Results 101 to 110 of about 130,982 (298)

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity

Cancer Management and Research, 2020
Yaling Li,1– 3 Junjie Li,1 Juanjuan Dong,1 Lei Zhang,2 Dongling Liu,1,4 Jianzheng He,1– 3 Yali She,2 Chengxu Ma,2 Yongqi Liu1– 3 1Provincial-Level Key Laboratory of Molecular Medicine of Major Diseases and Study on Prevention and ...
Li Y, Li J, Dong J, Zhang L, Liu D, He J, She Y, Ma C, Liu Y   +8 more
doaj  

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Beyond the immune suppression: the immunotherapy in prostate cancer [PDF]

, 2015
Prostate cancer (PCa) is the second most common cancer in men.Aswell in many other human cancers, inflammation and immune suppression have an important role in their development.We briefly describe the host components that interact with the tumor to ...
Agliano', Anna Maria, Cattarino, Susanna, Collalti, Giulia, Sciarra, Alessandro, Silvestri, Ida   +4 more
core   +3 more sources

Inorganic Nanomaterials Meet the Immune System: An Intricate Balance

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
Metal nanomaterials influence the immune responses, such as cytokine production and T‐cell activity. Unintended immune modulation can have significant consequences while its fine‐tuning may transform the oncology care. Within this review, a critical analysis is offered regarding the nano/immune‐interaction and suggests the future research directions to
Gloria Pizzoli, Marco Gargaro, Giuliana Drava, Valerio Voliani   +3 more
wiley   +1 more source

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Engineered Hybrid Treg-Targeted Nanosomes Restrain Lung Immunosuppression by Inducing Intratumoral CD8+T Cell Immunity

International Journal of Nanomedicine, 2022
Kalliopi Domvri,1 Savvas Petanidis,2,3 Paul Zarogoulidis,4 Doxakis Anestakis,5 Charalampos Charalampidis,5 Drosos Tsavlis,6 Haidong Huang,7 Lutz Freitag,8 Wolfgang Hohenforst-Schmidt,9 Dimitris Matthaios,10 Theodora Katopodi,2 Konstantinos Porpodis3 ...
Domvri K, Petanidis S, Zarogoulidis P, Anestakis D, Charalampidis C, Tsavlis D, Huang H, Freitag L, Hohenforst-Schmidt W, Matthaios D, Katopodi T, Porpodis K   +11 more
doaj  

HGF/c‐Met Axis‐Targeted Nanotherapy via GSH‐Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis

Advanced Healthcare Materials, EarlyView.
To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao, Hanhan Liu, Hanchen Zhang, Hong Ren, Binyu Wen, Jing Zhang, Jiaqi Du, Ziyi Cai, Zhihong Deng   +8 more
wiley   +1 more source

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source