Results 71 to 80 of about 111,477 (307)

Curcumin modulates inflammatory responses in peripheral blood mononuclear cells from women with gestational diabetes mellitus

Central European Journal of Immunology
Introduction Curcumin is a multi-functional component with anti-inflammatory and immunomodulatory properties. Unregulated immune responses may be a causative factor in the development of gestational diabetes mellitus (GDM).
Zhenzhen Liu, Liu Zheng, Yao Wu, Huijuan Li, Junfang Liu   +4 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

The phenotype of hepatic Tregs.

, 2015
HMNCs were isolated from mice consuming normal diet (ND) or low concentration of n-3 PUFA-enriched diet (L-PUFA). The expression of CD62L, CD103 and CTLA-4 on hepatic Tregs (CD4+CD25+Foxp3+) was analyzed by flow cytometry.
Wenjing Luo (325831), Min Lian (36697), Zhiping Li (95072), Yongheng Sui (492280), Jing Hua (198347)   +4 more
core   +1 more source

TLRs toll for Tregs [PDF]

Journal of Leukocyte Biology, 2019
Abstract Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy.
openaire   +3 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

A strategy to purify, expand and gene-mark regulatory T cells (tregs) for use in the treatment of chronic Graft-Versus-Host Disease (GVHD)

, 2019
Background & Aim Chronic Graft-Versus-Host Disease (GVHD) is a major complication of bone marrow transplantation. Regulatory T cells (Tregs) have been shown to ameliorate GVHD in pre-clinical studies and early phase clinical trials.
Mudie, K, Au, R, Hill, G, Kennedy, G, Ping, Z, Tey, S, Hutchins, C, Western, R   +7 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Kinetics of spleen-derived Tregs.

, 2014
The Treg population is increased after experimental myocardial infarction. (A) FACS assay of Tregs after myocardial infarction shows the numbers of Tregs, expressed as a percentage of the total number of CD4 cells, 1 day, 5 days, 14 days and 30 days ...
Michal Entin–Meer (667479), Aviv Shaish (667478), Rinat Sharir (667475), Tamar Ben-Mordechai (667476), Gad Keren (376640), Jonathan Semo (618057), Sara Shimoni (580575), Jacob George (205614), Sofia Maysel-Auslender (376638), Natalie Landa-Rouben (667477)   +9 more
core   +1 more source

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

PLoS ONE, 2008
Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation. For clinical trials, it is essential to have a clinical grade Treg isolation protocol in accordance with Good Manufacturing Practice (GMP) guidelines.
Peters, J.H., Preijers, F.W.M.B., Woestenenk, R.M., Hilbrands, L.B., Koenen, H.J.P.M., Joosten, I.   +5 more
openaire   +5 more sources

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg [PDF]

Frontiers in Immunology, 2018
We conducted an experimental database analysis to determine the expression of 61 CD4+ Th subset regulators in human and murine tissues, cells, and in T-regulatory cells (Treg) in physiological and pathological conditions. We made the following significant findings: (1) adipose tissues of diabetic patients with insulin resistance upregulated various Th ...
Keman Xu, Keman Xu, William Y. Yang, William Y. Yang, Gayani Kanchana Nanayakkara, Gayani Kanchana Nanayakkara, Ying Shao, Ying Shao, Fan Yang, Wenhui Hu, Wenhui Hu, Eric T. Choi, Eric T. Choi, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +17 more
openaire   +3 more sources