Characterization of Treponema pallidum Dissemination in C57BL/6 Mice
Frontiers in Immunology, 2021 The spirochetal pathogen Treponema pallidum causes 5 million new cases of venereal syphilis worldwide each year. One major obstacle to syphilis prevention and treatment is the lack of suitable experimental animal models to study its pathogenesis ...
Yimou Wu, Yafeng Xie, Wu Yimou
exaly +4 more sources
Treponema pallidum protein Tp0136 promotes angiogenesis to facilitate the dissemination of Treponema pallidum [PDF]
Emerging Microbes and InfectionsThe incompletely eliminated Treponema pallidum (T. pallidum) during primary syphilis chancre infection can result in the progression of secondary, tertiary, or latent syphilis in individuals, suggesting that T. pallidum has successfully evaded the immune
Xi Luo, Tian-Ci Yang, Xin-Qi Zheng
exaly +4 more sources
Treponema Pallidum: A Forgotten Pathogen With Major Cardiovascular Consequence. [PDF]
JACC Case RepThe incidence of syphilis has increased in the last 2 decades. This case describes a 43-year-old with aortic aneurysm and symptomatic aortic regurgitation initially suspected to be congenital and later confirmed as syphilitic in etiology, illustrating a ...
Natour SJ +5 more
europepmc +3 more sources
Genomic Analysis of Doxycycline Resistance–Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum [PDF]
Emerging Infectious DiseasesWe inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance.
George S. Long +13 more
doaj +2 more sources
Detection of Treponema pallidum tpp47 DNA in clinical samples of syphilis patients [PDF]
European Journal of Medical ResearchBackgrounds To investigate the relationship between the presence of Treponema pallidum DNA in saliva, serum, and cerebrospinal fluid (CSF) in patients with different stages of syphilis.
Yongjun Meng +5 more
doaj +2 more sources
NOTES ON THE CULTIVATION OF TREPONEMA PALLIDUM [PDF]
Journal of Experimental Medicine, 1915 We consider themost importantcontribution reported in this paper the fact that Treponema pallidum can be cultivated in fluid media, without the addition of agar, together with tissues sterilized by heat. This forms an excellent method of obtaining mass cultures for luetin preparation and immunological experimentation.
H Zinsser, Zinsser Hans
exaly +3 more sources
Genetic engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete.
PLoS Pathogens, 2021 Despite more than a century of research, genetic manipulation of Treponema pallidum subsp. pallidum (T. pallidum), the causative agent of syphilis, has not been successful.
Emily Romeis +5 more
doaj +2 more sources
Microbiology Spectrum, 2022 Treponema pallidum can invade any organ, and T. pallidum DNA can be detected in various tissues and fluids. However, the knowledge of the presence and loads of T. pallidum DNA in urine is limited.
Cuini Wang +7 more
doaj +2 more sources
Long-Term
mBio, 2018 Investigation of Treponema pallidum subsp. pallidum, the spirochete that causes syphilis, has been hindered by an inability to culture the organism continuously in vitro despite more than a century of effort.
Diane G. Edmondson +2 more
doaj +2 more sources
Loop-mediated isothermal amplification assays for the rapid discrimination of Treponema pallidum lineages and subspecies [PDF]
Microbiology SpectrumMolecular surveillance aimed at identifying the subspecies and lineages of Treponema pallidum is important. Conventional molecular methods for genotyping are effective but are also time-consuming and costly.
Kazuo Imai +9 more
doaj +2 more sources