Results 141 to 150 of about 4,397 (170)
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TRF1 promotes parallel pairing of telomeric tracts in vitro
Journal of Molecular Biology, 1998Human telomeres consist of long arrays of TTAGGG repeats bound to the telomere-specific proteins, TRF1 and TRF2. Here we describe the structure of in vitro complexes formed between telomeric DNA and TRF1 as deduced by electron microscopy. Visualization of TRF1 bound to DNA containing six or 12 tandem TTAGGG repeats revealed a population of DNAs ...
Jack Griffith +2 more
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Telomere shortening and expression of TRF1 and TRF2 in uterine leiomyoma
Molecular Medicine Reports, 2021Uterine leiomyoma is a benign smooth muscle tumor of the uterus that can exhibit histopathological traits that mimic malignancy. Telomere shortening is an early event in tumorigenesis and telomerase activation facilitates tumor progression later in the course of carcinogenesis.
Bong-Kyeong, Oh +2 more
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Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle [PDF]
FEBS Letters, 2002 Pin2/TRF1 was independently identified as a telomeric DNA‐binding protein (TRF1) that regulates telomere length, and as a protein (Pin2) that can bind the mitotic kinase NIMA and suppress its lethal phenotype. We have previously demonstrated that Pin2/TRF1 levels are cell cycle‐regulated and its overexpression induces mitotic arrest and then apoptosis.
Masafumi Nakamura +2 more
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TRF1 binds a bipartite telomeric site with extreme spatial flexibility [PDF]
EMBO Journal, 1999 TRF1 is a key player in telomere length regulation. Because length control was proposed to depend on the architecture of telomeres, we studied how TRF1 binds telomeric TTAGGG repeat DNA and alters its conformation. Although the single Myb-type helix-turn-helix motif of a TRF1 monomer can interact with telomeric DNA, TRF1 predominantly binds as a ...
Arnaud Bianchi +2 more
exaly +3 more sources
Promoter-Selective Properties of the TBP-Related Factor TRF1
Science, 2000The TATA-binding protein (TBP)–related factor 1 (TRF1) is expressed in a tissue-restricted fashion during Drosophila embryogenesis and may serve as a promoter-specific recognition factor that can replace TBP in regulating transcription.
M C, Holmes, R, Tjian
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POT1 as a terminal transducer of TRF1 telomere length control
Nature, 2003Human telomere maintenance is essential for the protection of chromosome ends, and changes in telomere length have been implicated in ageing and cancer. Human telomere length is regulated by the TTAGGG-repeat-binding protein TRF1 and its interacting partners tankyrase 1, TIN2 and PINX1 (refs 5-9).
Diego, Loayza, Titia, De Lange
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Control of telomere length by the human telomeric protein TRF1
Nature, 1997Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific proteins. In normal human cells, telomeres shorten with successive cell divisions, probably due to the terminal sequence loss that accompanies DNA replication.
B, van Steensel, T, de Lange
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
2022A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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Identification of alternative transcripts of the TRF1/Pin2 gene
Journal of Cellular Biochemistry, 2004AbstractTRF1 and Pin2 play an essential role in telomere homeostasis, by regulating telomere maintenance. They are generated from the same gene, TRF1/Pin2, by alternative splicing but no functional differences between these proteins have been demonstrated.
Céline Silva, Lages +6 more
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Platination of telomeric DNA by cisplatin disrupts recognition by TRF2 and TRF1
JBIC Journal of Biological Inorganic Chemistry, 2010Telomeres, the nucleoprotein complexes located at the ends of chromosomes, are involved in chromosome protection and genome stability. Telomeric repeat binding factor 1 (TRF1) and telomeric repeat binding factor 2 (TRF2) are the two telomeric proteins that bind to duplex telomeric DNA through interactions between their C-terminal domain and several ...
Ourliac-Garnier, Isabelle +8 more
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