Results 141 to 150 of about 26,546 (243)

Commentary: Real-world effectiveness and safety of xanomeline and trospium for treatment-resistant schizophrenia in a state hospital system. [PDF]

Front Psychiatry
Price MZ, Price RL.
europepmc   +1 more source

The cardiac pacemakers: A paradigm of robustness in evolutionary biology

The Journal of Physiology, EarlyView.
Abstract figure legend Functional networks in living systems are formed by many thousands of gene products. In association with those networks, several genes (four in this diagram) may be sufficient, each on its own, to ensure that the function occurs. Any one of these may be removed or blocked while leaving the others to continue functioning.
Denis Noble
wiley   +1 more source

Differential Neuronal Development in iPSC‐Derived Neural Stem Cells From Monozygotic Twin Cases With Treatment‐Resistant Schizophrenia and Discordant Responses to Clozapine

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We investigated early neuronal development using iPSCs from twins with treatment‐resistant schizophrenia discordant for clozapine response. The non‐responder exhibited more pronounced impairment in differentiation than the responder. Transcriptomic analysis revealed distinct developmental gene expression profiles, suggesting that early ...
Shotaro Kawano, Sayaka Katayama, Masaya Ogawa, Rei Endo, Naoto Ikeda, Yuuri Ikeuchi, Tomoki Mita, Hikari Takei, Nanaka Gotoda‐Nishimura, Daiki Miura, Hotaka Fukushima, Hitoshi Hashimoto, Ryota Hashimoto, Takanobu Nakazawa   +13 more
wiley   +1 more source

Association Between Psychiatrists' Subjective Clinical Behavior Scores and Objective Quality Indicators Based on Discharge Prescriptions: A Nationwide Multicenter Study Based on the EGUIDE Project

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Association between quality indicators and clinical behaviors related to the guidelines for schizophrenia. ABSTRACT Aim Psychiatrists often perceive their clinical practices as guideline‐concordant; however, discrepancies frequently exist between perceived and actual prescribing behaviors.
Kazuhiko Yamamuro, Naomi Hasegawa, Yusuke Arai, Hikaru Hori, Hiroyuki Muraoka, Toru Horinouchi, Naoki Hashimoto, Shinichiro Ochi, Takashi Tsuboi, Hirotaka Yamagata, Junya Matsumoto, Satsuki Ito, Toshiaki Onitsuka, Kazutaka Ohi, Hisashi Yamada, Jun‐ichi Iga, Ken Inada, Koichiro Watanabe, Norio Yasui‐Furukori, Ryota Hashimoto   +19 more
wiley   +1 more source

Empowerment-based case management for treatment-resistant schizophrenia: a three-year single case report. [PDF]

Front Psychiatry
Wang C, Li X, Chen J, Li X, Hou W, Dong N.   +5 more
europepmc   +1 more source

Fingerprints Encode Risk for Bipolarity

Bipolar Disorders, Volume 28, Issue 3, May 2026.
ABSTRACT Background Fingerprint patterns are developed during pregnancy and share a common embryogenic origin with the central nervous system. Considering the observed relationship between prenatal abnormalities and higher risk for schizophrenia, we previously built fingerprint‐based algorithms achieving validation accuracies up to 70% in a large ...
Raymond Salvador, María Ángeles García‐León, Roberto Rodriguez‐Jimenez, Pablo Del Olmo‐Encabo, Lucila Barbosa, Ana Aquino‐Servín, Alejandro Sotero‐Moreno, Mar Fatjó‐Vilas, Nuria Jaurrieta‐Guarner, Manel Sánchez, Carmen Corte‐Souto, Ailín Rojo, Carlos Rebolleda‐Gil, Patricia Correa‐Ghisays, Vicent Balanzá‐Martínez, Cristian Caride‐Padilla, Salvador Sarró, Isabel Feria‐Raposo, Ángeles Sánchez‐Cabezudo, Olga Jiménez‐Rodríguez, María Llanos Torres, Ruben Moreno‐Comellas, Blanca Navarro, Francisco Del Olmo‐Romero, José Antonio Larraz‐Romeo, Edith Pomarol‐Clotet   +25 more
wiley   +1 more source

Real-world effectiveness and safety of xanomeline and trospium for treatment-resistant schizophrenia in a state hospital system. [PDF]

Front Psychiatry
Vadiei N, Crismon ML.
europepmc   +1 more source

Schizophrenia Genetics Modulates Clinical Depressive Features

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 3, Page 180-193, April 2026.
ABSTRACT Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.
Alessandro Serretti, Daniel Souery, Siegfried Kasper, Joseph Zohar, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Raffaele Ferri, Giuseppe Fanelli, Chiara Fabbri, Raffaella Zanardi, Francesco Benedetti, Bernhard T. Baune, Julien Mendlewicz   +13 more
wiley   +1 more source

Integrating Bioenergetic Therapy Model with Neuropsychopharmacological Interventions in Long-standing Treatment-resistant Schizophrenia: Case Series and Review of Literature. [PDF]

Ann Neurosci
Khairkar P, Chadha D, Kamble A, Khivsara A, Modi R, Khairkar R.   +5 more
europepmc   +1 more source

Electroconvulsive Therapy in Schizophrenia: Exploratory Study on the Efficacy, Cognitive Effects, and Safety of Right Unilateral Versus Bitemporal Techniques

Brain and Behavior, Volume 16, Issue 4, April 2026.
The purpose of the study was to compare the effectiveness, safety, and cognitive effects of BTS versus RUS in hospitalized patients with schizophrenia. The results should be considered preliminary due to the sample size (n = 17) and lack of blinding of participants.
Héctor O. Castañeda‐González, Alexandra Magaña‐Ornelas, Aurea Ruby Santiago‐Maury, Sophia Sánchez López, Iván de Jesús Leonor‐Hernández, Hector Cabello‐Rangel   +5 more
wiley   +1 more source