Results 201 to 210 of about 93,800 (248)

Case Report: Extracorporeal photopheresis for cutaneous lupus erythematosus induces putatively atheroprotective B and T cell responses. [PDF]

Front Immunol
Visentini M, Ozsvar-Kozma M, Pacella I, Pinzon Grimaldos A, Falco F, Shafii-Bafti M, Minicocci I, La Gualana F, Carlesimo M, Casato M, Basili S, Arca M, Piconese S, Fiorilli M, Binder CJ.   +14 more
europepmc   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, EarlyView.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

Reduced TIGIT Expression on T Cells Links Hyperglycemia to Immune Dysregulation in Type 1 Diabetes. [PDF]

Cells
Tomaszewicz M, Ronowska A, Strzelecka J, Jankowska-Kulawy A, Stefańska K, Trzonkowski P, Zieliński M.   +6 more
europepmc   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

TRIP13 promotes the expansion and immunosuppression of CD4⁺Foxp3⁺ regulatory T cells by sustaining HAT1 stability. [PDF]

Cell Death Dis
He T, Zhao L, Feng CT, Zhao LY, Jing S, Yang H, Wang K, Ye S, Zhao Y, Yu Y, Fu Z, Chou CK, Chen X, Gao YJ.   +13 more
europepmc   +1 more source

Programmable Semi‐Interpenetrating Living Materials With Robust Stability for Versatile Bioremediation and Biotherapeutics

Advanced Science, EarlyView.
A semi‐interpenetrating engineered living material (sIHSELM), fabricated via thermosensitive hydroxybutyl chitosan and covalent protein self‐assembly, demonstrates exceptional mechanical properties and environmental stability. Shielding bacteria from harsh conditions, sIHSELM exhibits remarkable efficacy in ulcerative colitis treatment and pollutants ...
Zixian Bao, Shengfeng Yang, Dandan Hu, Jiezheng Liu, Bo Jiang, Xinyue Sui, Qingsheng Qi, Lai Li, Guang Zhao   +8 more
wiley   +1 more source

OX40 signaling in cancer immunotherapy: mechanisms of action, translational applications, and therapeutic perspectives. [PDF]

Front Immunol
Luo Y, Li J, Li L, Qin B, Zhou R, Tang Y.   +5 more
europepmc   +1 more source

High‐Sensitive Mass Cytometry Metal Tags Based on Noble Metal Nanoparticles Assisting Acute Myeloid Leukemia Immune Checkpoint Profiling

Advanced Science, EarlyView.
ABSTRACT Mass cytometry is optimal for acute leukemia immune checkpoint profiling. However, current commercial metal‐chelating polymer (MCP) metal tags limit its sensitivity due to low metal loading capacity. We report a novel synthetic strategy employing antibody‐conjugated gold or platinum nanoparticles (AuNP/PtNP) for high‐dimensional single‐cell ...
Zhizhou Liu, Yu Yang, Lingfei Qiu, Yi Yang, Jingrui Li, Juan Yue, Yinghui Li, Yingdai Gao, Pengli Bai   +8 more
wiley   +1 more source

Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development. [PDF]

Cell Rep
Xie X, Thornton AM, Tanwar S, Korty P, Wells AC, Segrist E, Teijeiro A, Rivera CA, Wei D, Chen X, Zhu J, Khleborodova A, Hill T, Markowitz TE, Smelkinson M, Kabat J, Veres T, Schwartz OM, Otaizo-Carrasquero F, Gardina P, Shamsaddini A, Martens C, Cho K, Lin CC, Khillan JS, Levin Y, Wu Y, Shevach EM.   +27 more
europepmc   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source