Results 131 to 140 of about 111,477 (307)

Cytokine Couture: Designer IL2 Molecules for the Treatment of Disease

ImmunoTargets and Therapy
Amy Dashwood,1,2 Arman Ali Ghodsinia,1 James Dooley,1 Adrian Liston1 1Department of Pathology, University of Cambridge, Cambridge, UK; 2Immunology Programme, Babraham Institute, Cambridge, UKCorrespondence: Amy Dashwood; Email ajd241@cam.ac.uk Adrian ...
Dashwood A, Ghodsinia AA, Dooley J, Liston A   +3 more
doaj  

Helios expression in Tregs in different ages.

, 2013
Helios expression in Tregs in different ages.
Ulf H. Beier (188290), Tatiana Akimova (345316), Matthew H. Levine (345319), Wayne W. Hancock (44791), Liqing Wang (188282)   +4 more
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Suppressive and immunoprotective functions of Tregs

, 2011
CD4+CD25+Foxp3+ T lymphocytes, known as regulatory T cells or Tregs, have been proposed to be a lineage of professional immune suppressive cells that exclusively counteract the effects of the immunoprotective "helper" and "cytotoxic" ...
Lixin Zheng, Michael eLenardo, Michael J. Lenardo, Lixin eZheng, Pushpa ePandiyan, Pushpa Pandiyan   +5 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Third party approach using cord blood Tregs in allo-transplantation [PDF]

, 2010
Compelling data has demonstrated the fundamental role of regulatory T cells (Tregs) in immuno-regulation. In vivo animal models indicate that recipient’s CD4pos CD25pos T cells adoptively transferred can prevent or control graft versus host disease ...
Figueroa Tentori, D.
core  

Targeting tumor-infiltrating tregs for improved antitumor responses [PDF]

Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells (Tregs), as crucial components of the tumor immune environment, has great therapeutic potential.
Xiaoyu Li, Yugu Zhang, Pei Shu, Diyuan Qin, Yongsheng Wang, Yanna Lei   +5 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Application Potential of the Regulation of Tregs Function by Irisin in the Prevention and Treatment of Immune-Related Diseases

Zhengjiang Wang,1,2,* Jiaqi Xu,1,2,* Liqun Mo,1 Renshu Zhan,1,2 Jin Zhang,3 Li Liu,1,2 Jun Jiang,4 Yingying Zhang,1,2 Yiping Bai1,2 1Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province ...
Jiang J, Liu L, Zhang J, Zhan R, Zhang Y, Mo L, Bai Y, Wang Z, Xu J   +8 more
core  

Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance

CD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in tolerance are poorly understood.
Brian S. Gloss, Natasha M. Rogers, Geoff Y. Zhang, Yuan Min Wang, Guoping Zheng, Min Hu, Shounan Yi, Wayne J. Hawthorne, Hannah Wang, Yuanfei Zhao, Leigh Nicholson, Joey Lai, Heather Burns, Philip J. O’Connell, Yi Vee Chew, Adwin Thomas, Stephen I. Alexander, Elvira Jimenez-Vera, Yi Wen Qian   +18 more
core   +1 more source