Results 81 to 90 of about 231,717 (193)

Current and Evolving Multimodality Cardiac Imaging in Managing Transthyretin Amyloid Cardiomyopathy. [PDF]

Amyloid transthyretin (ATTR) amyloidosis is a protein-misfolding disease characterized by fibril accumulation in the extracellular space that can result in local tissue disruption and organ dysfunction. Cardiac involvement drives morbidity and mortality,
Caobelli, Federico, Stämpfli, Simon F, Shiri, Isaac, Falk, Rodney H, Kwong, Raymond Y, Benz, Dominik C, Cuddy, Sarah A M, Dobner, Stephan, Alwan, Louhai, Reyes, Mauricio, Dorbala, Sharmila, Bernhard, Benedikt, Gräni, Christoph, Eberli, Franz   +13 more
core   +2 more sources

A strange case of transthyretin cardiac amyloidosis in the ederly: a diagnostic challenge

, 2023
Transthyretin (TTR)-related cardiac amyloidosis is a progressive infiltrative cardiomyopathy that mimics hypertensive, hypertrophic heart disease and may go undiagnosed.
Anna Mengoni, Erica Rocco, Giuseppina Sasso, Giuseppe Ambrosio, P. Biagioli, G. Sasso, B. Simeone, Cinzia Zuchi, C. Zuchi, A. Mengoni, F. Scavelli, G. Ambrosio, Beatrice Simeone, Paolo Biagioli, Erberto Carluccio, Francesca Scavelli, E. Rocco, Rosanna Lauciello, R. Lauciello, E. Carluccio   +19 more
core   +1 more source

Protein mis-folding and human disease

, 2010
Serum Amyloid P Component (SAP), a putative molecular chaperone, is a homopentamericplasma protein of 25kDa subunits. It binds to the amyloid fibrils ofmisfolded proteins, which cause amyloidosis in humans. SAP not only stabilizesamyloid fibrils but also
Pal, Mohinder
core   +1 more source

High profile transvalvular microaxial flow pump as a bridge to heart transplantation for amyloid cardiomyopathy: A case series

JHLT Open
Background: The definitive treatment for end-stage heart failure (ESHF) due to amyloid cardiomyopathy (ACM) is an orthotopic heart transplant (OHT).
Pankaj Garg, MBBS, Mohammad Alomari, MD, Ishaq Wadiwala, MBBS, Melissa Lyle, MD, Si Pham, MD, Nafiye Busra Celik, MD, Juan C. Leoni Moreno, MD, Rohan Goswami, MD, Kevin Landolfo, MD, Jose Nativi-Nicolau, MD, Daniel Yip, MD, Parag C. Patel, MD, Basar Sareyyupoglu, MD   +12 more
doaj   +1 more source

Transthyretin cardiac amyloidosis: an update on diagnosis and treatment

ESC Heart Failure, 2019
Transthyretin cardiac amyloidosis (ATTR‐CA) demonstrates progressive, potentially fatal, and infiltrative cardiomyopathy caused by extracellular deposition of transthyretin‐derived insoluble amyloid fibrils in the myocardium.
Hiroyuki Yamamoto, Tomoki Yokochi
doaj   +1 more source

Contributions of Animal Models to the Mechanisms and Therapies of Transthyretin Amyloidosis

Frontiers in Physiology, 2019
Transthyretin amyloidosis (ATTR amyloidosis) is a fatal systemic disease caused by amyloid deposits of misfolded transthyretin, leading to familial amyloid polyneuropathy and/or cardiomyopathy, or a rare oculoleptomeningeal amyloidosis.
Ridwan Babatunde Ibrahim, Ridwan Babatunde Ibrahim, Yo-Tsen Liu, Yo-Tsen Liu, Yo-Tsen Liu, Yo-Tsen Liu, Ssu-Yu Yeh, Jin-Wu Tsai, Jin-Wu Tsai   +8 more
doaj   +1 more source

Prevalence of Transthyretin Amyloid Cardiomyopathy in Pacemaker Patients

ESC Heart Failure
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR-CM) is characterized by increased wall thickness, diastolic dysfunction and progressive heart failure symptoms. The disease may infiltrate the conduction system leading to conduction disturbances requiring an implantation of permanent ...
Aaseth, Eirik, Christiansen, Jon Runar
openaire   +4 more sources

The Red Flags Were Missing, the Indication Was Not: Genetic Testing in Heart Failure and Cardiomyopathy

Methodist DeBakey Cardiovascular Journal
Genetic testing is the step most often omitted once a cardiomyopathy has been characterized and the step most often misapplied when it is extended to people who have no phenotype.
Abou Bakr Salama
doaj   +1 more source

Total atrial conduction time predicts new-onset atrial fibrillation in patients with transthyretin amyloid cardiomyopathy

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative cardiomyopathy resulting from age-related failure of homoeostatic mechanisms in wild-type ATTR (wtATTR-CM) or destabilizing mutations in variant TTR (vATTR-CM). Atrial fibrillation (AF) is
Melpignano, Angelo, Fabbri, Gioele, Campo, Gianluca, Izzo, Carmen, Serenelli, Matteo, Guidi Colombi, Gabriele, Bertini, Matteo, Arzenton, Matteo, Cantone, Anna, Dal Passo, Beatrice, Pavasini, Rita, Marchini, Federico, Bonini, Jacopo   +12 more
core   +1 more source

Amyloid cardiomyopathy

, 2020
Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding ...
Thomas, Liza, Bart, Nicole K., Stewart, Graeme J., Korczyk, Dariusz, Atherton, John J., Fatkin, Diane   +5 more
core   +1 more source