Results 61 to 70 of about 120,068 (304)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Suppressive function of expanded Tregs.
, 2014 A. Suppressive activity of expanded Tregs from HIV-1+ (n = 7 controllers +11 chronic untreated individuals) and healthy controls (n = 4) on activated CD8+ T cells (left) and CD4+ T cells (right).
Melanie King (519982) +12 more
core +1 more source
Gate strategy analysis of Tregs.
, 2022 Dot/contour plots are representative of the analysis strategy used. First the gate of lymphocytes (SSC-A x FSC-A) was delimited, and from it the gate for single cells (FSC-H x FSC-A) was made. From the resulted population CD3+ followed by CD4+, and CD25+
Marcela Helena Gonçalves-Pereira (12488285) +7 more
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Central European Journal of ImmunologyIntroduction Curcumin is a multi-functional component with anti-inflammatory and immunomodulatory properties. Unregulated immune responses may be a causative factor in the development of gestational diabetes mellitus (GDM).
Zhenzhen Liu +4 more
doaj +1 more source
Journal of Leukocyte Biology, 2019 Abstract Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy.
openaire +3 more sources
The frequency of Tregs, the frequency of Th17 cells, and Tregs/Th17 ratio are correlated with RAI.
, 2014 To confirm whether Tregs, Th17 cells and Tregs/Th17 were associated with the liver allograft rejection, we analyzed the correlation between RAI and the frequency of circulating Tregs, the frequency of circulating Th17 cells, and Tregs/Th17 ratio.
Fu-Sheng Wang (300650) +9 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Advanced Functional Materials, EarlyView.Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang +16 more
wiley +1 more source
Kinetics of spleen-derived Tregs.
, 2014 The Treg population is increased after experimental myocardial infarction. (A) FACS assay of Tregs after myocardial infarction shows the numbers of Tregs, expressed as a percentage of the total number of CD4 cells, 1 day, 5 days, 14 days and 30 days ...
Michal Entin–Meer (667479) +9 more
core +1 more source