Results 151 to 160 of about 4,397 (170)
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TRF1 Inhibits Telomere C-Strand DNA Synthesis in Vitro
Biochemistry, 2001Human TTAGGG repeat-binding factor 1 (TRF1) is involved in the regulation of telomere length in vivo, but the mechanism of regulation remains largely undefined. We have developed an in vitro system for assessing the effect of TRF1 on DNA synthesis using purified proteins and synthetic DNA substrates.
E J, Smucker, J J, Turchi
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Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance
Mechanisms of Ageing and Development, 2012Telomeres, heterochromatic structures, found at the ends of linear eukaryotic chromosomes, function to protect natural chromosome ends from nucleolytic attack. Human telomeric DNA is bound by a telomere-specific six-subunit protein complex, termed shelterin/telosome.
John R, Walker, Xu-Dong, Zhu
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Immunohistochemical TRF1 expression in human primary intracranial tumors.
Anticancer research, 2001The telomeric-repeat binding factor (TRF1) participates in a physiological homeostatic mechanism controlling telomere shortening by inhibiting telomerase activity: down-regulation of TRF1 expression results in telomere elongation and may be involved in cell immortalization.To determine the TRF1 expression by immunohistochemistry (IHC) in human brain ...
ARAGONA M +8 more
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Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
Molecular Cell, 2017Rong Tan, Jian Wu, Sabine Hellwig
exaly
PML3 interacts with TRF1 and is essential for ALT-associated PML bodies assembly in U2OS cells
Cancer Letters, 2010Jianping Lan, Quan Wu
exaly
The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis
Biochemical and Biophysical Research Communications, 2014Jeonghee Kim, In Kwon Chung
exaly