Results 71 to 80 of about 7,937 (220)

Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. Methods A retrospective analysis was conducted using the
Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri, Krittapoom Akrawinthawong, Janardhana Gorthi, Bijeta Keisham, Tarun Dasari   +7 more
wiley   +1 more source

Early-stage amyloid transthyretin cardiomyopathy: uncertainties and opportunities

European Heart Journal, 2022
This editorial refers to ‘Characteristics and natural history of early-stage cardiac transthyretin amyloidosis’, by S. Law et al., https://doi.org/10.1093/eurheartj/ehac259. Amyloid transthyretin cardiomyopathy (ATTR-CM) used to be considered a rare disorder whose diagnosis required a tissue biopsy and which had no treatment options.
Rapezzi C., Serenelli M., Aimo A.
openaire   +3 more sources

Negative [99mTc]Tc ‐DPD Scintigraphy, Presence of Monoclonal Protein and Biopsy Suggestive of AL Amyloidosis in a Patient With Homozygous p.Ala101Val Transthyretin Gene Variant

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amyloidosis is a rare disease associated with the deposition of misfolded proteins that damage multiple organs, leading to a wide range of symptoms. The most frequently implicated proteins in amyloidosis include immunoglobulin Free Light Chains (FLC), related to AL amyloidosis, and transthyretin (TTR), which is responsible for ATTR amyloidosis.
Paulina Kryszpin, Piotr Jachimowski, Łukasz Augustowski, Mateusz Ziarkiewicz, Grzegorz Basak, Marta Lipowska, Marta Legatowicz‐Koprowska, Bogna Ziarkiewicz‐Wróblewska, Monika Gawor‐Prokopczyk   +8 more
wiley   +1 more source

Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review. [PDF]

, 2016
Cardiovascular Magnetic Resonance is increasingly used to differentiate the aetiology of cardiomyopathies. Late Gadolinium Enhancement (LGE) is the reference standard for non-invasive imaging of myocardial scar and focal fibrosis and is valuable in the ...
A Gulati, AM Maceira, C Parsai, CT Sibley, D Carrick, D Carrick, Daniel R. Messroghli, David A. Broadbent, DC Look, DM Sado, DM Sado, DM Sado, DO h-Ici, DR Messroghli, E Dall’Armellina, F aus dem Siepen, FL Ruberg, G Todiere, GC Fonarow, H Xue, H Xue, JA McCrohon, JC Moon, JM Bakker de, JN Dungu, John P. Greenwood, JP Carpenter, JT Clarke, K Chow, KS Patel, M Fontana, M Ugander, MG Friedrich, MS Maron, MY Su, N Kawel, N Kawel-Boehm, NA Ntusi, NA Ntusi, P Gujja, P Kellman, P Kellman, Pankaj Garg, Philip Haaf, PP Swoboda, RB Thompson, RJ Kim, S Dass, S Weingärtner, SK Piechnik, SM Banypersad, Sven Plein, UK Radunski, VM Ferreira, VM Ferreira, VM Ferreira, VO Puntmann, WG Hundley, Y Kobayashi   +58 more
core   +3 more sources

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients

JACC: Basic to Translational Science
Summary: Amyloidogenic transthyretin (ATTR) amyloidosis is a relentlessly progressive disease caused by the misfolding and systemic accumulation of amyloidogenic transthyretin into amyloid fibrils.
Rose Pedretti, BS, Lanie Wang, BS, Anna Yakubovska, MS, Qiongfang S. Zhang, BS, Binh Nguyen, PhD, Justin L. Grodin, MD, Ahmad Masri, MD, Lorena Saelices, PhD   +7 more
doaj   +1 more source

Establishment of an induced pluripotent stem cell line PUMCHi004-A from a hereditary transthyretin amyloid cardiomyopathy patient with transthyretin (TTR) p.Asp38Asn mutation

Stem Cell Research, 2020
Hereditary transthyretin amyloid cardiomyopathy is cardiac involvement in systemic transthyretin amyloidosis. For the first time, we generated induced pluripotent stem cell (iPSC) line of hATTR-CM carrying the TTR mutation p.Asp38Asn.
Shan He, Ye Jin, Zhuang Tian, TianRui Hua, HaiPing Xing, ShengSheng Zhuang, XinYue He, HanYu Li, Lun Wang, ShuYang Zhang   +9 more
doaj   +1 more source

Rapid progression of aortic and mitral stenosis in a patient with AA amyloidosis: a case report [PDF]

, 2019
Background: Aortic stenosis is a common finding in cardiac amyloidosis (CA). Younger patients often remain asymptomatic. If unrecognized, this can lead to serious complications such as heart failure.
Frumkin, David, Knebel, Fabian, Stangl, Karl, Taube, Eliane Tabea   +3 more
core   +1 more source

Cerebrovascular Involvement in Transthyretin Amyloid Cardiomyopathy

Journal of Clinical Medicine
Background: Intracardiac thrombosis is common in transthyretin amyloid cardiomyopathy (ATTR-CM), and patients are at risk for thromboembolic events. However, silent cerebral infarcts and the extent of cerebral small vessel disease in patients with cardiac amyloidosis are unknown.
Lukas Haider, Lore Schrutka, Emanuele Tommasino, Nicolas Avanzini, Sven Hauck, Nikolaus Nowak, Christian Hengstenberg, Diana Bonderman, Majda Thurnher   +8 more
openaire   +2 more sources

Conservative Management of Bilateral Spontaneous Pneumothorax

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Bilateral simultaneous spontaneous pneumothorax is a rare occurrence that generally requires prompt intervention. We report a case of simultaneous bilateral spontaneous pneumothorax that was conservatively managed. ABSTRACT Bilateral simultaneous spontaneous pneumothorax is a rare occurrence that generally requires prompt intervention. We report a case
Hanson Siu, Chuan T. Foo
wiley   +1 more source