Results 21 to 30 of about 124,395 (259)

Diminished Pneumococcal-Specific CD4+ T-Cell Response is Associated With Increased Regulatory T Cells at Older Age

Frontiers in Aging, 2021
Respiratory infection caused by Streptococcus pneumoniae is a leading cause of morbidity and mortality in older adults. Acquired CD4+ T cell mechanism are essential for the protection against colonization and subsequent development of infections by S ...
Samantha W. J. He, Martijn D. B. van de Garde, Daan K. J. Pieren, Martien C. M. Poelen, Franziska Voß, Mohammed R. Abdullah, Sven Hammerschmidt, Cécile A. C. M. van Els   +7 more
doaj   +1 more source

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs [PDF]

, 2023
FOXP3(+) regulatory T cells (Tregs) are central for peripheral tolerance, and their deregulation is associated with autoimmunity. Dysfunctional autoimmune Tregs display pro-inflammatory features and altered mitochondrial metabolism, but contributing ...
Schroeder, Agnes, Van Zeebroeck, Lauren, van Gisbergen, Marike W, Yoset, Nir, Schröder, A., Haase, Stefanie, Geisberger, Sabrina, Wagner, Allon, Côrte-Real, Beatriz F, Roels, Joris, van Gisbergen, Marike W., Yosef, N., Mueller, Dominik N., Brenner, Dirk, van Gisbergen, Marike W.; id_orcid, Hafler, David A., Arroyo Hornero, R., Dubois, L.J., Wagner, A., Hamad, I., Krampert, Luka, Dubois, Ludwig J., Linker, R.A., Côrte-Real, B.F., Kurniawan, H., Hellings, Niels, Weiss, Susanne N Y, van Gisbergen, M.W., Van Zeebroeck, L., Jantsch, Jonathan, Bartolomaeus, Hendrik, Müller, Dominik N., Weiss, Susanne N. Y., Jantsch, J., Saeys, Yvan, Geisberger, S., Schmetterer, Klaus G, Weiss, Susanne N.Y., Dyczko, A., Stegbauer, Johannes, Saeys, Y., Kurniawan, Henry, Schmetterer, K.G., Hellings, N., Linker, Ralf A, Müller, D.N., Côrte-Real, Beatriz F., Haase, S., Schröder, Agnes, Linker, Ralf A., Brenner, D., Roels, J., Dubois, Ludwig J, Yosef, Nir, Hafler, D.A., Arroyo Hornero, Rebeca, Schmetterer, Klaus G., Kleinewietfeld, Markus, FERNANDES CORTE-REAL, Beatriz, Kempa, S., Stegbauer, J., Dyczko, Aleksandra, Bartolomaeus, H., Hafler, David A, Weiss, S.N.Y., Krampert, L., Kleinewietfeld, M., Hamad, Ibrahim, Müller, Dominik N, Kempa, Stefan, Sabrina Geisberger, Beatriz F. Côrte-Real, Henry Kurniawan, Ibrahim Hamad, David A. Hafler, Stefan Kempa, Yvan Saeys, Agnes Schröder, Aleksandra Dyczko, Lauren Van Zeebroeck, Ralf A. Linker, Dirk Brenner, Dominik N. Müller, Allon Wagner, Ludwig J. Dubois, Nir Yosef, Rebeca Arroyo Hornero, Johannes Stegbauer, Marike W. van Gisbergen, Jonathan Jantsch, Markus Kleinewietfeld, Joris Roels, Luka Krampert, Hendrik Bartolomaeus, Klaus G. Schmetterer, Stefanie Haase, Niels Hellings, Susanne N.Y. Weiss   +97 more
core   +1 more source

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

OncoImmunology, 2022
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood   +21 more
doaj   +1 more source

In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System

Frontiers in Cell and Developmental Biology, 2021
Sickle Cell Disease (SCD) is an autosomal recessive disorder resulting from a β-globin gene missense mutation and is among the most prevalent severe monogenic disorders worldwide.
Alba Saenz de Villaverde Cortabarria, Laura Makhoul, John Strouboulis, Giovanna Lombardi, Eugene Oteng-Ntim, Panicos Shangaris, Panicos Shangaris   +6 more
doaj   +1 more source

Vancomycin-induced gut microbiota dysbiosis aggravates allergic rhinitis in mice by altered short-chain fatty acids

Frontiers in Microbiology, 2022
ObjectiveThis study aims to explore how gut microbiota dysbiosis affects allergic rhinitis (AR) and whether short-chain fatty acids (SCFAs) play a role in this process.MethodsA mouse gut microbiota dysbiosis model was established by adding vancomycin to ...
Zhen Chen, Zhen Chen, Qingqing Xu, Qingqing Xu, Yang Liu, Yang Liu, Yihan Wei, Yihan Wei, Shancai He, Wei Lin, Wei Lin, Yingge Wang, Yingge Wang, Li Li, Yuanteng Xu, Yuanteng Xu   +15 more
doaj   +1 more source

Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?

Journal of Transplantation, 2012
The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic efforts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used
Francisco Salcido-Ochoa, Nurhashikin Yusof, Susan Swee-Shan Hue, Doreen Haase, Terence Kee, Olaf Rotzschke   +5 more
doaj   +1 more source

Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis

Frontiers in Pediatrics, 2022
BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang, Fei Hao, Tian Qian, Hai-xing Cheng   +3 more
doaj   +1 more source

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment [PDF]

, 2017
Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses.
Jassem, W., McGregor, R., Nova-Lamperti, E., Hayee, B.H., Grageda, N., Hoong, S.-J., Hannen, R.F., Lechler, R.I., Mckinney, O., Romano, M., Karagiannis, S.N., Powell, N., Correa, I., Yuksel, M., Pavlidis, P., Ong, M., Halim, L., Lombardi, G.   +17 more
core   +1 more source

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

OncoImmunology, 2017
Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells.
Daniele Maggioni, Lorenzo Pignataro, Werner Garavello   +2 more
doaj   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source