Results 51 to 60 of about 111,477 (307)

Pathological conditions re-shape physiological Tregs into pathological Tregs [PDF]

Burns & Trauma, 2015
AbstractCD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in
Yang, William Y, Shao, Ying, Lopez-Pastrana, Jahaira, Mai, Jietang, Wang, Hong, Yang, Xiao-feng   +5 more
openaire   +2 more sources

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source

Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model

Pharmaceutical Biology, 2021
Context Cryptotanshinone (CT), a lipophilic compound extracted from roots of Salvia miltiorrhiza Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis.
Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan, Weixin Zhu   +6 more
doaj   +1 more source

In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice.

, 2009
BACKGROUND: Regulatory T cells (Tregs) were shown to be central in maintaining immunological homeostasis and preventing the development of autoimmune diseases.
Avidan U Neumann, Heidy Zinger, Amir Sharabi, Edna Mozes, Avidan U. Neumann, Arnon Arazi   +5 more
core   +1 more source

Th17/Treg Imbalance and Atherosclerosis [PDF]

Disease Markers, 2020
Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity.
Xin He, Bo Liang, Ning Gu
openaire   +2 more sources

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

OncoImmunology, 2018
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations.
Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J. Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos   +10 more
doaj   +1 more source

Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells

Frontiers in Immunology, 2019
Th9 cells orchestrate allergic lung inflammation by promoting recruitment and activation of eosinophils and mast cells, and by stimulating epithelial mucus production, which is known to be mainly dependent on IL-9.
Raquel de Souza Vieira, Angela Castoldi, Paulo José Basso, Meire Ioshie Hiyane, Niels Olsen Saraiva Câmara, Niels Olsen Saraiva Câmara, Niels Olsen Saraiva Câmara, Rafael Ribeiro Almeida, Rafael Ribeiro Almeida   +8 more
doaj   +1 more source

Polymeric nanoparticles containing rapamycin and autoantigen induce antigen-specific immunological tolerance for preventing vitiligo in mice

Human Vaccines & Immunotherapeutics, 2021
Vitiligo is an autoimmune disease in which pigment is lost in patches of the skin. CD4+ T cells are implicated in vitiligo while regulatory T cells (Tregs) could ameliorate vitiligo.
Xia Zhang, Daji Liu, Minghong He, Mao Lin, Caixia Tu, Baoxiang Zhang   +5 more
doaj   +1 more source

Kinase signaling network specificities of human Tregs.

, 2012
Comparative kinome analysis revealed differential kinase expression in Tregs and Teffs. Altered kinase expression in Tregs (RF = Treg/Teff) is indicated by green (increased expression in Tregs) and red boxes (reduced expression in Tregs).
Tobias Reinl (150919), Jochen Huehn (8746), Sebastian König (150917), Michael Probst-Kepper (23722), Lothar Jänsch (28449), Burkhart Schraven (34080), Andreas Jeron (23721)   +6 more
core   +1 more source