Results 101 to 110 of about 1,163,365 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

QUALITATIVE RESEARCH IN TRAVEL BEHAVIOR STUDIES

open access: yesLibro de Actas CIT2016. XII Congreso de Ingeniería del Transporte, 2016
Qualitative methodology is extensively used in a wide range of scientific areas, such as Sociology and Psychology, and it is been used to study individual and household decision making processes. However, in the Transportation Planning and Engineering domain it is still infrequent to find in the travel behavior literature studies using qualitative ...
Mars, Lidón, Arroyo, Rosa, Ruiz, Tomás
openaire   +5 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The roots of racialized travel behavior

open access: yes, 2021
Transportation inequities, particularly in the United States, result in part from historical and contemporary racism in planning, policy, urban development, decision making, and societal institutions. They have limited the mobility and access to opportunity for Black, Indigenous, and people of color, and shaped the ways that they travel.
openaire   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Quantifying the impact of COVID-19 on travel behavior in different socio-economic segments. [PDF]

open access: yesTransp Policy (Oxf), 2023
Xi H, Li Q, Hensher DA, Nelson JD, Ho C.
europepmc   +1 more source

Selfishness and Altruism in the Distribution of Travel Time and Income [PDF]

open access: yes
Most economic models assume that individuals act out their preferences based on their own self interest. However there have also been other paradigms in the economics literature that have tried to capture alternative manifestations of human behavior that
David Levinson, Nebiyou Tilahun
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Intersection of Urban Form and Mileage Fees: Findings from the Oregon Road User Fee Pilot Program, Research Report 10-04 [PDF]

open access: yes, 2011
This report analyzes data from the 2006-2007 Oregon Road User Fee Pilot program to assess if and how urban form variables correlate with travel behavior changes that participants made in response to the mileage-based fee program. It finds that charging a
Agrawal, Asha Weinstein   +3 more
core   +1 more source

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