Results 111 to 120 of about 120,068 (304)

MDS-MSC induce CD4+CD25+Foxp3+Tregs.

, 2013
(A) CD4+CD25-T cells were cultured with MDS-MSC or normal-MSC for 5 days, and CD4+ T cells were collected. The expression of CD25 and Foxp3 on CD4+ T cells was analyzed by FACS.
Qiubai Li (306378), Yong You (28100), Zhenling Wang (306377), Ping Zou (35236), Weiming Li (126966), Zhigang Zhao (288127)   +5 more
core   +1 more source

Suppressive and immunoprotective functions of Tregs [PDF]

, 2011
CD4+CD25+Foxp3+ T lymphocytes, known as regulatory T cells or Tregs, have been proposed to be a lineage of professional immune suppressive cells that exclusively counteract the effects of the immunoprotective "helper" and "cytotoxic" ...
Lixin Zheng, Michael eLenardo, Michael J. Lenardo, Lixin eZheng, Pushpa ePandiyan, Pushpa Pandiyan   +5 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)

Медицинская иммунология, 2018
Memory T cells are necessary for development of the immune response and represent one of the most numerous population of human T lymphocytes. On the contrary, suppressive regulatory T cells (Tregs) may terminate the immune response and help to maintain ...
E. K. Oleinik, A. V. Churov, V. M. Oleinik   +2 more
doaj   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

CD45 ligation expands Tregs by promoting interactions with DCs [PDF]

, 2014
Regulatory T cells (Tregs), which express CD4 and FOXP3, are critical for modulating the immune response and promoting immune tolerance. Consequently, methods to expand Tregs for therapeutic use are of great interest.
Fadi G. Lakkis, Finn, Patricia W., Lakkis, Fadi G., Wang, Ying, Geoffrey Camirand, Guz, Galip, Yuning Lu, Donna L. Farber, Songyan Deng, Rudd, Christopher E., Lu, Yuning, Rothstein, David M., Flavell, Richard A., Perkins, David L., Wan, Yisong Y., Deng, Songyan, Yisong Y. Wan, Warren D. Shlomchik, Camirand, Geoffrey, Galip Guz, David M. Rothstein, Richard A. Flavell, Christopher E. Rudd, Shlomchik, Warren D., David L. Perkins, Ying Wang, Farber, Donna L., Yan Lin, Lin, Yan, Patricia W. Finn   +29 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Lymphocyte metabolism and the level of circulatory cytokines in children with autoimmune disease

Медицинская иммунология
In recent decades, there has been an increase in the incidence of autoimmune diseases (AID) among adults and children. The immunopathogenesis of AID is based on an imbalance between autoaggressive and regulatory cells (Tregs), which is regulated by ...
T. V. Radygina, O. V. Kurbatova, D. G. Kuptsova, S. V. Petrichuk, A. P. Fisenko, G. B. Movsisyan, L. M. Abdullaeva, A. S. Potapov, N. N. Murashkin, D. V. Parakhina   +9 more
doaj   +1 more source

Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis

Autoimmunity, 2017
Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur, Rama Krishna Gurram, Sudeep K. Maurya, Sajid Nadeem, Sathi Babu Chodisetti, Nargis Khan, Javed Naim Agrewala   +6 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source