Results 81 to 90 of about 124,395 (259)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Comprehensive Explorations of CCL28 in Lung Adenocarcinoma Immunotherapy and Experimental Validation

Journal of Inflammation Research, 2023
Xiangyu Su,1,2 Guoqing Wang,3 Shiya Zheng,2 Chang Ge,4 Fei Kong,4 Cailian Wang1,2 1School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Department of Oncology, Zhongda Hospital, School of Medicine, Southeast University,
Su X, Wang G, Zheng S, Ge C, Kong F, Wang C   +5 more
doaj  

CCR9 is preferentially expressed by Tregs.

, 2015
CCR9 is preferentially expressed by Tregs.
Feidi Chen (778507), Han Liu (288039), Chong He (676805), Maria G. Gonzalez (778508), Suxia Yao (685815), Wei Wu (27708), Anthony T. Cao (778506), Yingzi Cong (325439), Sara M. Dann (778509), Heather L. Evans-Marin (778505)   +9 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

The gating strategies for identifying FOXP3+ Tregs (panel 8).

, 2019
For panel 8, the strategies of the first to fifth gates were the same as in panels 5 and 6 (Figs 4B and 5A). After gating on CD3+CD4+ T cells (G6), FOXP3 vs CD127 was used to assess the proportions of CD4+FOXP3- effector cells (G7), CD4+FOXP3+Tregs (G8 ...
Hsiao-Ting Chen (6725804), Negar Talaei Zanjani (6725813), Heather Burns (6725798), Suat Dervish (6725816), Yi Vee Chew (6725792), Ellis Patrick (4219258), Philip J. O’Connell (6725825), Xin Maggie Wang (6725819), Karen Keung (6725810), Wayne Hawthorne (6725822), Patricia Anderson (6725801), Lindy Williams (6725807), Elvira Jimenez Vera (6725789), Stephen Alexander (452429), Shounan Yi (510456), Min Hu (41912), Leigh Nicholson (6725795)   +16 more
core   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases

Frontiers in Immunology, 2020
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells.
Dan-Yang Li, Dan-Yang Li, Xian-Zhi Xiong, Xian-Zhi Xiong   +3 more
doaj   +1 more source

Differential Protein Synthesis Rates in Tregs, conventional T cells, and ex-Tregs following LPS Stimulation 2332109

Introduction Protein synthesis is a metabolically demanding process that differs among T cell subsets based on their functional states and suppressive capacity.
Hayden Harach, Alexandra Staiculescu, Gabriela Ladino, Arit Ghosh   +3 more
core   +1 more source

FoxP3+ Tregs infiltration meta-analysis.

, 2023
Influence of NAC in the FoxP3+ Tregs infiltration of BC tumors. Forest plot for the different outcomes regarding FoxP3+ Tregs infiltration before and after NAC.
María Alejandra Villota-Álava (15368651), Nicolás Lalinde-Ruíz (15368648), Ivon Johanna Rodríguez-Rodríguez (15368654), Laura Camila Martínez-Enriquez (15368639), Carlos Alberto Parra-López (14599806), Esteban Alejandro Velandia-Vargas (15368645), María del Pilar Montilla-Velásquez (15368657), Manuela Llano-León (14599800), Oscar Mauricio Rodríguez-Bohórquez (15368642)   +8 more
core   +1 more source