Results 71 to 80 of about 21,795 (202)
The two shapes of the Tau protein
eLife, 2018 Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
Jeffery W Kelly
doaj +1 more source
ApoJ regulates endothelial lipase activity and stability
Protein Science, Volume 35, Issue 4, April 2026.Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste +5 more
wiley +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Protein Science, Volume 35, Issue 4, April 2026.Abstract The deposition of cytotoxic human islet amyloid polypeptide (IAPP) aggregates is a hallmark feature of Type 2 Diabetes. However, the structural evolution and cytotoxicity of IAPP aggregate species remain poorly understood. This study combines kinetics, biophysical and cell assays to resolve the morphological dynamics of IAPP aggregation. Using
Daniel Warren +2 more
wiley +1 more source
Cryptogenic ischemic stroke in cardiac transthyretin amyloidosis and sinus rhythm: a case report
Frontiers in Cardiovascular MedicineCardiac amyloidosis is a group of diseases characterized by the deposition of amyloid fibers in cardiac tissue. Two forms are mainly reported: light chain (AL) and transthyretin (ATTR) amyloidosis.
Angela Napolitano +5 more
doaj +1 more source
Systemic transthyretin amyloidosis: carpal tunnel syndrome in a Portuguese population (CarPoS) [PDF]
Exploration of CardiologyCarpal tunnel syndrome (CTS) is the most common type of entrapment neuropathy and affects approximately 1% to 5% of the general population, mostly patients older than 50 years.
Sofia Pimenta +11 more
doaj +1 more source
Protein Science, Volume 35, Issue 4, April 2026.Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova +2 more
wiley +1 more source
Arquivos de Neuro-PsiquiatriaBackground Hereditary transthyretin amyloidosis (ATTRv) is an inherited, progressive, and fatal disease still largely underdiagnosed. Mutations in the transthyretin (TTR) gene cause the TTR protein to destabilize, misfold, aggregate, and ...
Moises Dias +9 more
doaj +1 more source
Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design
Advanced Science, Volume 13, Issue 14, 9 March 2026.Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao +4 more
wiley +1 more source
Palinacousis in amyloidosis: exploring the hallucinatory phenomenon in brain pathology—a case report
Journal of Medical Case ReportsBackground Hereditary transthyretin amyloidosis, caused by transthyretin gene mutations, progresses with systemic impact and often presents peripheral neuropathy.
João Martins-Correia, Luísa Sousa
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