Results 71 to 80 of about 60,909 (346)

Neuropathic pain experience in symptomatic and presymptomatic subjects carrying a transthyretin gene mutation

Frontiers in Neurology, 2023
IntroductionPain is a common symptom of hereditary transthyretin amyloidosis (ATTRv), however, its occurrence in late-onset ATTRv has not been investigated thoroughly. Our aim was to describe the pain experience and its impact on quality of life (QoL) in
Stefano Tozza, Marco Luigetti, Marco Luigetti, Giovanni Antonini, Anna Mazzeo, Daniele Severi, Andrea Di Paolantonio, Andrea Di Paolantonio, Luca Leonardi, Massimo Russo, Angela Romano, Angela Romano, Francesca Forcina, Luca Gentile, Maria Nolano, Maria Nolano, Consalvo Mattia, Consalvo Mattia, Fiore Manganelli   +18 more
doaj   +1 more source

Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy [PDF]

, 2009
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated ...
De Letter, Els, Delanghe, Joris, Delanghe, S, Derycke, Lara, Geers, I, Van Aken, Elisabeth, van Enschot, T, Veckeneer, M   +7 more
core   +3 more sources

Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy.

New England Journal of Medicine
BACKGROUND Transthyretin amyloid cardiomyopathy is characterized by the deposition of misfolded monomeric transthyretin (TTR) in the heart. Acoramidis is a high-affinity TTR stabilizer that acts to inhibit dissociation of tetrameric TTR and leads to more
J. Gillmore, D. Judge, F. Cappelli, M. Fontana, Pablo Garcia-Pavia, S. Gibbs, M. Grogan, Mazen Hanna, James Hoffman, Ahmad Masri, M. S. Maurer, Jose Nativi-Nicolau, L. Obici, S. Poulsen, Frank Rockhold, Keyur B Shah, Prem Soman, Jyotsna Garg, Karen Chiswell, Haolin Xu, Xiaofan Cao, Ted Lystig, Uma Sinha, Jonathan C. Fox   +23 more
semanticscholar   +1 more source

Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure With Preserved Ejection Fraction.

JAMA cardiology, 2021
Importance Heart failure (HF) with preserved ejection fraction (HFpEF) is common, is frequently associated with ventricular wall thickening, and has no effective therapy.
O. AbouEzzeddine, Daniel R Davies, C. Scott, Ahmed U. Fayyaz, J. Askew, P. McKie, P. Noseworthy, G. Johnson, S. Dunlay, B. Borlaug, P. Chareonthaitawee, V. Roger, A. Dispenzieri, M. Grogan, M. Redfield   +14 more
semanticscholar   +1 more source

Bifunctional crosslinking ligands for transthyretin [PDF]

Open Biology, 2015
Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing acquired and hereditary systemic TTR amyloidosis, a debilitating and usually fatal disease.
Carol V. Robinson, Steve P. Wood, Stéphanie Deroo, Victoria A. Steadman, Palma Mangione, Palma Mangione, Vittorio Bellotti, Vittorio Bellotti, Robert J. Broadbridge, Mark B. Pepys, Graham W. Taylor, Joanne R. Thurston, Simon Kolstoe, Antonio K. Vong, Glenys A. Tennent, Christopher J. Swain, Martin D. Smith, Stephan Ellmerich   +17 more
openaire   +8 more sources

Mechanisms of Transthyretin Inhibition of IAPP Amyloid Formation

Biomolecules, 2021
Amyloid-formation by the islet amyloid polypeptide (IAPP), produced by the β-cells in the human pancreas, has been associated with the development of type II diabetes mellitus (T2DM).
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson   +7 more
doaj   +1 more source

Clinical and genetic profile of patients enrolled in the Transthyretin Amyloidosis Outcomes Survey (THAOS): 14-year update

Orphanet Journal of Rare Diseases, 2022
Background Transthyretin amyloidosis (ATTR amyloidosis) is a rare, life-threatening disease caused by the accumulation of variant or wild-type (ATTRwt amyloidosis) transthyretin amyloid fibrils in the heart, peripheral nerves, and other tissues and ...
A. Dispenzieri, T. Coelho, I. Conceição, M. Waddington-Cruz, J. Wixner, A. Kristen, C. Rapezzi, V. Planté-Bordeneuve, J. González-Moreno, M. Maurer, M. Grogan, Doug Chapman, L. Amass, Pablo Garcia Ivaylo Jose Gonzalez Maria Alejandra Gonzal Pavia Tarnev Costello Briseno Schmidt Drachman Bar, P. G. Pavía, Ivaylo Tarnev, J. Costello, Maria Alejandra González-Duarte Briseño, H. Schmidt, B. Drachman, F. Barroso, T. Yamashita, O. Lairez, Y. Sekijima, G. Vita, E. Jeon, M. Hanna, D. Slosky, M. Luigetti, S. Lorusso, F. Beamud, D. Adams, H. Moelgaard, R. Press, C. Cirami, H. Nienhuis, J. M. Plana, J. Inamo, D. Jacoby, M. Emdin, D. Quan, S. Hummel, R. Witteles, A. Dori, Sanjiv Shah, D. Lenihan, O. Azevedo, S. Murali, S. Živković, S. Low, J. Nativi-Nicolau, N. Fine, J. Tallaj, C. Tschoepe, R. Torrón, M. Polydefkis, G. Merlini, S. Bădeliță, Stephen S. Gottlieb, J. Tauras, E. B. Correia, H. Ventura, B. Gess, F. Darstein, Jeeyoung Oh, Tessa Marburger, J. Van Cleemput, V. Salutto, Y. Parman, C. Chao, N. Sarswat, Christopher Mueller, D. Steidley, J. Ralph, A. Warner, W. Cotts, J. Hoffman, M. Rugiero, S. Misawa, J. L. Blanco, L. G. Dávila, M. Sadeh, Jinju Luo, T. Kyriakides, Annabel K. Wang, H. Kaufmann, S. Živković   +86 more
semanticscholar   +1 more source

Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis

Frontiers in Molecular Biosciences, 2022
Hereditary (variant) transthyretin amyloidosis (ATTRv amyloidosis), which is caused by variants in the transthyretin (TTR) gene, leads to TTR amyloid deposits in multiple organs and various symptoms such as limb ataxia, muscle weakness, and cardiac failure.
Hiroki Yamaguchi, Hiroki Yamaguchi, Hironori Kawahara, Hironori Kawahara, Noriyuki Kodera, Ayanori Kumaki, Yasutake Tada, Yasutake Tada, Zixin Tang, Kenji Sakai, Kenjiro Ono, Masahito Yamada, Masahito Yamada, Rikinari Hanayama, Rikinari Hanayama   +14 more
openaire   +3 more sources

Senile Systemic Amyloidosis: Clinical Features at Presentation and Outcome [PDF]

, 2013
Background Cardiac amyloidosis is a fatal disease whose prognosis and treatment rely on identification of the amyloid type. In our aging population transthyretin amyloidosis (ATTRwt) is common and must be differentiated from other amyloid types.
Banypersad, SM, Dungu, J, Gibbs, SD, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Lachmann, HJ, McCarthy, CA, Petrie, A, Pinney, JH, Rowczenio, D, Sattianayagam, P, Venner, CP, Wassef, N, Wechalekar, A, Whelan, CJ   +15 more
core   +1 more source

Systemic embolism in amyloid transthyretin cardiomyopathy

European Journal of Heart Failure, 2022
Although systemic embolism is a potential complication in transthyretin amyloid cardiomyopathy (ATTR‐CM), data about its incidence and prevalence are scarce.
S. Vilches, M. Fontana, E. Gonzalez-Lopez, L. Mitrani, G. Saturi, Mary Renju, J. Griffin, A. Caponetti, S. Gnanasampanthan, Jeffeny De los Santos, C. Gagliardi, A. Rivas, F. Domínguez, S. Longhi, C. Rapezzi, M. Maurer, J. Gillmore, P. García-Pavía   +17 more
semanticscholar   +1 more source