Results 1 to 10 of about 75,341 (263)

Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study [PDF]

Brazilian Journal of Psychiatry, 2013
Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment ...
Bruno Bertolucci Ortiz, Gerardo Maria de Araújo Filho, Ary Gadelha de Alencar Araripe Neto, Daiane Medeiros, Rodrigo Affonseca Bressan   +4 more
doaj   +5 more sources

Distinct subcortical neuroanatomic profiles of treatment-resistant schizophrenia: structural magnetic resonance imaging study [PDF]

BJPsych Open
Background Understanding the neuroanatomical correlates of treatment response in schizophrenia is crucial for improving clinical stratification and clarifying underlying pathophysiological mechanisms.
Ibrahim Sungur, Simay Selek, Kaan Keskin, Asli Ceren Hinc, Furkan Yazici, Elif Ozge Aktas, Yigit Erdogan, Omer Kitis, Ali Saffet Gonul   +8 more
doaj   +2 more sources

Potential efficacy of dopaminergic antidepressants in treatment resistant anergic-anhedonic depression results of the chronic anergic-anhedonic depression open trial – CADOT

Frontiers in Psychiatry, 2023
IntroductionAmong treatment-resistant depression (TRD), we identified anergic-anhedonic clinical presentations (TRAD) as putatively responsive to pro-dopaminergic strategies.
Ludovic Christophe Dormegny-Jeanjean, Ludovic Christophe Dormegny-Jeanjean, Ludovic Christophe Dormegny-Jeanjean, Clément de Billy, Clément de Billy, Clément de Billy, Olivier Mainberger, Olivier Mainberger, Olivier Mainberger, Sébastien Weibel, Sébastien Weibel, Sébastien Weibel, Benoit Schorr, Benoit Schorr, Benoit Schorr, Alexandre Obrecht, Alexandre Obrecht, Lionel Landré, Fabrice Berna, Fabrice Berna, Jean-Baptiste Causin, Jean-Baptiste Causin, Jean-Baptiste Causin, Frederic Blanc, Frederic Blanc, Vlad Danila, Vlad Danila, Mihaela Tomsa, Mihaela Tomsa, Geraldine Pfleger, Geraldine Pfleger, Camille Meyer, Camille Meyer, Camille Meyer, Ilia Humbert, Ilia Humbert, Ilia Humbert, Hervé Javelot, Hervé Javelot, Guillaume Meyer, Guillaume Meyer, Gilles Bertschy, Gilles Bertschy, Gilles Bertschy, Jack Rene Foucher, Jack Rene Foucher, Jack Rene Foucher, Jack Rene Foucher   +47 more
doaj   +1 more source

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

eLife, 2021
We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant ...
Eilis Hannon, Emma L Dempster, Georgina Mansell, Joe Burrage, Nick Bass, Marc M Bohlken, Aiden Corvin, Charles J Curtis, David Dempster, Marta Di Forti, Timothy G Dinan, Gary Donohoe, Fiona Gaughran, Michael Gill, Amy Gillespie, Cerisse Gunasinghe, Hilleke E Hulshoff, Christina M Hultman, Viktoria Johansson, René S Kahn, Jaakko Kaprio, Gunter Kenis, Kaarina Kowalec, James MacCabe, Colm McDonald, Andrew McQuillin, Derek W Morris, Kieran C Murphy, Colette J Mustard, Igor Nenadic, Michael C O'Donovan, Diego Quattrone, Alexander L Richards, Bart PF Rutten, David St Clair, Sebastian Therman, Timothea Toulopoulou, Jim Van Os, John L Waddington, Wellcome Trust Case Control Consortium (WTCCC), CRESTAR consortium, Patrick Sullivan, Evangelos Vassos, Gerome Breen, David Andrew Collier, Robin M Murray, Leonard S Schalkwyk, Jonathan Mill   +47 more
doaj   +1 more source

Treatment-resistant schizophrenia: How far have we traveled?

Frontiers in Psychiatry, 2022
Treatment-resistant schizophrenia is a lack of adequate response to antipsychotic medications resulting in incomplete functional and social recovery from the illness.
Ambu Pandey, Kamal Narayan Kalita
doaj   +1 more source

DTI study of corpus callosum in schizophrenia patients with different treatment response

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Objective To compare the white matter fiber integrity of corpus callosum in schizophrenia patients with different treatment response with normal controls.
SHI Xiao⁃meng, HUANG Jia⁃shuang , GAO Shu⁃zhan , ZHANG Dao⁃qiang, XU Xi⁃jia   +4 more
doaj   +1 more source

Cortico-cognition coupling in treatment resistant schizophrenia

NeuroImage: Clinical, 2022
Background: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear.
Warda T. Syeda, Cassandra M.J. Wannan, Antonia H. Merritt, Jayachandra M. Raghava, Mahesh Jayaram, Dennis Velakoulis, Tina D. Kristensen, Rigas Filippos Soldatos, Shane Tonissen, Naveen Thomas, Karen S. Ambrosen, Mikkel E. Sørensen, Birgitte Fagerlund, Egill Rostrup, Birte Y. Glenthøj, Efstratios Skafidas, Chad A. Bousman, Leigh A. Johnston, Ian Everall, Bjørn H. Ebdrup, Christos Pantelis   +20 more
doaj   +1 more source

Treatment of early resistant schizophrenia: a case report

European Psychiatry, 2023
Introduction Early-onset schizophrenia begins before the age of 18. Drug treatments are mainly based on antipsychotics, preferably atypical antipsychotics, which have fewer side effects compared to first generation antipsychotics.
S. Benhammou, M. Raissouni, H. Kisra
doaj   +1 more source

Electroconvulsive therapy in treatment resistant schizophrenia: Old beacon of hope when nothing else works

European Psychiatry, 2022
Introduction Electroconvulsive therapy (ECT) is one of the oldest psychiatric treatments used to this day. It is particularly useful in cases of schizophrenia resistant to treatment with antipsychotics.
C. Adão, A.A. Quintão, A. Velosa, P. Trindade, C. Almeida   +4 more
doaj   +1 more source

Using the maternal immune stimulation model of schizophrenia to investigate the therapeutic efficacy of neuromodulation techniques [PDF]

, 2020
The present work used a neurodevelopmental rodent model of schizophrenia, namely the maternal immune stimulation (MIS) model, to study the potency of electrical neuromodulation techniques to ameliorate and even prevent schizophrenia-relevant behavioral ...
Hadar, Ravit
core   +1 more source