Results 21 to 30 of about 111,477 (307)

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

OncoImmunology, 2022
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood   +21 more
doaj   +1 more source

In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System

Frontiers in Cell and Developmental Biology, 2021
Sickle Cell Disease (SCD) is an autosomal recessive disorder resulting from a β-globin gene missense mutation and is among the most prevalent severe monogenic disorders worldwide.
Alba Saenz de Villaverde Cortabarria, Laura Makhoul, John Strouboulis, Giovanna Lombardi, Eugene Oteng-Ntim, Panicos Shangaris, Panicos Shangaris   +6 more
doaj   +1 more source

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs [PDF]

, 2020
Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy.
Nikkels, Peter G J, Scholman, R.C., Wienke, Judith, Judith Wienke, Bas B. van Rijn, Wienke, J., van Rijn, Bas B, Brouwers, L, Peter G.J. Nikkels, Mokry, M, Brouwers, L., van der Burg, Leone M, van der Burg, LM, van Wijk, F., Mokry, Michal, van der Burg, L.M., Rijn, B.B., Scholman, Rianne C, Nikkels, PGJ, Rianne C. Scholman, Leone M. van der Burg, Femke van Wijk, Scholman, RC, Michal Mokry, van Wijk, Femke, Wienke, J, Laura Brouwers, van Rijn, Bas, Brouwers, Laura, van Wijk, F   +29 more
core   +1 more source

Tregs and allergic disease [PDF]

Journal of Clinical Investigation, 2004
Allergic diseases such as asthma, rhinitis, and eczema are increasing in prevalence and affect up to 15% of populations in Westernized countries. The description of Tregs as T cells that prevent development of autoimmune disease led to considerable interest in whether these Tregs were also normally involved in prevention of sensitization to allergens ...
Douglas S, Robinson, Mark, Larché, Stephen R, Durham   +2 more
openaire   +2 more sources

Vancomycin-induced gut microbiota dysbiosis aggravates allergic rhinitis in mice by altered short-chain fatty acids

Frontiers in Microbiology, 2022
ObjectiveThis study aims to explore how gut microbiota dysbiosis affects allergic rhinitis (AR) and whether short-chain fatty acids (SCFAs) play a role in this process.MethodsA mouse gut microbiota dysbiosis model was established by adding vancomycin to ...
Zhen Chen, Zhen Chen, Qingqing Xu, Qingqing Xu, Yang Liu, Yang Liu, Yihan Wei, Yihan Wei, Shancai He, Wei Lin, Wei Lin, Yingge Wang, Yingge Wang, Li Li, Yuanteng Xu, Yuanteng Xu   +15 more
doaj   +1 more source

Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?

Journal of Transplantation, 2012
The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic efforts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used
Francisco Salcido-Ochoa, Nurhashikin Yusof, Susan Swee-Shan Hue, Doreen Haase, Terence Kee, Olaf Rotzschke   +5 more
doaj   +1 more source

Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis

Frontiers in Pediatrics, 2022
BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang, Fei Hao, Tian Qian, Hai-xing Cheng   +3 more
doaj   +1 more source

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

OncoImmunology, 2017
Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells.
Daniele Maggioni, Lorenzo Pignataro, Werner Garavello   +2 more
doaj   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p

Frontiers in Immunology, 2022
BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders.
Na Li, Zhiqi Gao, Lu Zhao, Bei Du, Binyun Ma, Hong Nian, Ruihua Wei   +6 more
doaj   +1 more source