Results 141 to 150 of about 4,874,341 (306)
Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE2 Axis
Edouard Leveque,1,2 Régis Joulia,3 Louise Battut,2,4 Camille Laurent,1,2,5 Salvatore Valitutti,1,2,5 Nicolas Cénac,2,4 Gilles Dietrich,2,4 Eric Espinosa2,4 1Centre de Recherche en Cancérologie de Toulouse (CRCT), INSERM UMR1037, CNRS UMR5071, Toulouse, F-
Leveque E +7 more
core
Identification and Phenotype of Treg Cells
, 2013 (A) Purified CD4+ T-cells were stained with anti-CD45RO-FITC and anti-CD25-PE antibodies. The naïve, memory, and Treg subsets were identified as shown in boxes.
Stacy M Grill (69893) +6 more
core +1 more source
Advanced Science, EarlyView.A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao +9 more
wiley +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang +14 more
wiley +1 more source
PD‐1‐Enhanced Treg Cell Senescence in Advanced Maternal Age
Advanced ScienceSenescence occurs earlier in the immune system than in solid organs as age increases. Regulatory T (Treg) cells are among the first cells to exhibit signs of aging. However, whether advanced‐age pregnancy involves Treg cell aging remains unclear.
Guang‐Shun Gong +4 more
doaj +1 more source
Freeze-thaw lysates of P. falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]
, 2012 : In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to T-cell receptor stimulation with cytokine co-stimulation ...
Finney, OC +5 more
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Advanced Science, EarlyView.Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang +12 more
wiley +1 more source
Foxp1-dependent transcriptional programs in Treg cells.
, 2019 (A) Heatmap of the representative genes differentially expressed between highly purified Foxp3Cre and Foxp1f/fFoxp3Cre rTreg cells (fold change ≥1.5). (B) Enriched GO categories of the genes differentially expressed between Foxp3Cre and Foxp1f/fFoxp3Cre ...
Lei Han (150108) +10 more
core +1 more source