Results 91 to 100 of about 4,874,341 (306)
, 2013 A. Platelet count of CR patients at diagnosis, 1month after the initial of treatment, 2 months and 12 months after diagnosis. B. Platelet count of NR patients at diagnosis, 1month after the initial of treatment, 2 months and 12 months after diagnosis. C.
Feng Li (30515) +9 more
core +1 more source
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
MHC Class II-Peptide Complexes Displayed on Activated T Cells Guide Treg Suppression
, 2017 Background: Regulatory T cell (Treg) therapy remains a promising strategy for minimizing immunosuppression and extending allograft survival. Treg suppression requires initial activation through Treg-target cell contacts and T cell receptor (TCR ...
Fryer, Madeline Louise
core +5 more sources
Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity
Cell Reports, 2017 Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study,
Byung-Seok Kim +14 more
doaj +1 more source
Suppressive capacity of Treg cells treated with dendrimers.
, 2016 Mean + SEM of the percentage of CD69 and CD154 activation markers in stimulated allogeneic PBMC alone (PBM ST) and co-cultured with Treg cells treated or non-treated (Treg NT) with cationic or anionic dendrimers (Treg: PBMC ratio of 1:1). Treg NT (n = 5),
Didiana Jaramillo-Ruiz (846629) +4 more
core +1 more source
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo
, 2020 © Fernandes et al. T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet the degree of peptide specificity of Treg-cell function, and whether Treg ...
Mathis, Diane +25 more
core +1 more source
Advanced Science, EarlyView.Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley +1 more source
Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
New Paradigm in the Role of Regulatory T Cells During Pregnancy
Frontiers in Immunology, 2019 Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal tolerance induced by CD4+CD25+FoxP3+ regulatory T (Treg) cells is established during pregnancy.
Sayaka Tsuda +3 more
doaj +1 more source