Results 31 to 40 of about 4,928 (175)
Journal of Pharmacy & Pharmaceutical Sciences, 2008 PURPOSE. To compare phenelzine (PLZ), an antidepressant drug with anxiolytic properties which inhibits monoamine oxidase (MAO) but also elevates rat brain levels of the amino acids ?-aminobutyric acid (GABA) and alanine (ALA), with vigabatrin (VIG ...
Kathryn G. Todd, Glen B. Baker
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Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Cell Communication and Signaling, 2018 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies.
Keri Callegari +3 more
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Metabolites, 2022 Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells.
Yuki Tabata, Yoshihiro Shidoji
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Neurogenic Stuttering and Lateralized Motor Deficits Induced by Tranylcypromine
Behavioural Neurology, 1994 A case of neurogenic stuttering induced by the monoamine oxidase inhibitor tranylcypromine is described. The association of neurogenic stuttering with acquired lateralized motor deficits in the patient described is discussed with reference to current ...
J. D. Duffy
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Anti-cancer effect of LINC00478 in bladder cancer correlates with KDM1A-dependent MMP9 demethylation
Cell Death Discovery, 2022 Accumulating evidence has highlighted the important roles of long intergenic non-coding RNAs (lincRNAs) during cancer progression. However, the involvement of LINC00478 in bladder cancer remains largely unclear.
Han-Jie Yang, Tian Liu, Yang Xiong
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Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line. [PDF]
PLoS ONE, 2010 Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development.
Maren Godmann, Erin May, Sarah Kimmins
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Maternal &Child Nutrition, EarlyView.Maternal brewer's yeast supplementation did not change the milk oligosaccharide (HMO) concentration, but more mothers felt their milk supply was increased, and fewer reported formula use by 6 months postpartum compared to those taking the placebo. This suggests the supplement may support breastfeeding, warranting further investigation in larger trials.
Lili Jia, Louise Brough, Janet L. Weber
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Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
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Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Tranylcypromine: a promising repurposed drug against Leishmaniases
Frontiers in MicrobiologyLeishmaniases remain a major global health challenge due to limited and often toxic therapeutic options. Recent advances in artificial intelligence have enabled the identification of novel antileishmanial candidates through drug repurposing approaches ...
Rafeh Oualha +4 more
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