Results 41 to 50 of about 111,477 (307)
Tregs and transplantation tolerance [PDF]
Journal of Clinical Investigation, 2004 The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh +2 more
openaire +4 more sources
Tumor inflating lymphocytes. Purification, expanding and cytotoxicity analisys on primary tumor cultures [PDF]
Клиническая практика, 2020 Background. Tumor Infiltrating Lymphocytes (TILs) is one of the most promising sources of autologous cytotoxic T-cells for adoptive immunotherapy, which has already shown high efficiency in the treatment of metastatic melanoma.
G. M. Yusubalieva +13 more
doaj +1 more source
GPx1−/− Tregs were hyperfunctional than WT Tregs.
, 2014 (A) A representative panel of FACS plots for the analysis of suppressive function of Tregs from GPx1−/− mice. On the 3rd day of culture, live CD4+ cells were gated for analysis.
Anbok Lee (532405) +8 more
core +1 more source
Epigenetics, 2018 IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to various stimuli and is constitutive in regulatory T cells (Tregs).
Marie-Pierre Belot +3 more
doaj +1 more source
Ncf1−/− Tregs were hypofunctional than WT Tregs.
, 2014 (A) A representative panel of FACS plots for the analysis of suppressive function of Tregs from Ncf1−/− mice. On the 3rd day of culture, live CD4+ cells were gated for analysis.
Anbok Lee (532405) +8 more
core +1 more source
Oncotarget, 2015 FOXP3 positive regulatory T cells (Tregs) are key players in maintaining peripheral immune tolerance. Multiple molecules and signaling pathways are involved in regulating Treg function. Understanding these mechanisms is vital to designing Treg-targeted immunotherapeutic strategies for cancer and other diseases. A recent study uncovered that endoplasmic
Yongliang, Zhang +2 more
openaire +2 more sources
KO Tregs were hyperfunctional.
, 2014 CFSE-labeled Teffs were stimulated in the presence of DCs and Tregs from WT or KO mice. On the 3rd day, the cells were harvested and stained for surface CD4.
Anbok Lee (532405) +7 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Gate strategy analysis of Tregs.
, 2022 Dot/contour plots are representative of the analysis strategy used. First the gate of lymphocytes (SSC-A x FSC-A) was delimited, and from it the gate for single cells (FSC-H x FSC-A) was made. From the resulted population CD3+ followed by CD4+, and CD25+
Marcela Helena Gonçalves-Pereira (12488285) +7 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source