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The CTLA-4 Pathway in Human Disease: Molecular Mechanisms and Therapeutic Targeting. [PDF]

open access: yesGenes (Basel)
Negrini S   +6 more
europepmc   +1 more source
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Treg and lupus

Annals of the Rheumatic Diseases, 2010
Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms.
M, Bonelli, J S, Smolen, C, Scheinecker
openaire   +2 more sources

Treg cells in atherosclerosis

Molecular Biology Reports, 2021
Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation.
Rebecca Kuan   +2 more
openaire   +2 more sources

Differentiation of Peripheral Treg

2022
This chapter shows protocols for the differentiation of peripheral Treg (pTreg) from polyclonal and monoclonal CD4+ T cells. Polyclonal naïve CD4+ T cells can differentiate into pTreg upon adoptive transfer into Foxp3-diphtheria toxin receptor transgenic recipient mice in which endogenous Tregs are transiently depleted by administration of diphtheria ...
José, Almeida-Santos   +2 more
openaire   +2 more sources

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