Results 101 to 110 of about 111,477 (307)

In vivo treatment with entinostat decreases Foxp3 expression in Tregs and inhibits Tregs function.

, 2012
BALB/c mice were treated with vehicle (0.5% methocel) or 5 mg/kg/day or 20 mg/kg/day of entinostat by gavage for 5 days. Cells were harvested from spleens and lymph nodes.
Michael Ciesielski (186052), Paula Sotomayor (186059), Leigh Ellis (186058), Kiersten M. Miles (186056), Roberto Pili (186063), Swathi Ramakrishnan (186054), Li Shen (110858), Protul Shrikant (186061), Robert Fenstermaker (186062)   +8 more
core   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Blockade of IL-27 signaling ameliorates herpes stromal keratitis with upregulated CD4+ Foxp3+ regulatory T cells influx in mice

Indian Journal of Ophthalmology, 2019
Purpose: The purpose of this study was to investigate the production of IL-27 p28 and EBI3 in the ocular inflammatory sites, and the role of IL-27 signaling in a model of HSV-1 induced herpetic stromal keratitis (HSK).
Likun Xia, Tianchang Tan, Yang Li, Qiuyue Zhong, Mei Shi   +4 more
doaj   +1 more source

Co-inhibitory immune signaling generates the splicing of an immunophilin which marks a Tregs subset associated with immunotherapy response of melanoma patients

, 2018
Cancer immunotherapy has shown surprising efficacy in several types of advanced and incurable tumors, particularly, malignant melanoma. There are several immunotherapeutic strategies aimed at enhancing immunological defenses against tumor.
Romano MF
core  

Frequency of CD4 Tregs in HIV-infected individuals.

, 2022
The frequency of Tregs (CD25+ CD127- FoxP3+) within the memory pool of CD4 Tregs evaluated in PBMC from viremic and ART-suppressed individuals. Lines designate means. (TIFF)
Vincent C. Marconi (8232468), Andrew R. Rahmberg (13141289), Kevin Nguyen (287872), Deanna A. Kulpa (7495796), Jason M. Brenchley (8704194), Steven E. Bosinger (8777792), Gregory K. Tharp (5684063), Mirko Paiardini (243070), Lavinia Franchitti (5206430), Justin L. Harper (7517858), Zhan Zhang (215106), Eli A. Boritz (10573403), Zachary Strongin (13141283), Max Lee (9691568), Timothy N. Hoang (13141286), Barbara Cervasi (243064), Guido Silvestri (94156)   +16 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

MDS-MSC induce CD4+CD25+Foxp3+Tregs.

, 2013
(A) CD4+CD25-T cells were cultured with MDS-MSC or normal-MSC for 5 days, and CD4+ T cells were collected. The expression of CD25 and Foxp3 on CD4+ T cells was analyzed by FACS.
Qiubai Li (306378), Yong You (28100), Zhenling Wang (306377), Ping Zou (35236), Weiming Li (126966), Zhigang Zhao (288127)   +5 more
core   +1 more source

Tregs in Immunotherapy: Opportunities and Challenges [PDF]

Immunotherapy, 2011
n ...
openaire   +3 more sources

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source