Results 41 to 50 of about 290 (115)

Discovery of diphenyl ethers as novel inhibitors of insect trehalase via virtual screening and biological assays

Advanced Agrochem
Trehalase hydrolyzes trehalose to glucose to provide energy for insects or building blocks for chitin synthesis. Because trehalase is critical to insects but not to humans, it has long been considered a promising target for green insecticides.
Xi Jiang, Wenda Li, Qiong Lu, Yi Ding, Mingjia Gao, Shanru He, Wei Liu, Yong Zhou, Tian Liu   +8 more
doaj   +1 more source

Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae

Brazilian Journal of Medical and Biological Research, 2002
Saccharomyces cerevisiae neutral trehalase (encoded by NTH1) is regulated by cAMP-dependent protein kinase (PKA) and by an endogenous modulator protein.
Souza A.C., De Mesquita J.F., Panek A.D., Silva J.T., Paschoalin V.M.F.   +4 more
doaj  

Long-term effects of the trehalase inhibitor trehazolin on trehalase activity in locust flight muscle [PDF]

Journal of Experimental Biology, 2010
SUMMARY Trehalase (EC 3.2.1.28) hydrolyzes the main haemolymph sugar of insects, trehalose, into the essential cellular substrate glucose. Trehalase in locust flight muscle is bound to membranes that appear in the microsomal fraction upon tissue fractionation, but the exact location in vivo has remained elusive.
Gerhard, Wegener, Claudia, Macho, Paul, Schlöder, Günter, Kamp, Osamu, Ando   +4 more
openaire   +2 more sources

Combined lactase and trehalase deficiency as a cause of blood lose in young man

Czech Journal of Food Sciences
Trehalose is a disaccharide composed of two glucose that can be found in various plant and animal species. Mammals are not able to synthesize trehalose but it is usually easily enzymatically broken down into 2 molecules of glucose.
Natalie Friedova, Diana Chrpova, Jana Tajtlova, Martina Kollerova, Pavel Kohout   +4 more
doaj   +1 more source

Trealose e trealase em tenebrio molitor L Trehalose and Trehalase in Tenebrio molitor L

Memorias do Instituto Oswaldo Cruz, 1972
Foi estudada a concentração em trealose e a atividade em trealase do Tenebrio molitor L. durante as tres fases da metamorfose (larva, ninfa, imago). Verificou-se que na larva e no adulto os valores são mais elevados conforme a curva da fig. 3. A trealose
Cristina Piedras Lopes, Gilberto Villela
doaj   +1 more source

Knockdown of Two Trehalase Genes by RNA Interference Is Lethal to the White-Backed Planthopper Sogatella furcifera (Horváth) (Hemiptera: Delphacidae)

Biomolecules, 2022
Trehalase (Tre) is a crucial enzyme involved in trehalose metabolism, and it plays pivotal roles in insect development and metamorphosis. However, the biological function of Tre genes in Sogatella furcifera remains unclear.
Zhao Wang, Gui-Yun Long, Dao-Chao Jin, Hong Yang, Cao Zhou, Xi-Bin Yang   +5 more
doaj   +1 more source

Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study

Insects, 2022
Trehalase inhibitors are considered safe alternatives for insecticides and fungicides. However, there are no studies testing these compounds on Anopheles gambiae, a major vector of human malaria.
Eunice O. Adedeji, Gbolahan O. Oduselu, Olubanke O. Ogunlana, Segun Fatumo, Rainer Koenig, Ezekiel Adebiyi   +5 more
doaj   +1 more source

Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors

Angewandte Chemie International Edition, 2007
Peer ...
Gibson, Robert P., Gloster, Tracey M., Roberts, Shirley, Warren, R. Anthony J., Storch, Isabel, García, Ángela, Chiara, José Luis, Davies, Gideon J.   +7 more
openaire   +3 more sources

The activity of saccharolytic enzymes in Collembola is associated with species affinity for caves

International Journal of Speleology, 2018
The activity of enzymes associated with digestion can reflect food availability and feeding preferences of invertebrates in a particular habitat. Caves are mostly nutrient-poor habitats lacking primary production.
Andrea Parimuchová, Vladimír Šustr, Miloslav Devetter, Ondřej Vošta, Ionuţ Popa, Ľubomír Kováč   +5 more
doaj   +1 more source

NEUROSPORA TREHALASE AND ITS STRUCTURAL GENE [PDF]

Genetics, 1985
ABSTRACT We have isolated Neurospora trehalaseless mutants and mapped the trehalase structural gene to linkage group I. The structural gene mutations not only affect thermostability and other characteristics of the enzyme but also affect the production of an inhibitor of the wild-type trehalase.
C, White, D B, Lee, S J, Free
openaire   +2 more sources