Results 21 to 30 of about 120,068 (304)

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs [PDF]

, 2020
Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy.
Nikkels, Peter G J, Scholman, R.C., Wienke, Judith, Judith Wienke, Bas B. van Rijn, Wienke, J., van Rijn, Bas B, Brouwers, L, Peter G.J. Nikkels, Mokry, M, Brouwers, L., van der Burg, Leone M, van der Burg, LM, van Wijk, F., Mokry, Michal, van der Burg, L.M., Rijn, B.B., Scholman, Rianne C, Nikkels, PGJ, Rianne C. Scholman, Leone M. van der Burg, Femke van Wijk, Scholman, RC, Michal Mokry, van Wijk, Femke, Wienke, J, Laura Brouwers, van Rijn, Bas, Brouwers, Laura, van Wijk, F   +29 more
core   +1 more source

Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?

Journal of Transplantation, 2012
The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic efforts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used
Francisco Salcido-Ochoa, Nurhashikin Yusof, Susan Swee-Shan Hue, Doreen Haase, Terence Kee, Olaf Rotzschke   +5 more
doaj   +1 more source

Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis

Frontiers in Pediatrics, 2022
BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang, Fei Hao, Tian Qian, Hai-xing Cheng   +3 more
doaj   +1 more source

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma

OncoImmunology, 2017
Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells.
Daniele Maggioni, Lorenzo Pignataro, Werner Garavello   +2 more
doaj   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

In vivo dynamical interactions between CD4 Tregs, CD8 Tregs and CD4+ CD25- cells in mice. [PDF]

, 2009
BACKGROUND: Regulatory T cells (Tregs) were shown to be central in maintaining immunological homeostasis and preventing the development of autoimmune diseases.
Avidan U Neumann, Heidy Zinger, Amir Sharabi, Edna Mozes, Avidan U. Neumann, Arnon Arazi   +5 more
core   +1 more source

MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p

Frontiers in Immunology, 2022
BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders.
Na Li, Zhiqi Gao, Lu Zhao, Bei Du, Binyun Ma, Hong Nian, Ruihua Wei   +6 more
doaj   +1 more source

MALAT1 Induces Food Allergy by Promoting Release of IL-6 from Dendritic Cells and Suppressing the Immunomodulatory Function of Tregs

Journal of Asthma and Allergy, 2022
Hua Feng,1,2 Xiujuan Xiong,3 Zhuo Chen,1 Nan Luo,2 Yongning Wu1,4,5 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330000, People’s Republic of China; 2School of Public Health, Nanchang University, Nanchang, 330006 ...
Feng H, Xiong X, Chen Z, Luo N, Wu Y
doaj  

Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer

Cancer Biology & Therapy, 2023
A comprehensive analysis of the molecular mechanism underlying colorectal tumor evaluated the development of colorectal cancer (CRC) and proposed targeting small molecular inhibitors.
Lili Huang, Yu Zhao, Mengying Shan, Sitong Wang, Jianhua Chen, Zhuqing Liu, Qing Xu   +6 more
doaj   +1 more source

Increased Plasticity of FOXP3+ Treg under Pathological Conditions Convert Treg into Either Novel Treg or Th1‐Treg

The FASEB Journal, 2018
Naïve CD4+ Th (T helper cells) can differentiate/be polarized in to 9 terminally differentiated Th cell subsets depending on the cytokine repertoire and anatomical location. CD4+ FOXP3+ (forkhead box P3) regulatory T cells (Treg) are one of the Th subsets.
Keman Xu, William Y. Yang, Gayani K. Nanayakkara, Ying Shao, Fan Yang, Wenhui Hu, Eric T. Choi, Hong Wang, Xiaofeng Yang   +8 more
openaire   +1 more source