treatment response is crucial. The objective is to determine if serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) are reliable biomarkers of ATTRv polyneuropathy ...
Valentin Loser, Pascal Benkert, Alex Vicino, Nicolas Ghika, Pansy Lim Dubois Ferrière, Chantal Daigneault, Thierry Kuntzer, Aleksandra Maleska Maceski, Jens Kuhle, Marie Théaudin   +9 more
wiley   +1 more source