Advances in understanding the Th17/Treg balance in systemic lupus erythematosus: implications for treatment and management. [PDF]
Liu Y, Xiang L, Cheng RJ, Pan SY.
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The CTLA-4 Pathway in Human Disease: Molecular Mechanisms and Therapeutic Targeting. [PDF]
Negrini S +6 more
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The mechanisms of regulatory T cells in the immune microenvironment of multiple myeloma and clinical significance. [PDF]
Du L, Jiang Y, Zhou Q, Xu F.
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Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More? [PDF]
Knioła E +4 more
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Regulatory T cells in human pregnancy: mechanisms, dysregulation, and therapeutic perspectives. [PDF]
Liu H +5 more
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Statement of Retraction: Geniposide promotes splenic Treg differentiation to alleviate colonic inflammation and intestinal barrier injury in ulcerative colitis mice. [PDF]
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Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
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Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation.
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Differentiation of Peripheral Treg
2022This chapter shows protocols for the differentiation of peripheral Treg (pTreg) from polyclonal and monoclonal CD4+ T cells. Polyclonal naïve CD4+ T cells can differentiate into pTreg upon adoptive transfer into Foxp3-diphtheria toxin receptor transgenic recipient mice in which endogenous Tregs are transiently depleted by administration of diphtheria ...
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