Results 71 to 80 of about 231,717 (193)

Cardiac Amyloidosis: Mutimodality Imaging for Diagnosis and Prognosis

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging
Cardiac amyloid cardiomyopathy (CM) is a rapidly progressive disease that is frequently underrecognized and frequently diagnosed late in a significant number of individuals suffering from heart failure.
Nitin J. Burkule
doaj   +1 more source

Emerging Therapeutics for the Treatment of Light Chain and Transthyretin Amyloidosis

JACC: Basic to Translational Science, 2019
Summary: Cardiac amyloidosis is a restrictive cardiomyopathy that results from the deposition of misfolded light chain or transthyretin proteins, most commonly, in cardiac tissue.
Kathleen W. Zhang, MD, Keith E. Stockerl-Goldstein, MD, Daniel J. Lenihan, MD   +2 more
doaj   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Kidney Outcomes in Transthyretin Amyloid Cardiomyopathy

JAMA Cardiology
ImportanceTransthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cardiomyopathy that commonly presents with concomitant chronic kidney disease. Chronic kidney dysfunction is associated with worse outcomes, but the prognostic value of changes in kidney function over time has yet to be defined.ObjectiveTo assess the prognostic importance of a ...
Ioannou, Adam, Razvi, Yousuf, Porcari, Aldostefano, Rauf, Muhammad U., Martinez-Naharro, Ana, Venneri, Lucia, Kazi, Salsabeel, Pasyar, Ali, Luxhøj, Carina M., Petrie, Aviva, Moody, William, Steeds, Richard P., Sperry, Brett W., Witteles, Ronald M., Whelan, Carol, Wechalekar, Ashutosh, Lachmann, Helen, Hawkins, Philip N., Solomon, Scott D., Gillmore, Julian D., Fontana, Marianna   +20 more
openaire   +2 more sources

Systemic Amyloidosis With Probable Cardiac Involvement: Diagnostic Approach in a Resource‐Limited Setting: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Histopathological examination of an abdominal fat pad core needle biopsy demonstrating Congo red–positive amyloid deposition, confirming systemic amyloidosis. Representative photomicrographs illustrate characteristic amyloid deposits at low‐ and high‐power magnification.
Malegna Temesgen Garuma, Yonatan Debebe Regassa, Sifessa Dessalegn Demshasha   +2 more
wiley   +1 more source

Specific Therapy in Transthyretin Amyloid Cardiomyopathy: Future Perspectives Beyond Tafamidis

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a relatively prevalent cause of morbidity and mortality. Over the recent years, development of disease-modifying treatments has enabled stabilization of the circulating transthyretin tetramer and ...
Porcari, Aldostefano, Sinagra, Gianfranco, Dore, Franca, Allegro, Valentina, Saro, Riccardo, Merlo, Marco   +5 more
core   +1 more source

Selection of hereditary transthyretin amyloid patients for liver transplantation : the Swedish experience

, 2012
Liver transplantation (LTx) is currently an accepted treatment for hereditary transthyretin amyloidosis (h-ATTR). However, to optimize the outcome, careful selection of patients is required, since increased mortality compared with that found for ...
Suhr, Ole B,, Ericzon, B-G, Ericzon, Bo-Göran, Suhr, OB   +3 more
core   +1 more source

Oral Therapy for the Treatment of Transthyretin-Related Amyloid Cardiomyopathy

, 2022
The care of systemic amyloidosis has improved dramatically due to improved awareness, accurate diagnostic tools, the development of powerful prognostic and companion biomarkers, and a continuous flow of innovative drugs, which translated into the ...
Merlini, Giampaolo, Maria Girelli, Girelli, Maria, Giampaolo Merlini, Nuvolone, Mario, Mario Nuvolone   +5 more
core   +1 more source

Early‐Onset Wild‐Type Transthyretin Amyloidosis Polyneuropathy

Muscle &Nerve, Volume 74, Issue 5, Page 1471-1475, November 2026.
Chafic Karam, Kaylee Baker, Sami Khella, Brian Drachman, Pranav Chandrashekar, MacLean Nasrallah, Shunsuke Koga, Janice Pieretti   +7 more
wiley   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source