Psychological Factors and Treatment Adherence Behavior in Patients With Chronic Heart Failure [PDF]
, 2007 Background: Chronic heart failure adversely affects 300,000 Australians. Symptom stabilization and prognosis are partially determined by patients following medical and lifestyle recommendations.
Dwyer, Jonathan +2 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study
, 2009 A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures,
Huang, Yangxin, Lu, Tao
core +1 more source
Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]
, 2014 Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Danhof, M +6 more
core +1 more source
Treatment of acute renal failure [PDF]
Kidney International, 1998 Acute renal failure is a life threatening illness whose mortality has remained high since the introduction of hemodialysis 25 years ago, despite advances in supportive care. Acute renal failure is an extremely morbid and costly disorder with a significant proportion of patients progressing to end-stage renal disease requiring dialysis.
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The Defensive Effect of Medical Practice Policies in Malpractice Litigation [PDF]
, 1991 The theoretical prospects for medical practice policies to reform malpractice law by giving conclusive defensive effect to medical custom were studied.
Hall, Mark A.
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Urate-lowering therapy and kidney outcomes in patients with chronic kidney disease and hyperuricemia
Signal Transduction and Targeted TherapyHyperuricemia is considered a modifiable risk factor for the development and progression of chronic kidney disease (CKD). There remains controversy over the effects of urate-lowering therapy (ULT) on kidney outcomes in patients with CKD and hyperuricemia.
Sheng Nie +12 more
doaj +1 more source
My migraine voice survey. aA global study of disease burden among individuals with migraine for whom preventive treatments have failed [PDF]
, 2018 Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering ...
Carboni, Veruska +14 more
core +1 more source