Results 121 to 130 of about 4,874,341 (306)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Treg cells in peribronchovascular areas.

, 2019
The numbers of Treg cells in peribronchovascular areas obtained for the Control groups after 1 (n = 8), 3 (n = 6), and 6 (n = 5) months and Smoke groups after 1 (n = 7), 3 (n = 6), and 6 (n = 10) months are presented as the means ± SDs.
Rildo Aparecido Volpini (602014), Elia Garcia Caldini (3139689), Ana Paula Pereira Velosa (3139671), Natália Gomes Gonçalves (6195602), Milton de Arruda Martins (6195614), Thais Mauad (84910), Chin Jia Lin (6195605), Mariangela Macchione (6195617), Juliana Tiyaki Ito (6195593), Juliana Dias Lourenço (6195599), Iolanda de Fátima Lopes Calvo Tibério (6195611), Gilles Landman (2137852), Daniela Aparecida de Brito Cervilha (6195596), Walcy Paganelli Rosolia Teodoro (6195608), Fernanda Degobbi Tenorio Quirino dos Santos Lopes (6195620)   +14 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Modulation of host immunity by Treg-inducing probiotics　

, 2019
Intestinal microbiota plays a critical role in the modulation of human health. Dysregulation of the commensal flora is closely linked to functional changes of the immune system and subsequently contributes to development of immune disorders.
IM, SIN HYEOG
core  

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Vitamin E and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis

Redox Biology
Background: The notable decline in the number of Tregs within Necrotizing enterocolitis (NEC) intestinal tissues，contribute to excessive inflammation and necrosis, yet the precise underlying factors remain enigmatic.
Shunchang Luo, Yingying Zeng, Baozhu Chen, Junjie Yan, Fei Ma, Guiying Zhuang, Hu Hao, Guangchao Cao, Xin Xiao, Sitao Li   +9 more
doaj   +1 more source

Adoptive transfer of Treg cells improves the protective effect of CD4⁺Foxp3^- T cells.

, 2015
(A) Survival curves of Rag1-/- mice infected with Pb18 after adoptive transfer of 2×105 Treg cells, 2×106 CD4+Foxp3- T cells, 2×105 Treg cells + 2×106 CD4+Foxp3- T cells, or vehicle only (p < 0.05 between PBS and Treg; p < 0.001 between PBS and CD4+Foxp3-
Fernando D. Pretel (335155), Flávio V. Loures (286150), Tania A. Costa (5665750), Eliseu Frank de Araújo (286151), Claudia Feriotti (286149), Silvia B. Bazan (296597), Vera L. G. Calich (286153)   +6 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Interferon Regulatory Factor 4 dose-dependently controls peripheral Treg cell differentiation and homeostasis by modulating chromatin accessibility in mice

Frontiers in Immunology
FoxP3+ regulatory T (Treg) cells restrict excessive immune responses and immunopathology as well as reactivity to self or environmental antigens and thus are crucial for peripheral immune tolerance. The transcription factor Interferon Regulatory Factor 4
Leonie Caroline Voß, Constantin Schmidt, Constantin Schmidt, Aenne Harberts, Aenne Harberts, Aenne Harberts, Michael Spohn, Michael Spohn, Michael Spohn, Peter Bradtke, Alina Borchers, Alina Borchers, Alina Borchers, Stefanie Fertig, Joanna Schmid, Friedrich Koch-Nolte, Christian F. Krebs, Christian F. Krebs, Christian F. Krebs, Friederike Raczkowski, Hans-Willi Mittrücker, Hans-Willi Mittrücker   +21 more
doaj   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source