Results 31 to 40 of about 124,395 (259)

MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p

Frontiers in Immunology, 2022
BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders.
Na Li, Zhiqi Gao, Lu Zhao, Bei Du, Binyun Ma, Hong Nian, Ruihua Wei   +6 more
doaj   +1 more source

MALAT1 Induces Food Allergy by Promoting Release of IL-6 from Dendritic Cells and Suppressing the Immunomodulatory Function of Tregs

Journal of Asthma and Allergy, 2022
Hua Feng,1,2 Xiujuan Xiong,3 Zhuo Chen,1 Nan Luo,2 Yongning Wu1,4,5 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330000, People’s Republic of China; 2School of Public Health, Nanchang University, Nanchang, 330006 ...
Feng H, Xiong X, Chen Z, Luo N, Wu Y
doaj  

Targeting crosstalk of STAT3 between tumor-associated M2 macrophages and Tregs in colorectal cancer

Cancer Biology & Therapy, 2023
A comprehensive analysis of the molecular mechanism underlying colorectal tumor evaluated the development of colorectal cancer (CRC) and proposed targeting small molecular inhibitors.
Lili Huang, Yu Zhao, Mengying Shan, Sitong Wang, Jianhua Chen, Zhuqing Liu, Qing Xu   +6 more
doaj   +1 more source

Gate strategy analysis of Tregs.

, 2022
Dot/contour plots are representative of the analysis strategy used. First the gate of lymphocytes (SSC-A x FSC-A) was delimited, and from it the gate for single cells (FSC-H x FSC-A) was made. From the resulted population CD3+ followed by CD4+, and CD25+
Marcela Helena Gonçalves-Pereira (12488285), Jacqueline I. Alvarez-Leite (12488294), Maria A. Gomes (5687384), Camila P. Queiroz-Glauss (12488279), Mariana S. Vieira (12488282), Rachel H. Freire (12488291), Stephanie S. Almeida (12488288), Helton C. Santiago (12488297)   +7 more
core   +1 more source

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs [PDF]

, 2020
Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy.
Nikkels, Peter G J, Scholman, R.C., Wienke, Judith, Judith Wienke, Bas B. van Rijn, Wienke, J., van Rijn, Bas B, Brouwers, L, Peter G.J. Nikkels, Mokry, M, Brouwers, L., van der Burg, Leone M, van der Burg, LM, van Wijk, F., Mokry, Michal, van der Burg, L.M., Rijn, B.B., Scholman, Rianne C, Nikkels, PGJ, Rianne C. Scholman, Leone M. van der Burg, Femke van Wijk, Scholman, RC, Michal Mokry, van Wijk, Femke, Wienke, J, Laura Brouwers, van Rijn, Bas, Brouwers, Laura, van Wijk, F, CTI Van Loosdregt, CTI Van Wijk, Child Health, Onderzoek Precision medicine, MS Verloskunde, Infection & Immunity, Pathologie Pathologen staf, Circulatory Health, Arts-assistenten DV&B, Cancer   +39 more
core   +1 more source

The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis

Virulence, 2020
Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation, Akram A. Da’Dara, Patrick J. Skelly   +2 more
doaj   +1 more source

RETRACTED: Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction

Frontiers in Immunology, 2023
BackgroundTregs plays a critical role in the development of secondary injuries in diseases. Accumulating evidence suggests an association between ischemic stroke and renal dysfunction; however, the underlying mechanisms remain unclear.
Shuai Wang, Yubin Shi, Yanqi Zhang, Fengyun Yuan, Mintao Mao, Jun Ma   +5 more
doaj   +1 more source

KO Tregs were hyperfunctional.

, 2014
CFSE-labeled Teffs were stimulated in the presence of DCs and Tregs from WT or KO mice. On the 3rd day, the cells were harvested and stained for surface CD4.
Anbok Lee (532405), Jeong-Hae Kie (532407), Woosung Lim (532408), Byung-In Moon (532410), Ju-Young Seoh (439510), Eun-Jeong Choi (389699), Hyung-Ran Kim (532404), Hyeon Kook Lee (532409)   +7 more
core   +1 more source

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4⁺ T Cells

Vaccines, 2019
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and it exhibits resistance to common breast cancer therapies. Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and its ligand, PD-L1, have been
Reem Saleh, Salman M Toor, Sarah Khalaf, Eyad Elkord   +3 more
doaj   +1 more source

Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients

OncoImmunology, 2020
The immune modulatory effect of tivozanib, a tyrosine kinase inhibitor, and the underlying immune mechanisms impacting survival of HCC patients have not been investigated.
Suresh Gopi Kalathil, Katy Wang, Alan Hutson, Renuka Iyer, Yasmin Thanavala   +4 more
doaj   +1 more source