Results 121 to 130 of about 74,349 (302)

Diseño de un estudio poblacional del riesgo cardiovascular en Castilla y León a través de los equipos de atención primaria Design of a population-based study of cardiovascular risk in Castile and Leon (Spain) through primary care teams

open access: yesGaceta Sanitaria, 2007
Se describe el diseño y los indicadores de respuesta de un estudio transversal para estimar diferentes parámetros del riesgo cardiovascular en la población de Castilla y León. Se obtuvo una muestra de 4.950 personas de 15 y más años de edad en dos etapas:
A. Tomás Vega Alonso   +5 more
doaj  

Co-diseño de prácticas educativas abiertas en una universidad a distancia / Co-design of open educational practices in a distance university

open access: yesRevista Latinoamericana de Tecnología Educativa, 2019
Este artículo se centra en el análisis de un proceso co-diseño de prácticas educativas abiertas (PEA) para el desarrollo de competencias transversales en el contexto de una universidad a distancia.
Mildred Acuña-Sossa   +1 more
doaj   +1 more source

OPTIMAL KINEMATIC DESIGN OF A CAR AXLE GUIDING MECHANISM IN MBS SOFTWARE ENVIRONMENT [PDF]

open access: yesFiabilitate şi Durabilitate, 2015
This work deals with the optimal kinematic design of the guiding mechanism used for the rear axle of a motor vehicle. A guiding mechanism of type 2S1C (S - sphere, C - circle) is taken into consideration, the optimization study being conducted by using
Cătălin ALEXANDRU
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Transversal Competencies in Operating Room Nurses: A Hierarchical Task Analysis

open access: yesNursing Reports
Background: Ensuring the safety of patients in the operating room, through the monitoring and prevention of adverse events is a central priority of healthcare delivery.
Francesca Reato   +8 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

PoolHiTS: A Shifted Transversal Design based pooling strategy for high-throughput drug screening-1

open access: yes, 2011
Brary size (= 100) and expected number of positives (= 3) fixed. The inset shows the variation in number of test needed () with the same parameter , for a = 0 to 20 and = 44 to 1852.Copyright information:Taken from "poolHiTS: A Shifted Transversal Design
Raghunandan M Kainkaryam (87719)   +1 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Rettangoli latini e “transversal designs” con parallelismo

open access: yes, 1979
A complete system of mutually orthogonal latin rectangles is defined here as in [1] and [2]. A resolvable transversal design (RTD). as defined here, is a transversal design in the sense of [3], provided there is λ=1 and there exists a parallelism (i.e.
QUATTROCCHI, Pasquale   +1 more
core  

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