Results 1 to 10 of about 915 (119)

Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates [PDF]

Scientific Reports, 2019
In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species.
Idrissa S. Chuma, Christian Roos, Anagaw Atickem, Torsten Bohm, D. Anthony Collins, Linda Grillová, Luisa K. Hallmaier-Wacker, Rudovick R. Kazwala, Julius D. Keyyu, Simone Lüert, Ulrich Maloueki, Jan Oppelt, Klára J. Petrželková, Alexander Piel, Fiona A. Stewart, David Šmajs, Sascha Knauf   +16 more
doaj   +9 more sources

Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue. [PDF]

Emerg Microbes Infect, 2018
Dear Editor, The bacterium Treponema pallidum (TP) causes human syphilis (subsp. pallidum; TPA), bejel (subsp. endemicum; TEN), and yaws (subsp. pertenue; TPE) (1).
Knauf S, Gogarten JF, Schuenemann VJ, De Nys HM, Düx A, Strouhal M, Mikalová L, Bos KI, Armstrong R, Batamuzi EK, Chuma IS, Davoust B, Diatta G, Fyumagwa RD, Kazwala RR, Keyyu JD, Lejora IAV, Levasseur A, Liu H, Mayhew MA, Mediannikov O, Raoult D, Wittig RM, Roos C, Leendertz FH, Šmajs D, Nieselt K, Krause J, Calvignac-Spencer S.   +28 more
europepmc   +21 more sources

Geographically structured genomic diversity of non-human primate-infecting Treponema pallidum subsp. pertenue. [PDF]

Microb Genom, 2020
Many non-human primate species in sub-Saharan Africa are infected with Treponema pallidum subsp. pertenue
Mubemba B, Gogarten JF, Schuenemann VJ, Düx A, Lang A, Nowak K, Pléh K, Reiter E, Ulrich M, Agbor A, Brazzola G, Deschner T, Dieguez P, Granjon AC, Jones S, Junker J, Wessling E, Arandjelovic M, Kuehl H, Wittig RM, Leendertz FH, Calvignac-Spencer S.   +21 more
europepmc   +6 more sources

The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct. [PDF]

PLoS Neglected Tropical Diseases, 2023
BackgroundTreponema pallidum subsp. pertenue (TPE) is the causative agent of human yaws. Yaws is currently reported in 13 endemic countries in Africa, southern Asia, and the Pacific region.
Klára Janečková, Christian Roos, Pavla Fedrová, Nikola Tom, Darina Čejková, Simone Lueert, Julius D Keyyu, Idrissa S Chuma, Sascha Knauf, David Šmajs   +9 more
doaj   +7 more sources

Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea. [PDF]

PLoS Neglected Tropical Diseases, 2017
BackgroundYaws is a neglected tropical disease, caused by Treponema pallidum subsp. pertenue. The disease causes chronic lesions, primarily in young children living in remote villages in tropical climates.
Charmie Godornes, Lorenzo Giacani, Alyssa E Barry, Oriol Mitja, Sheila A Lukehart   +4 more
doaj   +6 more sources

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Indonesia: Modular structure of several treponemal genes. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Treponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multistage disease endemic in tropical regions in Africa, Asia, Oceania, and South America.
Michal Strouhal, Lenka Mikalová, Jan Haviernik, Sascha Knauf, Sylvia Bruisten, Gerda T Noordhoek, Jan Oppelt, Darina Čejková, David Šmajs   +8 more
doaj   +7 more sources

Topical treatment with gallium maltolate reduces Treponema pallidum subsp. pertenue burden in primary experimental lesions in a rabbit model of yaws. [PDF]

PLoS Neglected Tropical Diseases, 2019
BackgroundGallium is a semi-metallic element known since the 1930s to have antimicrobial activity. This activity stems primarily from gallium's ability to mimic trivalent iron and disrupt specific Fe(III)-dependent pathways, particularly DNA synthesis ...
Lorenzo Giacani, Lawrence R Bernstein, Austin M Haynes, B Charmie Godornes, Giulia Ciccarese, Francesco Drago, Aurora Parodi, Sefora Valdevit, Luca Anselmi, Carlo Francesco Tomasini, Arthur M Baca   +10 more
doaj   +6 more sources

Complete genome sequences of two strains of Treponema pallidum subsp. pertenue from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart. [PDF]

PLoS Neglected Tropical Diseases, 2017
BackgroundTreponema pallidum subsp. pertenue (TPE) is the causative agent of yaws, a multi-stage disease, endemic in tropical regions of Africa, Asia, Oceania, and South America.
Michal Strouhal, Lenka Mikalová, Pavla Havlíčková, Paolo Tenti, Darina Čejková, Ivan Rychlík, Sylvia Bruisten, David Šmajs   +7 more
doaj   +4 more sources

A Loop-Mediated Isothermal Amplification Assay for the Detection of Treponema pallidum subsp. pertenue. [PDF]

Am J Trop Med Hyg, 2020
The eradication of yaws caused by Treponema pallidum subsp. pertenue is constrained by the lack of rapid, accurate diagnosis. We sought to develop a molecular point-of-care test for the diagnosis of yaws. A loop-mediated isothermal amplification (LAMP) assay with primers targeting the conserved gene, tp0967, with visual detection by lateral flow test ...
Basing LAW, Simpson SV, Adu-Sarkodie Y, Linnes JC.   +3 more
europepmc   +4 more sources

Yaws Disease Caused by Treponema pallidum subspecies pertenue in Wild Chimpanzee, Guinea, 2019 [PDF]

Emerging Infectious Diseases, 2020
Yaws-like lesions are widely reported in wild African great apes, yet the causative agent has not been confirmed in affected animals. We describe yaws-like lesions in a wild chimpanzee in Guinea for which we demonstrate infection with Treponema pallidum ...
Benjamin Mubemba, Emeline Chanove, Kerstin Mätz-Rensing, Jan F. Gogarten, Ariane Düx, Kevin Merkel, Caroline Röthemeier, Andreas Sachse, Helene Rase, Tatyana Humle, Guillaume Banville, Marine Tchoubar, Sébastien Calvignac-Spencer, Christelle Colin, Fabian H. Leendertz   +14 more
doaj   +4 more sources