Results 61 to 70 of about 111,477 (307)
Deficiency of Tregs in hypertension‐associated left ventricular hypertrophy
, 2023 Left ventricular hypertrophy (LVH) is the most common target organ damage in hypertension. Abnormal numbers or functions of CD4+CD25+Foxp3+ regulatory T lymphocytes (Tregs) can cause immune disorders, which participates in LVH.
Li Shen +3 more
core +1 more source
The Fate of Human Treg Cells [PDF]
Immunity, 2009 In this issue of Immunity, Miyara et al. (2009) demonstrate that FoxP3(+) cells in human peripheral blood are heterogeneous in function, and CD45RA expression defines their different stages of differentiation.
BATTAGLIA, MARCO MARIA +1 more
openaire +3 more sources
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer [PDF]
Iranian Journal of Colorectal Research, 2016 Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which ...
Zahra Mojtahedi +2 more
doaj
Медицинская иммунология, 2023 Tumors are a leading pathology in the population. Chemotherapy cannot provide adequately and effectively to cure patients. Some medicine, such as cytostatic, are characterized by a wide range of side effects and resistance of solid tumors to chemotherapy
A. A. Aktanova +5 more
doaj +1 more source
The frequency of Tregs, the frequency of Th17 cells, and Tregs/Th17 ratio are correlated with RAI.
, 2014 To confirm whether Tregs, Th17 cells and Tregs/Th17 were associated with the liver allograft rejection, we analyzed the correlation between RAI and the frequency of circulating Tregs, the frequency of circulating Th17 cells, and Tregs/Th17 ratio.
Fu-Sheng Wang (300650) +9 more
core +1 more source
Treg cells to the rescue [PDF]
Arthritis & Rheumatism, 2012 In this issue of Arthritis & Rheumatism, Kong and colleagues report that collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), can be effectively treated by systemic injection of Treg cells (1). These results raise several questions: Are there defects in Treg cell numbers or function in RA?
openaire +3 more sources
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
Suppressive function of expanded Tregs.
, 2014 A. Suppressive activity of expanded Tregs from HIV-1+ (n = 7 controllers +11 chronic untreated individuals) and healthy controls (n = 4) on activated CD8+ T cells (left) and CD4+ T cells (right).
Melanie King (519982) +12 more
core +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source