Results 21 to 30 of about 46,044 (219)

Advanced specificity and sensitivity studies relative to a research use only transcription-mediated amplification-based assay for Treponema pallidum RNA detection [PDF]

Journal of Clinical Microbiology
Preliminary experimentation has suggested that a research-use-only real-time transcription-mediated amplification assay for Treponema pallidum (RUO T. pallidum TMA) yields instances of T.
Trinity Krueger, Grace Kadonsky, Elizabeth Thelen, Amanda Zapp, Josephine Moore, Ahmet Muslu, Allan Pillay, Irene A. Stafford, Erik Munson   +8 more
doaj   +2 more sources

Research progress in syphilis immunity

Pifu-xingbing zhenliaoxue zazhi, 2022
Syphilis is a sexually transmitted disease caused by treponema pallidum infection. It is mainly transmitted through mucous membrane or injured skin.
Ruihua ZHANG, Qianqiu WANG
doaj   +1 more source

A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum.

Journal of materials chemistry. B, 2023
Syphilis, caused by Treponema pallidum (T. pallidum), is associated with the oxidative stress due to its inflammation-like symptom, and detecting the reactive oxygen species (ROS) is crucial for monitoring the infectious process.
Weiqiang Lin, Jialin Huang, Shuang Guo, Meijiao Zhao, Xu Chen, Qiuping Shang, Ruoyuan Zhang, Guangfu Liao, Judun Zheng, Yuhui Liao   +9 more
semanticscholar   +1 more source

Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis

Nature Microbiology, 2021
Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. pallidum, has an estimated 6.3 million cases worldwide per annum.
M. Beale, M. Marks, M. Cole, Min-Kuang Lee, R. Pitt, Christopher Ruis, E. Balla, T. Crucitti, M. Ewens, C. Fernández-Naval, A. Grankvist, M. Guiver, C. Kenyon, Rafil Khairullin, R. Kularatne, M. Arando, B. Molini, A. Obukhov, E. Page, F. Petrovay, C. Rietmeijer, Dominic Rowley, S. Shokoples, E. Smit, E. Sweeney, G. Taiaroa, J. Vera, C. Wennerås, D. Whiley, D. Williamson, G. Hughes, P. Naidu, M. Unemo, M. Krajden, S. Lukehart, M. Morshed, H. Fifer, N. Thomson   +37 more
semanticscholar   +1 more source

A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples

Nature Communications, 2022
The performance of commonly used assays for diagnosis of syphilis varies considerably depending on stage of infection and sample type. In response to the need for improved syphilis diagnostics, we develop assays that pair PCR pre-amplification of the ...
Wentao Chen, Hao Luo, Lihong Zeng, Yuying Pan, J. Parr, Yinbo Jiang, C. Cunningham, Kelly L. Hawley, J. Radolf, Wujian Ke, J. Ou, Jianjiang Yang, Bin Yang, Heping Zheng   +13 more
semanticscholar   +1 more source

Characterisation of Treponema pallidum lineages within the contemporary syphilis outbreak in Australia: a genomic epidemiological analysis.

The Lancet Microbe, 2022
BACKGROUND The incidence of syphilis has increased markedly in the past decade in high-income countries, including Australia. To date, however, genomic studies of Treponema pallidum have focused mainly on the northern hemisphere.
Mona L. Taouk, G. Taiaroa, S. Pasricha, Sophie Herman, E. Chow, Francesca Azzatto, Bowen Zhang, Cheryll M. Sia, S. Duchêne, Alvin J. X. Lee, N. Higgins, J. Prestedge, Y. Lee, N. Thomson, Bianca Graves, E. Meumann, M. Gunathilake, J. Hocking, C. Bradshaw, M. Beale, B. Howden, Marcus Y. Chen, C. Fairley, D. Ingle, D. Williamson   +24 more
semanticscholar   +1 more source

Phylogeny and antibiotic resistance of Treponema pallidum subsp. pallidum [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2023
The species Treponema pallidum includes 4 subspecies. According to the bioinformatic analysis, the syphilis pathogen T. pallidum subsp. pallidum was probably separated from the causative agents of yaws, bejel, and pinta more than 800 years ago. Its entry
Nosov N.Yu., Obraztsova O.A., Katunin G.L., Plakhova K.I., Solomka V.S.   +4 more
doaj   +1 more source

Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

PLoS Neglected Tropical Diseases, 2021
In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency ...
N. Lieberman, Michelle J. Lin, Hong Xie, Lasata Shrestha, Tien V. Nguyen, Meei-Li W Huang, Austin M Haynes, E. Romeis, Qianqiu Wang, Rui-Li Zhang, Cai-Xia Kou, G. Ciccarese, I. Dal Conte, M. Cusini, F. Drago, S. Nakayama, Ken-ichi Lee, M. Ohnishi, K. Konda, S. Vargas, Maria Eguiluz, C. Caceres, J. Klausner, O. Mitjà, A. Rompalo, F. Mulcahy, E. Hook, S. Lukehart, A. Casto, Pavitra Roychoudhury, F. DiMaio, L. Giacani, A. Greninger   +32 more
semanticscholar   +1 more source

In Vitro Cultivation of the Syphilis Spirochete Treponema pallidum

Current Protocols, 2021
For over a century, investigation of Treponema pallidum subsp. pallidum, the spiral‐shaped bacterium that causes syphilis, was hindered by an inability to culture the organism in vitro. A recent breakthrough has enabled continuous in vitro growth of this
D. Edmondson, S. Norris
semanticscholar   +1 more source

The prevalence and associated factors of among HIV-positive and HIV-negative individuals who attended voluntary counseling and testing center of St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia: A cross-sectional study design

SAGE Open Medicine, 2020
Background: Treponema pallidum and HIV are among the most common public health problems in Ethiopia. These infections are interrelated. Treponema pallidum causes genital ulcer which enhances HIV transmission and complicates HIV by causing severe ulcer ...
Habtamu Weldesenbet, Daniel Asrat, Yimtubezinash Weldeamanuel   +2 more
doaj   +1 more source