Results 131 to 140 of about 1,227 (255)

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Soft Skills as a Tool for Post-Pandemic Sustainability: A University-Based Study. [PDF]

Int J Environ Res Public Health
De Carlo E, Ingusci E, Catalano AA, Signore F.   +3 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Soft skills during residency in Spain: an analysis of the specialized training programmes. [PDF]

BMC Med Educ
Sánchez-Peralta LF, Pagador JB, Sánchez Margallo FM.   +2 more
europepmc   +1 more source

A MODEL FOR DEVELOPING TRANSVERSAL-METHODOLOGICAL COMPETENCIES IN FUTURE EDUCATORS

The modernization of higher education in Uzbekistan until 2030 aims to develop independent learning, critical thinking, and entrepreneurial skills. The competency-based approach enhances professional competence through innovative pedagogical technologies.
openaire   +2 more sources

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Identifying core teamwork competencies for community-based health and social care professionals: an e-Delphi study. [PDF]

BMC Med Educ
Aleo G, Pagnucci N, Walsh N, Moriarty F, Giardulli B, Koutra K, Przyłęcki P, Fitzgerald C, Illing J.   +8 more
europepmc   +1 more source

Competence assessment rubric in the Physiotherapy Practicum. [PDF]

PLoS One, 2022
Martiáñez-Ramírez NL, Pineda-Galán C, Rodríguez-Bailón M, Romero-Galisteo RP.   +3 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Evaluating Patient Safety Competency Acquisition Through Clinical Simulation: Development and Application of the Clinical Simulation Learning Patient Safety Scale. [PDF]

Nurs Res Pract
Ramírez-Baraldes E, García-Gutiérrez D, Romero-Saldaña M, Diez-Caballero BR, González-Moret R, Picher-Martínez M, García-Salido C.   +6 more
europepmc   +1 more source