Results 241 to 250 of about 215,213 (307)

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Computational analysis of multi-omics data reveals CXCL10⁺ DC-Treg interaction drives immunosuppressive microenvironment in AFP-positive hepatocellular carcinoma. [PDF]

Cell Mol Life Sci
Luo ZH, Chen WM, Yang XM, Zhao J, Zhang YL, Huang QH, Zhang MY, Wang N, Wang F, Zhou J.   +9 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Regulatory T cells in hypoxic environments. [PDF]

Front Immunol
González-Rivera L, Luna-Gutiérrez R, Cárdenas S, Merino-González C, Handy A, Pepper I, López MN.   +6 more
europepmc   +1 more source

SV2A expression in blood cells as a possible biomarker candidate for levetiracetam treatment response

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate whether synaptic vesicle protein 2A (SV2A) expression on peripheral immune cells predicts treatment response to levetiracetam in epilepsy. Methods High‐dimensional flow cytometry was used to prospectively assess SV2A expression on immune cells from levetiracetam responders, nonresponders, and ...
Johannes Lang, Mathias Linnerbauer, Jeanne Cuny, Veit Rothhammer, Hajo Hamer   +4 more
wiley   +1 more source

Role play of regulatory T cells and resolvins in type 2 diabetes. [PDF]

Front Immunol
Krishnan S, Mahadevan S, Sharma HP, Das UN, Kuppan K.   +4 more
europepmc   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells. [PDF]

Nat Metab
A M, Wang G, Zammit NW, Roth L, Maierhaba Y, Bogoslavski D, Cai C, Langston PK, Zhang Q, Afonina IS, Beyaert R, Spiegelman BM, Mathis D.   +12 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Extracellular vesicles from <i>Akkermansia muciniphila</i> protect streptozotocin-induced diabetic mice by regulating glucose homeostasis, oxidative stress, and immune tolerance. [PDF]

Front Immunol
Chang Y, Zhang C, Li Z, Wang S, Wu J, Xie J, Cheng X.   +6 more
europepmc   +1 more source