Results 31 to 40 of about 46,044 (219)

Seroprevalence with epidemiological determinants of hepatitis C virus and Treponema pallidum infection in blood donors of a teaching hospital in southwest Punjab, India: A 5-year study

Journal of Family Medicine and Primary Care, 2023
Background: A high seroprevalence of various transfusion-transmitted infections (TTIs) in donated blood is the main safety concern, especially in low- and middle-income countries.
Nidhi Bansal, Anshul Gupta, Tanvir K. Sidhu, Ram Niwas Maharishi, Saurabh Gupta, Arnav K. Roychoudhury   +5 more
doaj   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Treponema pallidum Tp0751 alters the expression of tight junction proteins by promoting bEnd3 cell apoptosis and IL-6 secretion.

International Journal of Medical Microbiology, 2022
BACKGROUND Neurosyphilis is a serious complication caused by the invasion of the central nervous system by Treponema pallidum subsp. pallidum (T. pallidum). However, the molecular mechanism by which T.
Simin Lu, Jianye Wang, Zhangping He, Siqin He, K. Zheng, Man Xu, S. Yuan, Yimou Wu   +7 more
semanticscholar   +1 more source

Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated. Case presentation A 62-year-old Japanese male showed edema,
Akiko Kaiga, Yuka Sato, Haruna Arakawa, Tatemitsu Rai, Akihiro Tojo   +4 more
doaj   +1 more source

Notes on syphilis vaccine development

Frontiers in Immunology, 2022
The quest for a syphilis vaccine to provide protection from infection or disease began not long after the isolation of the first Treponema pallidum subspecies pallidum (T. pallidum) strain in 1912.
Noah Kojima, Kelika A. Konda, Kelika A. Konda, Jeffrey D. Klausner   +3 more
doaj   +1 more source

Structural Modeling of the Treponema pallidum Outer Membrane Protein Repertoire: a Road Map for Deconvolution of Syphilis Pathogenesis and Development of a Syphilis Vaccine

Journal of Bacteriology, 2021
The unusual outer membrane (OM) of T. pallidum, the syphilis spirochete, is the ultrastructural basis for its well-recognized capacity for invasiveness, immune evasion, and persistence. In recent years, we have made considerable progress in identifying T.
Kelly L. Hawley, Jairo M. Montezuma-Rusca, K. Delgado, Navreet Singh, V. Uversky, M. Caimano, J. Radolf, A. Luthra   +7 more
semanticscholar   +1 more source

Syphilis and the host: multi-omic analysis of host cellular responses to Treponema pallidum provides novel insight into syphilis pathogenesis

Frontiers in Microbiology, 2023
IntroductionSyphilis is a chronic, multi-stage infection caused by the extracellular bacterium Treponema pallidum ssp. pallidum. Treponema pallidum widely disseminates through the vasculature, crosses endothelial, blood–brain and placental barriers, and ...
Sean Waugh, Akash Ranasinghe, Alloysius Gomez, Simon Houston, Karen V. Lithgow, Azad Eshghi, Jenna Fleetwood, Kate M. E. Conway, Lisa A. Reynolds, Caroline E. Cameron, Caroline E. Cameron   +10 more
doaj   +1 more source

In vitro Transformation and Selection of Treponema pallidum subsp. pallidum

Current Protocols, 2022
Although the isolation of Treponema pallidum subsp. pallidum (T. pallidum) from a syphilis patient dates to 1912, for the duration of the 20th century, this pathogen has remained an exceedingly difficult organism to study due to the lack of a system to ...
Amber Phan, E. Romeis, L. Tantalo, L. Giacani   +3 more
semanticscholar   +1 more source

Multiplex nested polymerase chain reaction for Treponema pallidum using blood is more sensitive than using serum

Universa Medicina, 2018
Background Syphilis is a multistage disease transmitted primarily through sexual intercourse. Nowadays, the polymerase chain reaction (PCR) test for Treponema pallidum has been widely used and is expected to overcome problems in diagnostic tests for ...
Ida Effendi, Yeva Rosana, Andi Yasmon, Wresti Indriatmi   +3 more
doaj   +1 more source

Investigation of syphilis immunology and Treponema pallidum subsp. pallidum biology to improve clinical management and design a broadly protective vaccine: study protocol

BMC Infectious Diseases, 2020
Background The syphilis epidemic continues to cause substantial morbidity and mortality worldwide, particularly in low- and middle-income countries, despite several recent disease control initiatives.
Ethan Osias, Phoebe Hung, Lorenzo Giacani, Chrysovalantis Stafylis, Kelika A. Konda, Silver K. Vargas, E. Michael Reyes-Díaz, W. Scott Comulada, David A. Haake, Austin M. Haynes, Carlos F. Caceres, Jeffrey D. Klausner   +11 more
doaj   +1 more source