Results 21 to 30 of about 547,460 (150)

Association of the mtDNA m.4171C>A/MT-ND1 mutation with both optic neuropathy and bilateral brainstem lesions [PDF]

, 2014
Background: An increasing number of mitochondrial DNA (mtDNA) mutations, mainly in complex I genes, have been associated with variably overlapping phenotypes of Leber’s hereditary optic neuropathy (LHON), mitochondrial encephalomyopathy with stroke ...
Cristina Scaduto, Tonon C, Caporali L, NASSETTI, STEFANIA-ALESSANDRA, Daniela Brunetto, Nassetti, Stefania, Raffaele Lodi, Tonon, Caterina, Francesco Toni, Stipa C, Carelli V., D. Brunetto, Antonio Torroni, A. Torroni, Caterina Tonon, Leonardo Caporali, F. Gandini, Chiara La Morgia, Toni, Francesco, Toni F, Nassetti S, Lodi R, Brunetto D, Anna Olivieri, Francesca Gandini, La Morgia C, Brunetto, Daniela, Parmeggiani, Antonia, Carlotta Stipa, Gandini, Francesca, Scaduto C, C. Scaduto, Stefania Nassetti, Valerio Carelli, Stipa, Carlotta, Carelli, Valerio, Scaduto, Cristina, Lodi, Raffaele, La Morgia, Chiara, Antonia Parmeggiani, Caporali, Leonardo, Torroni, Antonio, Olivieri, Anna, A. Olivieri, Parmeggiani A   +44 more
core   +2 more sources

The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity [PDF]

, 2009
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors ...
Achilli Alessandro, GHELLI, ANNA MARIA, Mattioli Stefano, Pala M., Barbieri, Anna, Vidoni S., Torroni Antonio, Carelli Valerio, Anna Barbieri, Vidoni, Sara, Valerio Carelli, Carelli, Valerio, Ghelli, Anna, Mattioli, Stefano, Torroni, Antonio, Iommarini, Luisa, Zanna, Claudia, Pala, Maria, Vidoni Sara, Stefano Mattioli, Antonio Torroni, Achilli A., ZANNA C, Porcelli Anna Maria, Zanna Claudia, Pala Maria, MATTIOLI S, Luisa Iommarini, GHELLI A, Achilli, Alessandro, IOMMARINI L, Rugolo, Michela, Torroni A., Porcelli, Anna Maria, CARELLI V., Ghelli Anna, Rugolo Michela, BARBIERI A, RUGOLO M, PORCELLI AM, Anna Ghelli, Barbieri Anna, Sara Vidoni, Maria Pala, Alessandro Achilli, Anna Maria Porcelli, Michela Rugolo, Claudia Zanna, Iommarini Luisa, VIDONI S   +49 more
core   +1 more source

SPECTRUM OF OPTIC NEUROPATHIES PRESENTING IN NEUROOPHTHALMOLOGY CLINIC AT AFIO

Pakistan Armed Forces Medical Journal, 2021
Objective: To study the spectrum of optic neuropathies in patient’s presenting at AFIO Rawalpindi. Study Design: Descriptive study/retrospective study.
Umer Ijaz, Asad Habib, Hassan Sajjad Rathore, Muhammad Imran Sarwar Khan   +3 more
doaj   +1 more source

Blunt Facial Trauma Causing Isolated Optic Nerve Hematoma

Case Reports in Radiology, 2013
Traumatic optic neuropathy is an uncommon, yet serious, result of facial trauma. The authors present a novel case of a 59-year-old gentleman who presented with an isolated blunt traumatic left optic nerve hematoma causing vision loss. There were no other
R. Parab, C. I. Fung, Gerrit Van Der Merwe   +2 more
doaj   +1 more source

Indirect Traumatic Optic Neuropathy with Associated Charles Bonnet Syndrome

TNOA Journal of Ophthalmic Science and Research, 2022
We report a case of an 84-year-old female who presented following a fall from standing height. There was immediate loss of vision in the right eye. On day 3 of admission, the patient described seeing hallucinations in the right eye.
Shenouda Girgis, Aditya Sethi, Sahebaan Sethi, Vaibhav Sethi, Reena Sethi, Arun Sethi   +5 more
doaj   +1 more source

Value of neurohumoral dysfunction in the pathogenesis of traumatic optic neuropathy

Journal of Ophthalmology, 2019
Background: It is not known in which way neurohumoral properties of the hypothalamus undergo changes due to traumatic optic nerve neuropathy (TON). Purpose: To investigate the value of neurohumoral dysfunction in the pathogenesis of TON.
N.M. Moyseyenko
doaj   +1 more source

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies

Molecular Therapy: Nucleic Acids, 2023
Optic neuropathy is a group of optic nerve (ON) diseases with progressive degeneration of ON and retinal ganglion cells (RGCs). The lack of neuroprotective treatments is a central challenge for this leading cause of irreversible blindness. SARM1 (sterile
Pingting Liu, Wei Chen, Haowen Jiang, Haoliang Huang, Liping Liu, Fang Fang, Liang Li, Xue Feng, Dong Liu, Roopa Dalal, Yang Sun, Paymaan Jafar-Nejad, Karen Ling, Frank Rigo, Jiangbin Ye, Yang Hu   +15 more
doaj   +1 more source

The transcorneal electrical stimulation as a novel therapeutic strategy against retinal and optic neuropathy: a review of experimental and clinical trials [PDF]

International Journal of Ophthalmology, 2016
Transcorneal electrical stimulation (TES) is a novel therapeutic approach to activate the retina and related downstream structures. TES has multiple advantages over traditional treatments, such as being minimally invasive and readily applicable in a ...
Ye Tao, Tao Chen, Bei Liu, Li-Qiang Wang, Guang-Hua Peng, Li-Min Qin, Zhong-Jun Yan, Yi-Fei Huang   +7 more
doaj   +1 more source

Mitochondrial lipid profiling data of a traumatic optic neuropathy model

Data in Brief, 2020
Traumatic optic neuropathy (TON) is a degenerative process that occurs in a subset of patients following blunt force trauma to the head. This condition is characterized by retinal ganglion cell (RGC) death and axon degeneration within the optic nerve [1].
Ronaldo Nuesi, Ryan A. Gallo, Sean D. Meehan, John V. Nahas, Galina Dvoriantchikova, Daniel Pelaez, Sanjoy K. Bhattacharya   +6 more
doaj   +1 more source

Our Experience in Endoscopic Transnasal Optic Nerve Decompression

Bengal Journal of Otolaryngology and Head Neck Surgery
INTRODUCTION: Traumatic optic neuropathy (TON), a severe complication following head injury, affects about 0.5% to 5% of patients with closed head injuries.1 Visual acuity (VA) loss associated with TON can be partial or complete and temporary or ...
Saravana Selvan Velmurugan , VIVEK Mariappan, Mohamed Siddique Samsudeen, SURESH KUMAR Narayanan, Asith Jakkiriya Basha, Revathi Subramanian   +5 more
doaj   +1 more source