Results 51 to 60 of about 120,068 (304)
Pathological conditions re-shape physiological Tregs into pathological Tregs [PDF]
Burns & Trauma, 2015 AbstractCD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in
Yang, William Y +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
OncoImmunology, 2018 D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations.
Martin Böttcher +10 more
doaj +1 more source
Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells
Frontiers in Immunology, 2019 Th9 cells orchestrate allergic lung inflammation by promoting recruitment and activation of eosinophils and mast cells, and by stimulating epithelial mucus production, which is known to be mainly dependent on IL-9.
Raquel de Souza Vieira +8 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Vitiligo is an autoimmune disease in which pigment is lost in patches of the skin. CD4+ T cells are implicated in vitiligo while regulatory T cells (Tregs) could ameliorate vitiligo.
Xia Zhang +5 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer [PDF]
Iranian Journal of Colorectal Research, 2016 Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which ...
Zahra Mojtahedi +2 more
doaj
Медицинская иммунология, 2023 Tumors are a leading pathology in the population. Chemotherapy cannot provide adequately and effectively to cure patients. Some medicine, such as cytostatic, are characterized by a wide range of side effects and resistance of solid tumors to chemotherapy
A. A. Aktanova +5 more
doaj +1 more source
The Fate of Human Treg Cells [PDF]
Immunity, 2009 In this issue of Immunity, Miyara et al. (2009) demonstrate that FoxP3(+) cells in human peripheral blood are heterogeneous in function, and CD45RA expression defines their different stages of differentiation.
BATTAGLIA, MARCO MARIA +1 more
openaire +3 more sources
Kinase signaling network specificities of human Tregs.
, 2012 Comparative kinome analysis revealed differential kinase expression in Tregs and Teffs. Altered kinase expression in Tregs (RF = Treg/Teff) is indicated by green (increased expression in Tregs) and red boxes (reduced expression in Tregs).
Tobias Reinl (150919) +6 more
core +1 more source