Effects of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation on Serum Brain-Derived Neurotrophic Factor Levels in Patients with Depression [PDF]
, 2012 Objective: Brain-derived neurotrophic factor (BDNF) levels are decreased in individuals with depression and increase following antidepressant treatment. The objective of this study is to compare pre- and post-treatment serum BDNF levels in patients with ...
Laura eGedge +8 more
core +2 more sources
Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression : a systematic review and meta-analysis [PDF]
, 2014 Electroconvulsive therapy (ECT) is the longest standing psychiatric treatment available and has unequivocal benefit in severe depression. However this treatment comes with a number of side effects such as memory impairment.
Micallef-Trigona, Beppe
core +4 more sources
Effect of neurostimulation on cognition and mood in refractory epilepsy. [PDF]
, 2018 Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to ...
Chan, Alvin Y +3 more
core +1 more source
Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression
JAMA Network Open, 2022 Key Points Question Does 6 weeks of minocycline treatment as add-on to standard antidepressant treatment reduce depressive symptoms in patients with treatment-resistant depression? Findings In this randomized clinical trial of 168 patients with treatment-
J. Hellmann‐Regen +18 more
semanticscholar +1 more source
Treatment-resistant depression and its diagnosis and treatment
Sichuan jingshen weisheng, 2022 The aim of this study is to explore the diagnostic strategies and options for treatment-resistant depression （TRD）. Despite the well-established efficacy of antidepressants， 20%~30% of depressive patients in the clinic fail to respond or respond poorly ...
Hu Shaohua
doaj +1 more source
Informed consent decision-making in deep brain stimulation [PDF]
, 2018 Deep brain stimulation (DBS) has proved useful for several movement disorders (Parkinson’s disease, essential tremor, dystonia), in which first and/or second line pharmacological treatments were inefficacious.
Appelbaum +6 more
core +2 more sources
Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial [PDF]
, 2014 Background: Only one-third of patients with depression respond fully to treatment with antidepressant medication. However, there is little robust evidence to guide the management of those whose symptoms are 'treatment resistant'.<p></p> ...
Abel, Anna +22 more
core +3 more sources
Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials [PDF]
, 2006 Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory.
Carey, P +8 more
core +1 more source
Psychological Medicine, 2018 Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression.
Fernanda Palhano-Fontes +22 more
semanticscholar +1 more source
Antidepressant discontinuation in treatment resistant depression
Contemporary Clinical Trials Communications, 2019 Treatment-resistant depression (TRD) is a growing problem in psychiatric practice with some 15–20% of depressed patients becoming chronically depressed and perhaps as many as 40% in tertiary settings.
Ziad A. Ali +2 more
doaj +1 more source