Results 101 to 110 of about 4,874,341 (306)

Crocetin Activates Foxp3 Through TIPE2 in Asthma-Associated Treg Cells

, 2015
Background/Aims: Regulatory T cells (Treg) are critical regulators of asthma. Crocetin is isolated from Chinese herb saffron and is a natural carotenoid dicarboxylic acid with anti-inflammatory potential.
Jurong Ding, Jianhua Su, Jian Ma, Li Zhang   +3 more
core   +1 more source

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

, 2021
International audienceCD4+Foxp3+ regulatory T (Treg) cells are central modulators of autoimmune diseases. However, the timing and location of Treg cell-mediated suppression of tissue-specific autoimmunity remain undefined.
Kassem, Sahar, Lombardi, Yannis, Martin, Gaëlle, H, Grinberg-Bleyer, Yenkel, Ronin, Emilie, Pouchy, Charlotte, Sleurs, David, Lucas, Bruno, Grégoire, Sylvie, Wajant, Harald, Marodon, Gilles, Martin, Gaëlle,, Chanson, Noémie, Casrouge, Armanda, Lalle, Guilhem, Hilaire, Morgane, Salomon, Benoît, L, Auffray, Cédric, Khosravi, Maryam, Salomon, Benoît,, Sylvie Grégoire, Morgane Hilaire, Sahar Kassem, Gilles Marodon, Cédric Auffray, Benoît L. Salomon, Yenkel Grinberg-Bleyer, Armanda Casrouge, Noémie Chanson, Maryam Khosravi, Charlotte Pouchy, Harald Wajant, Yannis Lombardi, David Sleurs, Bruno Lucas, Gaëlle H. Martin, Guilhem Lalle, Emilie Ronin   +37 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

New insights into Regulatory T cells：exosome and non-coding RNA mediated regulation of homeostasis, and resident regulatory T cells

Frontiers in Immunology, 2016
Regulatory T (Treg) cells are a population of cells that are heterogeneous in origin and in functional activity. Treg cells constitute an essential counterbalance to adaptive immune responses.
Peiyao Li, Peiyao Li, Peiyao Li, Changhong Liu, Changhong Liu, Changhong Liu, Zhibin Yu, Zhibin Yu, Zhibin Yu, Minghua Wu, Minghua Wu, Minghua Wu   +11 more
doaj   +1 more source

Effect of rapamycin on Treg cells.

, 2013
Representative dot plot of flow cytometry analysis of draining lymph nodes for percent of Treg (CD4+CD25+FoxP3+) in CD4+ (A) and in CD4+CD44high (B) in controls and rapamycin (3 mg/kg/day) treated mice. Percent of Treg (CD4+CD25+FoxP3+) in CD4+ (A, right)
Yves Allenbach (483114), Nicolas Prevel (483113), David Klatzmann (314753), Benoit Salomon (483115), Olivier Benveniste (483116)   +4 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

NKG2D+CD4+ T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus

Scientific Reports, 2017
Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T ...
Di Yang, Zhiqiang Tian, Mengjie Zhang, Weibing Yang, Jun Tang, Yuzhang Wu, Bing Ni   +6 more
doaj   +1 more source

Beta-2 adrenergic receptors increase TREG cell suppression in an OVA-induced allergic asthma mouse model when mice are moderate aerobically exercised

BMC Immunology, 2018
Background The potency of T regulatory (TREG) cells to inhibit T helper (Th)-driven immune cell responses has been linked to increased intracellular cyclic-AMP (cAMP) levels of TREG cells.
Kari J. Dugger, Taylor Chrisman, Sarah L. Sayner, Parker Chastain, Kacie Watson, Robert Estes   +5 more
doaj   +1 more source

Non-coding RNA and transcriptional regulation in CD4 T cell lineages [PDF]

, 2015
CD4 T cell lineage choice epitomises the ability of the immune system to become tailored to a specific threat and provides a framework for understanding the mechanisms behind cell specification.
Evans, CM
core