Results 11 to 20 of about 22,162 (180)

Genomic Analysis of Doxycycline Resistance-Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum. [PDF]

Emerg Infect Dis
We inspected 16S rRNA sequences of 784 publicly available Treponema pallidum subspecies pallidum genomes and 17 new T. pallidum subsp. pallidum genomes from Canada for putative mutations associated with doxycycline resistance.
Long GS, Neale M, Braukmann T, Tran V, Singh N, Allen V, Morshed M, Minion J, Van Caeseele P, Vallée M, Hatchette T, Patel SN, Tsang RSW, Duvvuri VR.   +13 more
europepmc   +2 more sources

Diagnosis of Syphilis in Paraffin-Embedded Skin Biopsies: Comparison of <i>Treponema pallidum</i> Immunohistochemistry and Polymerase Chain Reaction in Primary and Secondary Stages of Disease. [PDF]

Dermatopathology (Basel)
Syphilis remains one of the most prevalent sexually transmitted infections. Serology is the diagnostic gold standard, but skin biopsies aid in ambiguous cases.
Fuchs CC, Stoffers B, Braun SA, Böer-Auer A.   +3 more
europepmc   +2 more sources

NOTES ON THE CULTIVATION OF TREPONEMA PALLIDUM [PDF]

Journal of Experimental Medicine, 1915
We consider themost importantcontribution reported in this paper the fact that Treponema pallidum can be cultivated in fluid media, without the addition of agar, together with tissues sterilized by heat. This forms an excellent method of obtaining mass cultures for luetin preparation and immunological experimentation.
H, Zinsser, J G, Hopkins, R, Gilbert
openaire   +4 more sources

Molecular characterization of Treponema pallidum-related rabbit-derived material following experimental inoculation with human chancre-derived clinical specimens: a pilot exploratory study. [PDF]

BMC Microbiol
Background Syphilis remains a major sexually transmitted infection worldwide. Treponema pallidum subspecies pallidum is difficult to investigate under conventional laboratory cultivation conditions, which limits experimental and molecular studies ...
Syrym N, Abdykalyk A, Kokanov S, Yespembetov B, Nakhanov A, Terebay A, Toleukhan A, Alpysbayeva S, Anarbekova A, Sarmykova M, Serikbay Y, Yerzhigit B, Tileukhanov K, Zhakypbek A, Abdimukhtar A.   +14 more
europepmc   +2 more sources

Treponema pallidum protein Tp0136 promotes angiogenesis to facilitate the dissemination of Treponema pallidum. [PDF]

Emerg Microbes Infect
The incompletely eliminated Treponema pallidum (T. pallidum) during primary syphilis chancre infection can result in the progression of secondary, tertiary, or latent syphilis in individuals, suggesting that T. pallidum has successfully evaded the immune
Li W, Luo X, Zheng XQ, Li QL, Li Z, Meng QQ, Zeng YL, Lin Y, Yang TC.   +8 more
europepmc   +2 more sources

Detection of Treponema pallidum tpp47 DNA in clinical samples of syphilis patients. [PDF]

Eur J Med Res
Backgrounds To investigate the relationship between the presence of Treponema pallidum DNA in saliva, serum, and cerebrospinal fluid (CSF) in patients with different stages of syphilis.
Meng Y, Yang L, Fu Y, Li S, Hamal K, Liu D.   +5 more
europepmc   +2 more sources

Treponema Pallidum: A Forgotten Pathogen With Major Cardiovascular Consequence. [PDF]

JACC Case Rep
The incidence of syphilis has increased in the last 2 decades. This case describes a 43-year-old with aortic aneurysm and symptomatic aortic regurgitation initially suspected to be congenital and later confirmed as syphilitic in etiology, illustrating a growing need to consider tertiary syphilis as a cause of aortopathy.
Natour SJ, Rabadia SV, Stefanko DP, Fishbein GA, Parikh RV, Hsu JJ.   +5 more
europepmc   +5 more sources

Loop-mediated isothermal amplification assays for the rapid discrimination of <i>Treponema pallidum</i> lineages and subspecies. [PDF]

Microbiol Spectr
Molecular surveillance aimed at identifying the subspecies and lineages of Treponema pallidum is important. Conventional molecular methods for genotyping are effective but are also time-consuming and costly.
Imai K, Ohama Y, Sato A, Tanaka M, Omachi R, Takeuchi K, Mizushina H, Nakayama S-i, Maeda T, Akeda Y.   +9 more
europepmc   +2 more sources

An Adenoviral-Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model. [PDF]

Adv Sci (Weinh)
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Jiang Y, Li X, Huang L, Zhang X, Ke W.
europepmc   +2 more sources

Research progress in syphilis immunity

Pifu-xingbing zhenliaoxue zazhi, 2022
Syphilis is a sexually transmitted disease caused by treponema pallidum infection. It is mainly transmitted through mucous membrane or injured skin.
Ruihua ZHANG, Qianqiu WANG
doaj   +1 more source