Results 91 to 100 of about 1,163,658 (291)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Addressing brain metabolic connectivity in treatment-resistant schizophrenia: a novel graph theory-driven application of 18F-FDG-PET with antipsychotic dose correction

Schizophrenia
Few studies using Positron Emission Tomography with 18F-fluorodeoxyglucose (18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in schizophrenia, primarily focusing on metabolic activity, with none investigating connectivity ...
Giuseppe De Simone, Felice Iasevoli, Annarita Barone, Valeria Gaudieri, Alberto Cuocolo, Mariateresa Ciccarelli, Sabina Pappatà, Andrea de Bartolomeis   +7 more
doaj   +1 more source

Treatment resistant depression

Sri Lanka Journal of Psychiatry, 2018
No abstract ...
D. Ariyasinghe, S. S. Williams
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Conditional Beliefs of Primary-Care Patients with Treatment-Resistant Depression [PDF]

, 2015
Background:Cognitive behaviour therapy (CBT) for patients with treatment-resistant depression (TRD) aims to reframe underlying conditional beliefs that are thought to maintain depression.Aim:To systematically explore conditional beliefs expressed by ...
Burrage, Alex, Green, Samantha, Kuyken, Willem, Lewis, Glyn, Turner, Katrina, Wiles, Nicola, Williams, Chris   +6 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

In vivo assessment of GABAergic inhibition and glutamate facilitation in treatment-resistant schizophrenia: a TMS study integrating clinical, cognitive, and neurophysiological evaluations

Schizophrenia
Treatment-resistant schizophrenia (TRS) affects approximately one-third of individuals with schizophrenia, posing significant challenges for clinical management.
Annarita Barone, Gianmaria Senerchia, Giuseppe De Simone, Marco Manzo, Mariateresa Ciccarelli, Stefano Tozza, Valentina Virginia Iuzzolino, Myriam Spisto, Raffaele Dubbioso, Felice Iasevoli, Rosa Iodice, Andrea de Bartolomeis   +11 more
doaj   +1 more source

Lifetime Bipolar Disorder comorbidity and related clinical characteristics in patients with primary Obsessive Compulsive Disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) [PDF]

, 2019
IntroductionBipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course.
Benatti, Beatrice, Cirnigliaro, Giovanna, Dell'Osso, Bernado, Fineberg, Naomi, Grancini, Benedetta, Grassi, Giacomo, Hollander, Eric, Hranov, Georgi, Hranov, Luchezar, Karamustafalioglu, Oguz, Lanzagorta, Nuria, Lochner, Christine, Marazziti, Donatella, Menchon, Josè M, Nicolini, Humberto, Pallanti, Stefano, Rodriguez, Carolyn I, Stein, Dan J., Van Ameringen, Michael, Vismara, Matteo, Zohar, Joseph   +20 more
core   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Treatment resistant depression in primary care: Co-constructing difficult encounters [PDF]

, 2013
Many patients with depression do not recover despite medication or therapy. Individuals with treatment resistant depression often have co-morbid anxiety, personality difficulties and drug or alcohol misuse and have been characterised as difficult ...
Byng, R, McPherson, S, Oxley, D
core   +1 more source