Results 31 to 40 of about 260,799 (302)

Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression

Pharmaceuticals, 2023
Treatment-resistant depression (TRD) is a term used to describe a particular type of major depressive disorder (MDD). There is no consensus about what defines TRD, with various studies describing between 1 and 4 failures of antidepressant therapies, with
Courtney M. Vecera, Alan C. Courtes, Gregory Jones, Jair C. Soares, Rodrigo Machado-Vieira   +4 more
doaj   +1 more source

Molecular serum signature of treatment resistant depression [PDF]

, 2016
Rationale: A substantial number of patients suffering from major depressive disorder (MDD) do not respond to multiple trials of anti-depressants, develop a chronic course of disease and become treatment resistant.
Arolt, V, Bahn, S, Chan, MK, Cooper, JD, Grosse, L, Rothermundt, M, Ruland, T, Stocki, P   +7 more
core   +1 more source

Comparing the effects of repetitive transcranial magnetic stimulation and electroconvulsive therapy in the treatment of depression : a systematic review and meta-analysis [PDF]

, 2014
Electroconvulsive therapy (ECT) is the longest standing psychiatric treatment available and has unequivocal benefit in severe depression. However this treatment comes with a number of side effects such as memory impairment.
Micallef-Trigona, Beppe
core   +4 more sources

Treatment resistant depression in women with peripartum depression

BMC Pregnancy and Childbirth, 2019
Background Peripartum depression is a leading cause of disease burden for women and yet there is little evidence as to how often peripartum depression does not respond to treatment and becomes treatment resistant depression.
M. Soledad Cepeda, David M. Kern, Susan Nicholson   +2 more
doaj   +1 more source

Treatment resistant depression in primary care: Co-constructing difficult encounters [PDF]

, 2013
Many patients with depression do not recover despite medication or therapy. Individuals with treatment resistant depression often have co-morbid anxiety, personality difficulties and drug or alcohol misuse and have been characterised as difficult ...
Byng, R, McPherson, S, Oxley, D
core   +1 more source

Effects of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation on Serum Brain-Derived Neurotrophic Factor Levels in Patients with Depression [PDF]

, 2012
Objective: Brain-derived neurotrophic factor (BDNF) levels are decreased in individuals with depression and increase following antidepressant treatment. The objective of this study is to compare pre- and post-treatment serum BDNF levels in patients with ...
Laura eGedge, Laura eGedge, Ashley eBeaudoin, Lauren eLazowski, Regina edu Toit, Ruzica eJokic, Ruzica eJokic, Roumen eMilev, Roumen eMilev   +8 more
core   +2 more sources

Rethinking treatment-resistant depression to quasi-tenacious depression

European Psychiatry, 2023
With almost one-third of patients with major depression not adequately responsive to treatments, the management of treatment-resistant depression (TRD) has continued to be challenging.
Shokouh Arjmand, Rodrigo Grassi-Oliveira, Gregers Wegener   +2 more
doaj   +1 more source

Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT randomised controlled trial [PDF]

, 2014
Background: Only one-third of patients with depression respond fully to treatment with antidepressant medication. However, there is little robust evidence to guide the management of those whose symptoms are 'treatment resistant'.<p></p> ...
Abel, Anna, Barnes, Maria, Button, Katherine, Campbell, John, Carroll, Fran, Garland, Anne, Hollinghurst, Sandra, Jerrom, Bill, Kessler, David, Kuyken, Willem, Lewis, Glyn, Metcalfe, Chris, Morrison, Jill, Odondi, Lang'o, Owen-Smith, Amanda, Peters, Tim, Ridgway, Nicola, Sherlock, Sofie, Thomas, Laura, Turner, Katrina, Turner, Nicholas, Wiles, Nicola, Williams, Chris   +22 more
core   +4 more sources

Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats [PDF]

, 2010
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells.
Asanuma, Masato, Doi, Maho, Gomita, Yutaka, Kawasaki, Hiromu, Kitamura, Yoshihisa, Matsunaga, Hisashi, Miyazaki, Ikuko, Nagamachi, Tomoko, Sendo, Toshiaki, Shinomiya, Kazuaki   +9 more
core   +1 more source

The impact of high frequency repetitive transcranial magnetic stimulation on fine motor function in medication resistant major depression [PDF]

, 2012
<b><i>Objectives:</i></b> Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been reported to improve mood symptoms in major depressive disorder (
Baeken, Chris, De Raedt, Rudi, Sabbe, Bernard GC, Schrijvers, Didier L   +3 more
core   +1 more source