Results 221 to 230 of about 212,475 (307)

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

The TPx protein of <i>Taenia solium metacestode</i> regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway. [PDF]

Front Immunol
Sun X, Mu Q, Zhou B.
europepmc   +1 more source

Muscular Treg cells [PDF]

Nature Medicine, 2014
openaire   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

The inhibition of miR-125b-5P prevented Treg differentiation through activating STAT3/HIF-1α pathway in PBMCs of ankylosing spondylitis. [PDF]

Arthritis Res Ther
Yin W, Luo B, Cheng H, Xie X, Wu F, Wang W, Zhou P, Cui X, Yu H.   +8 more
europepmc   +1 more source

Pharmacokinetics of Therapeutic Tregs

American Journal of Transplantation, 2014
openaire   +2 more sources

High‐Sensitive Mass Cytometry Metal Tags Based on Noble Metal Nanoparticles Assisting Acute Myeloid Leukemia Immune Checkpoint Profiling

Advanced Science, EarlyView.
ABSTRACT Mass cytometry is optimal for acute leukemia immune checkpoint profiling. However, current commercial metal‐chelating polymer (MCP) metal tags limit its sensitivity due to low metal loading capacity. We report a novel synthetic strategy employing antibody‐conjugated gold or platinum nanoparticles (AuNP/PtNP) for high‐dimensional single‐cell ...
Zhizhou Liu, Yu Yang, Lingfei Qiu, Yi Yang, Jingrui Li, Juan Yue, Yinghui Li, Yingdai Gao, Pengli Bai   +8 more
wiley   +1 more source

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity. [PDF]

Sci Adv
Castillo JG, Silveria S, Schirokauer L, Sauquet A, Hung J, Jaworski G, Hendricks JM, Sul HS, Olzmann JA, DuPage M.   +9 more
europepmc   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

From pathogenesis to therapy: the emerging role of regulatory T cells in amyotrophic lateral sclerosis. [PDF]

J Neuroinflammation
Zhang N, Su WM, Chen T, Zhang Q, Cao B, Wang Y, Chen YP.   +6 more
europepmc   +1 more source